Is There A Peaty Alternative To Sulforaphane?

[AretnaP]

Like is there a way to get the mental effects of sulforaphane in a peaty manner because I head it can lower DHT.

Or is sulforaphane itself ok?

@haidut

 

[thomas00]

Sulphoraphane is a natural pesticide. It's not good.

Health benefits and possible risks of broccoli - an overview. - PubMed - NCBI
Cruciferous plants: phytochemical toxicity versus cancer chemoprotection. - PubMed - NCBI
Anti-angiogenic effects of dietary isothiocyanates: mechanisms of action and implications for human health. - PubMed - NCBI

 

[AretnaP]

Sulphoraphane is a natural pesticide. It's not good.

Health benefits and possible risks of broccoli - an overview. - PubMed - NCBI
Cruciferous plants: phytochemical toxicity versus cancer chemoprotection. - PubMed - NCBI
Anti-angiogenic effects of dietary isothiocyanates: mechanisms of action and implications for human health. - PubMed - NCBI

Is there anything that has it's mental benefits without being it?

 

[thomas00]

Not sure which mental benefits you are referring to there

 

[AretnaP]

Not sure which mental benefits you are referring to there

decreased anxiety and mental fatigue
increased focus
increased energy

 

[thomas00]

There are a lot of agents with those kind of benefits. A good diet can make a big difference.

If you want supplemental and pharmacuetical options then snoop around those sections of the forums. Cyproheptadine, aspirin, niacinamide, tianeptine, vitamin A and various steroid hormones are popular here, to name a few.

It all depends on your circumstances of course and what you are trying to address.

 

[Lurker]

Rhonda Patrick was hyping this stuff up pretty good on the Joe Rogan podcast. She has some blogs/vids that go into the positive benefits. Even advocating sprouting your own broccoli seeds and said the supplements were crap. I haven't dug into mechanisms to see if there were any downsides but I'm always skeptical when someone talks about some new esoteric compound is the secret to good health. At least she is for the natural food source and not just pushing pills. I doubt a few broccoli sprouts are going to push your health hard one way or the other so you could try it and see what it does for you. She is also a strict low carber so take it for what it's worth.

 

[johnwester130]

taurine

b vitamins

taurine is actually a sulfur bearing amino acid

"Some of the most common dietary forms of sulfur include methionine, methylsulfonylmethane (MSM), L-taurine, sulforaphane, N-acetyl-L-cysteine, thiamine (Vitamin B1), and biotin.1,2"

 

[Nikki]

Sulphoraphane is a natural pesticide. It's not good.

Health benefits and possible risks of broccoli - an overview. - PubMed - NCBI
Cruciferous plants: phytochemical toxicity versus cancer chemoprotection. - PubMed - NCBI
Anti-angiogenic effects of dietary isothiocyanates: mechanisms of action and implications for human health. - PubMed - NCBI

How do we know for certain it's risk outweigh the benefits? We are not insects.

 

[Tarmander]

I have been looking into this stuff lately. Gbold over at hack stasis has added it to his repertoire of cures/help for PFS. The amount of positive reviews on this stuff goes from hair loss to autism should warrant another look.

I am interested in things that help with autism, as I think some degree of it is suffered by millions of people.

 

[thomas00]

"However, recent in vitro and experimental animal studies indicate that broccoli, its extracts and the glucosinolate-derived degradation products might also have undesirable effects, especially genotoxic activities."
Health benefits and possible risks of broccoli - an overview. - PubMed - NCBI

Vegetable hatred is justified.

 

[Tarmander]

"However, recent in vitro and experimental animal studies indicate that broccoli, its extracts and the glucosinolate-derived degradation products might also have undesirable effects, especially genotoxic activities."
Health benefits and possible risks of broccoli - an overview. - PubMed - NCBI

Vegetable hatred is justified.

I dunno about hatred...

I am reading this study on sci hub.

This is the interesting part for in vivo:

In the 2006 study with those pigs, they found DNA breaks increased 21% for the raw broccoli, but blanched and then frozen showed no effects:

Here are some positive Human reviews, again cooking/blanching/freezing was necessary:

"Application of the Ames test revealed that broccoli processed in different ways (fresh juice, ethanolic or water extracts or blanched and frozen broccoli) exerted antigenotoxic effects against promutagens, carcinogens and direct alkylating agents in this test assay."

There is more to the study, and not all is positive, but it seems to make a strong case for staying away from Raw broccoli. What did you glean from it?

 

[thomas00]

I concluded the same

Steaming and boiling broccoli reduces glucosinolate, which results in reduced sulphoraphane.

