Travis
Member
- Joined
- Jul 14, 2016
- Messages
- 3,189
I think tocotrienols ought to have a different cellular disposition, perhaps associating less with the plasma membrane and more with the mitochondria—like the other prenylated molecules (i.e. coenzyme Q₁₀, vitamin K₂). Of course since the 'head' is the peroxynitrite scavenging part, you'd expect tocotrienols to work for doing that just the same. The water-soluble and nearly tailless γ-CEHC complexes peroxynitrite in other cellular spaces, and phylloquinone metabolism shows that the body can convert an alkane side-chain into a prenylated one: vitamin K₂ is normally synthesized from vitamin K₁ through a 'tail switching' procedure, and this occurs through the tailless water-soluble menadione intermediate. So I think the tocotrienols, of all types, would help to reduce the spontaneous superoxide known to be produced near mitochondria. People eating unrefined diets would have to worry less about vitamin E in general; while smokers, people with autoimmunity, people having cancer (reduces prostaglandin E₂ formation), and those eating mostly animal foods should perhaps focus a bit on γ-tocopherol specifically.@Travis is your interest due to smoking? Are tocotrienol's important?