Is Serotonin An Upper Or A Downer? The Evolution Of The Serotonergic System And Its Role In Depressi

Discussion in 'Scientific Studies' started by Logan-, Apr 6, 2019.

  1. Logan-

    Logan- Member

    Joined:
    May 26, 2018
    Messages:
    621
    Gender:
    Male
    [​IMG]

    Neurosci Biobehav Rev. 2015 Apr;51:164-88. doi: 10.1016/j.neubiorev.2015.01.018. Epub 2015 Jan 24.
    Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response.
    Andrews PW1, Bharwani A2, Lee KR2, Fox M3, Thomson JA Jr4.
    Author information
    Abstract

    The role of serotonin in depression and antidepressant treatment remains unresolved despite decades of research. In this paper, we make three major claims. First, serotonin transmission is elevated in multiple depressive phenotypes, including melancholia, a subtype associated with sustained cognition. The primary challenge to this first claim is that the direct pharmacological effect of most symptom-reducing medications, such as the selective serotonin reuptake inhibitors (SSRIs), is to increase synaptic serotonin. The second claim, which is crucial to resolving this paradox, is that the serotonergic system evolved to regulate energy. By increasing extracellular serotonin, SSRIs disrupt energy homeostasis and often worsen symptoms during acute treatment. Our third claim is that symptom reduction is not achieved by the direct pharmacological properties of SSRIs, but by the brain's compensatory responses that attempt to restore energy homeostasis. These responses take several weeks to develop, which explains why SSRIs have a therapeutic delay. We demonstrate the utility of our claims by examining what happens in animal models of melancholia and during acute and chronic SSRI treatment.

    Copyright © 2015 Elsevier Ltd. All rights reserved.

    KEYWORDS:
    Analysis; Depression; Distraction; Energy regulation; Hippocampus; Hypothalamus; Learning; Plasticity; Prefrontal cortex; Serotonin; Working memory

    Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response. - PubMed - NCBI
     
  2. OP
    Logan-

    Logan- Member

    Joined:
    May 26, 2018
    Messages:
    621
    Gender:
    Male
    From: Depression: It’s Not Your Serotonin
     
Loading...