If there aren't any other poisons in broccoli which are neutralized the same way then I guess that study is making a case for low-sulphorane broccoli being less toxic

 

[TreasureVibe]

Bump!

Phase 2 enzyme inducer sulphoraphane blocks prostaglandin and nitric oxide synthesis in human articular chondrocytes and inhibits cartilage matrix de... - PubMed - NCBI
Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1

 

[agnostic]

I am interested in things that help with autism, as I think some degree of it is suffered by millions of people.

I've been reading a lot about sulforaphane and autism lately and came to the conclusion that this is probably one of the most promising treatment strategies.
In 2014, there was this randomized controlled study

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15550-5. doi: 10.1073/pnas.1416940111. Epub 2014 Oct 13.
Sulforaphane treatment of autism spectrum disorder (ASD).
Singh K1, Connors SL2, Macklin EA3, Smith KD4, Fahey JW5, Talalay P6, Zimmerman AW7.
Author information

Abstract
Autism spectrum disorder (ASD), characterized by both impaired communication and social interaction, and by stereotypic behavior, affects about 1 in 68, predominantly males. The medico-economic burdens of ASD are enormous, and no recognized treatment targets the core features of ASD. In a placebo-controlled, double-blind, randomized trial, young men (aged 13-27) with moderate to severe ASD received the phytochemical sulforaphane (n = 29)--derived from broccoli sprout extracts--or indistinguishable placebo (n = 15). The effects on behavior of daily oral doses of sulforaphane (50-150 µmol) for 18 wk, followed by 4 wk without treatment, were quantified by three widely accepted behavioral measures completed by parents/caregivers and physicians: the Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and Clinical Global Impression Improvement Scale (CGI-I). Initial scores for ABC and SRS were closely matched for participants assigned to placebo and sulforaphane. After 18 wk, participants receiving placebo experienced minimal change (<3.3%), whereas those receiving sulforaphane showed substantial declines (improvement of behavior): 34% for ABC (P < 0.001, comparing treatments) and 17% for SRS scores (P = 0.017). On CGI-I, a significantly greater number of participants receiving sulforaphane had improvement in social interaction, abnormal behavior, and verbal communication (P = 0.015-0.007). Upon discontinuation of sulforaphane, total scores on all scales rose toward pretreatment levels. Dietary sulforaphane, of recognized low toxicity, was selected for its capacity to reverse abnormalities that have been associated with ASD, including oxidative stress and lower antioxidant capacity, depressed glutathione synthesis, reduced mitochondrial function and oxidative phosphorylation, increased lipid peroxidation, and neuroinflammmation.

Later, a follow up study was conducted on the same subjects:

Glob Adv Health Med. 2017 Oct 26;6:2164957X17735826. doi: 10.1177/2164957X17735826. eCollection 2017.
Sulforaphane from Broccoli Reduces Symptoms of Autism: A Follow-up Case Series from a Randomized Double-blind Study.
Lynch R1, Diggins EL1, Connors SL1, Zimmerman AW1,2,3,4,5, Singh K1, Liu H6,7, Talalay P6,7, Fahey JW6,7,8,9.
Author information

Abstract
INTRODUCTION:
Autism spectrum disorder (ASD) affects 1 in 68 children, is characterized by impaired social interaction and communication as well as restricted or repetitive behaviors, and varies widely with respect to its causes and presentations. There are no validated pharmacologic treatments for the core symptoms of ASD. The social, medical, and economic burdens of ASD on families and caregivers are profound. We recently showed in a small clinical trial that sulforaphane (SF) from broccoli sprouts could significantly reduce the behavioral symptoms of ASD.

METHODS:
After we completed the intervention phase of the original trial (2011-2013), many caregivers used over-the-counter dietary SF supplements in order to attempt to maintain improvements similar to those noted during the intervention. We periodically followed the progress of study participants through the summer of 2016.

RESULTS:
Families of 16 of the 26 subjects who received SF as part of the original study responded to requests for further information. Of these subjects, 6 did not continue taking SF supplements after the study. Nine of the 16 subjects are still taking an SF supplement and a 10th planned to. We present the edited testimonials of their caregivers in this case series.

CONCLUSIONS:
Many parents and caregivers articulated the positive effects of SF, both during the intervention phase and in the ensuing 3 years reported herein. These observations may contribute to understanding ASD and to treatments that may alleviate some of its symptoms. Diet- and supplement-based therapies deserve careful consideration for their potential to provide vital clinical as well as biochemical information about ASD.

