Rinse & rePeat
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- Mar 10, 2021
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I have been reading about Clostridium Difficile because my husband has been diagnosed with it today. It is a "super bug" bacterial infection with a high mortality rate. The doctor said he got it from his last hospital visit for a spinal compression fracture. This is some scary stuff, but it is also suggested that it is under reported in Covid patients deaths. This is such a shocker to me in more ways than one!
"The dearth of studies regarding secondary infections, such as Clostridioides difficile, in COVID-19 patients makes it difficult to measure the effect of the pandemic on antimicrobial stewardship programs and on long term antimicrobial resistance. While increased awareness regarding personal hygiene and extensive use of protective equipment may lead to reductions of healthcare associated infections, the challenge of strictly isolating and managing COVID-19 patients in many healthcare systems, often in proximity to patients colonized with C. difficile, and the inevitable higher workload imposed on healthcare staff could lead to additional hospital transmissions. The increased use of antibiotics to treat COVID-19 may, inadvertently, have resulted in an under-reporting of C. difficile infection. Actually, Spigaglia (2020) has published an article expressing her opinion about the COVID-19 and the impact in elderly patients, who will probably become more susceptible to CDI. The author also demonstrates her concern about the low number of bacterial infections cases related to patients with Sars-Cov-2. To ensure appropriate treatment and to improve patient outcome, increased vigilance and improved diagnosis are both necessary. Given that future emerging viral diseases are highly likely, we would urge increased awareness of the issue and call for informed debate around how to implement effective measures to meet these challenges.
In conclusion, it seems highly likely that cases of CDI are being under-reported among COVID-19 patients and the increased use of antibiotics may, in part, be responsible."
"The COVID-19 pandemic has changed the way we practice medicine and lead our lives. In addition to pulmonary symptoms; COVID-19 as a syndrome has multisystemic involvement including frequent gastrointestinal symptoms such as diarrhea. Due to microbiome alterations with COVID-19 and frequent antibiotic exposure, COVID-19 can be complicated by Clostridioides difficile infection. Co-infection with these two can be associated with a high risk of complications."
"Clostridium difficile infection (CDI) has emerged as a major health care–associated infection; incidence, hospitalizations, and mortality rates are increasing (1,2). Reported case-fatality rates are 6%–30% and seem to be rising."
"The dearth of studies regarding secondary infections, such as Clostridioides difficile, in COVID-19 patients makes it difficult to measure the effect of the pandemic on antimicrobial stewardship programs and on long term antimicrobial resistance. While increased awareness regarding personal hygiene and extensive use of protective equipment may lead to reductions of healthcare associated infections, the challenge of strictly isolating and managing COVID-19 patients in many healthcare systems, often in proximity to patients colonized with C. difficile, and the inevitable higher workload imposed on healthcare staff could lead to additional hospital transmissions. The increased use of antibiotics to treat COVID-19 may, inadvertently, have resulted in an under-reporting of C. difficile infection. Actually, Spigaglia (2020) has published an article expressing her opinion about the COVID-19 and the impact in elderly patients, who will probably become more susceptible to CDI. The author also demonstrates her concern about the low number of bacterial infections cases related to patients with Sars-Cov-2. To ensure appropriate treatment and to improve patient outcome, increased vigilance and improved diagnosis are both necessary. Given that future emerging viral diseases are highly likely, we would urge increased awareness of the issue and call for informed debate around how to implement effective measures to meet these challenges.
In conclusion, it seems highly likely that cases of CDI are being under-reported among COVID-19 patients and the increased use of antibiotics may, in part, be responsible."
"The COVID-19 pandemic has changed the way we practice medicine and lead our lives. In addition to pulmonary symptoms; COVID-19 as a syndrome has multisystemic involvement including frequent gastrointestinal symptoms such as diarrhea. Due to microbiome alterations with COVID-19 and frequent antibiotic exposure, COVID-19 can be complicated by Clostridioides difficile infection. Co-infection with these two can be associated with a high risk of complications."
"Clostridium difficile infection (CDI) has emerged as a major health care–associated infection; incidence, hospitalizations, and mortality rates are increasing (1,2). Reported case-fatality rates are 6%–30% and seem to be rising."
Determining Mortality Rates Attributable to Clostridium difficile Infection
To determine accuracy of measures of deaths attributable to Clostridium difficile infection, we compared 3 measures for 2007–2008 in Ontario, Canada: death certificate; death within 30 days of infection; and panel review. Data on death within ...
www.ncbi.nlm.nih.gov
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