Is This Article On Bioidentical Hormones, Progesterone Dominance, Accurate?

[TreasureVibe]

Bioidentical Hormones
There has been a lot of talk about bio-identical hormones lately. They are being promoted as a "natural" alternative to pharmaceutical hormones. Bio-identical hormones are not natural though. They are synthesized in a lab, from plant sterols, just like many pharmaceutical hormones.

The term bio-identical is rather misleading. This implies that they are identical in every way to natural hormones. Though, this may not be the case. More than one substance can share the same atoms, and the same number of atoms yet still not be the same. Location of the atoms, and bond angles can make a substance different. For example glucose, galactose, and fructose are all C6H12O6, yet they are all different sugars. Hormones are no different. When synthesizing a compound I don't see any way to prove that all atoms are in the same exact position, nor that all bond angles are exactly the same. This is like the claims that natural and synthetic vitamin Es are identical. If this were the case though, then why are natural vitamin Es considerably stronger than their synthetic counterparts? There is obviously some differences. Since they have identical types and number of atoms, the only difference that could explain the difference in activity would be different bond angles between these two substances that are supposed to be identical.

There is a false belief that bio-identical hormones are safe. Ever hear of problems like progesterone dominance? I find it interesting that people promoting progesterone creams never bring up this problem. Could it be because it would hurt their sales or investments? Especially considering that the side effects of progesterone dominance are almost identical to the side effects of estrogen dominance. This has always made me wonder how many women are increasing their use of progesterone creams trying to treat what they feel is estrogen dominance, when in fact they are actually suffering from progesterone dominance.

Another fact that the sales people and sites fail to mention is that these hormones store in the body. They are not flushed within a short period of time as they claim. The majority of the hormones absorbed through the skin do not go directly in to the bloodstream. Instead the hormones store in the fat cells of the body and gradually increase in levels as the hormones accumulate. Many women that have been on progesterone creams for a while often have years worth of progesterone stored up in their fat cells. Keep in mind that this can also lead to atrophy of the glands that produce the hormones causing a dependence on the external source of hormones.

Source: Alt/Trad Medical Review

 

[lollipop]

I think there is some truth to the dominance idea. This is why Ray suggests cycling on and off. After I switched my estrogen dominance, I went off progesterone for several months and started back with low dose two weeks on and two weeks off like Ray usually recommends. Working very well!

 

[smith]

Many women that have been on progesterone creams for a while often have years worth of progesterone stored up in their fat cells. Keep in mind that this can also lead to atrophy of the glands that produce the hormones causing a dependence on the external source of hormones

What's the point of taking anything if it's just going to down-regulate your own endogenous production of it? Hence the importance of cycling, but what exactly ARE the exact amounts of time of an optimal cycle of whatever we take like progesterone/thyroid/blah?

 

[Jackrabbit]

I have found that the bio identical progesterone taken at night orally (swallowed not rubbed in gums) is the most effective and is the only way to take it that actually makes me feel calm and sleep really well. For me there’s no possible way to rub enough into the gums but I never actually felt anything from applying it that way anyway. Once I took too much progesterone and felt weird, like slightly drunk. Fortunately it was when I was going to sleep so it wasn’t an issue. Now I know how much I can take without getting to that point. Of course I never felt anything from progesterone until I started taking pre-ssri doses of Zoloft to reduce the conversion of allopregnanalone to inactive metabolites.