KEYWORDS:
glucoraphanin; glucosinolate; isothiocyanate; prevention

The same group is currently finishing a larger trial with 50 boys and girls (3-12 years):
Sulforaphane Treatment of Children With Autism Spectrum Disorder (ASD) - Full Text View - ClinicalTrials.gov

Just two months ago, they published preliminary results in a conference proceeding. They report that 64% of the children receiving sulforaphane were much or very much improved after 30 weeks:

April 10, 2018; 90 (15 Supplement) APRIL 22, 2018
Sulforaphane Treatment of Children with Autism Spectrum Disorder (ASD) – A Progress Report (N1.002)
Andrew Zimmerman, Eileen Diggins, Susan Connors, Kanwaljit Singh
First published April 9, 2018,


Abstract
Objective: Study the safety, clinical effects and mechanisms of action of sulforaphane in ASD.

Background: Direct treatment of underlying mechanisms in ASD is limited. The “fever effect” in ASD, in which febrile illness temporarily ameliorates disordered behavior, may offer a clinical clue. Fever stimulates heat shock proteins (HSP) and cellular stress responses, leading to improved synaptic function and long-range connectivity. Expression of gene transcription by NFE2L2 (Nrf2), which is reduced in ASD, also increases during fever. Sulforaphane (SF), an isothiocyanate obtained from broccoli sprouts, induces HSP and Nrf2 as well as “cell-protective” responses that may benefit ASD through common cellular mechanisms underlying heterogeneous phenotypes.

Design/Methods: This is a randomized, double-blind, placebo-controlled phase-2 clinical trial to test the safety and efficacy of oral SF in 50 children (age 3–12 years) with ASD. Treatment period is 30 weeks, with study-visits at screening, 7, 15, 22, 30 and 36 weeks. The first 15 weeks are double-blind, 1:1 placebo-controlled, and the second 15 weeks are open-label with all participants receiving SF. Ohio Autism Clinical Global Impressions Scale – Severity and Improvement (OACIS-S and I), Aberrant Behavior Checklist (ABC) and Social Responsiveness Scale (SRS) are administered at each study visit. Samples are collected for clinical and research lab studies at each visit.

Results: To date, we have enrolled 46 participants in the study; 24 participants have completed the trial, and 22 are actively enrolled. A preliminary analysis of the OACIS-I showed that 26% participants were much/very much improved at 7 weeks, 38% at 15 weeks, 64% at 22 weeks, and 64% at 30 weeks. Most common adverse events so far are insomnia (17%), flatulence (15%) and constipation (13%). Enrollment is expected to be complete in November, 2017, and full results after July, 2018.

Conclusions: Our preliminary results show that sulforaphane appears to be safe and effective in children with ASD.

Study Supported by: United States Department of Defense

Disclosure: Dr. Zimmerman has nothing to disclose. Dr. Diggins has nothing to disclose. Dr. Connors has nothing to disclose. Dr. Singh has nothing to disclose.

Two further trials are currently under way. One will include 120 participants and the other 40 participants.
A 12-weeks Study to Evaluate Sulforaphane in Treatment of Autism Spectrum Disorder - Full Text View - ClinicalTrials.gov
Sulforaphane in a New Jersey (NJ) Population of Individuals With Autism - Full Text View - ClinicalTrials.gov


At the recent AutismOne conference, Dr. Jihoon Kim shared his experience on the use of sulforaphane in children with autism. Check out this video, where he presents some astonishing cases:

 

[Tarmander]

I've been reading a lot about sulforaphane and autism lately and came to the conclusion that this is probably one of the most promising treatment strategies.
In 2014, there was this randomized controlled study



Later, a follow up study was conducted on the same subjects:




The same group is currently finishing a larger trial with 50 boys and girls (3-12 years):
Sulforaphane Treatment of Children With Autism Spectrum Disorder (ASD) - Full Text View - ClinicalTrials.gov

Just two months ago, they published preliminary results in a conference proceeding. They report that 64% of the children receiving sulforaphane were much or very much improved after 30 weeks:




Two further trials are currently under way. One will include 120 participants and the other 40 participants.
A 12-weeks Study to Evaluate Sulforaphane in Treatment of Autism Spectrum Disorder - Full Text View - ClinicalTrials.gov
Sulforaphane in a New Jersey (NJ) Population of Individuals With Autism - Full Text View - ClinicalTrials.gov


At the recent AutismOne conference, Dr. Jihoon Kim shared his experience on the use of sulforaphane in children with autism. Check out this video, where he presents some astonishing cases:

That is pretty cool. I liked the red part: "After 18 wk, participants receiving placebo experienced minimal change (<3.3%), whereas those receiving sulforaphane showed substantial declines (improvement of behavior): 34% for ABC (P < 0.001, comparing treatments) and 17% for SRS scores (P = 0.017). On CGI-I, a significantly greater number of participants receiving sulforaphane had improvement in social interaction, abnormal behavior, and verbal communication (P = 0.015-0.007)."

That seems very promising. I have been looking a bit at how SP lowers DHT by speeding up its conversion to metabolites...basically seems like one of the only downsides.

 

[TreasureVibe]

Oncotarget. 2016 Sep 20; 7(38): 61403–61418.
Published online 2016 Aug 1. doi: 10.18632/oncotarget.8968
PMCID: PMC5308660
PMID: 27528021
Sulforaphane-induced apoptosis involves the type 1 IP3 receptor
Sona Hudecova,1 Jana Markova,1 Veronika Simko,2 Lucia Csaderova,2 Tibor Stracina,3 Marta Sirova,1Michaela Fojtu,3 Eliska Svastova,2 Paulina Gronesova,4 Michal Pastorek,4 Marie Novakova,3 Dana Cholujova,4Juraj Kopacek,2 Silvia Pastorekova,2 Jan Sedlak,4 and Olga Krizanova1
Author information ► Article notes ► Copyright and License information ► Disclaimer
This article has been cited by other articles in PMC.

Go to:
Abstract
In this study we show that anti-tumor effect of sulforaphane (SFN) is partially realized through the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1). This effect was verified in vitro on three different stable cell lines and also in vivo on the model of nude mice with developed tumors. Early response (6 hours) of A2780 ovarian carcinoma cells to SFN treatment involves generation of mitochondrial ROS and increased transcription of NRF2 and its downstream regulated genes including heme oxygenase 1, NAD(P)H:quinine oxidoreductase 1, and KLF9. Prolonged SFN treatment (24 hours) upregulated expression of NRF2 and IP3R1. SFN induces a time-dependent phosphorylation wave of HSP27. Use of IP3R inhibitor Xestospongin C (Xest) attenuates both SFN-induced apoptosis and the level of NRF2 protein expression. In addition, Xest partially attenuates anti-tumor effect of SFN in vivo. SFN-induced apoptosis is completely inhibited by silencing of IP3R1 gene but only partially blocked by silencing of NRF2; silencing of IP3R2 and IP3R3 had no effect on these cells. Xest inhibitor does not significantly modify SFN-induced increase in the rapid activity of ARE and AP1 responsive elements. We found that Xest effectively reverses the SFN-dependent increase of nuclear content and decrease of reticular calcium content. In addition, immunofluorescent staining with IP3R1 antibody revealed that SFN treatment induces translocation of IP3R1 to the nucleus. Our results clearly show that IP3R1 is involved in SFN-induced apoptosis through the depletion of reticular calcium and modulation of transcription factors through nuclear calcium up-regulation.

 

[ken]

Anyone want to comment on this article? Broccoli sprout compound may restore brain chemistry imbalance linked to schizophrenia

 

[Amazoniac]

- Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate sulforaphane. Present in the plant as its precursor, glucoraphanin, sulforaphane is formed through the actions of myrosinase, a β-thioglucosidase present in either the plant tissue or the mammalian microbiome. Since first isolated from broccoli and demonstrated to have cancer chemoprotective properties in rats in the early 1990s, over 3000 publications have described its efficacy in rodent disease models, underlying mechanisms of action or, to date, over 50 clinical trials examining pharmacokinetics, pharmacodynamics and disease mitigation. This review evaluates the current state of knowledge regarding the relationships between formulation (e.g., plants, sprouts, beverages, supplements), bioavailability and efficacy, and the doses of glucoraphanin and/or sulforaphane that have been used in pre-clinical and clinical studies. We pay special attention to the challenges for better integration of animal model and clinical studies, particularly with regard to selection of dose and route of administration. More effort is required to elucidate underlying mechanisms of action and to develop and validate biomarkers of pharmacodynamic action in humans. A sobering lesson is that changes in approach will be required to implement a public health paradigm for dispensing benefit across all spectrums of the global population.

 

[dabdabdab]

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial - PubMed

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial - PubMed

Sulforaphane is a redox-active natural product present in cruciferous vegetables like broccoli. Broccoli sprout-derived products are promising agents for the prevention of oxidative stress-related diseases, but some have long been suspected of thyroidal toxicity. Recent findings also raise the...

pubmed.ncbi.nlm.nih.gov