Derpydragon234
Member
- Joined
- Oct 22, 2019
- Messages
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Factors known to increase aromatase activity include age, obesity, insulin, gonadotropins, and alcohol. Aromatase - Wikipedia
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Insulin drops SHBG which leads to negative feedback at the HPTA from increased free DHT, free testosterone, and free E2.
The increase in free testosterone leads to an increase in aromatase and 5 alpha reductase activities, which is undesirable because this causes further elevations in testosterone metabolites and increased negative feedbacks. This is typically seen in metabolic syndrome, classic secondary hypogonadism, also why testosterone boosters don’t work and why trying to lower SHBG is foolish for the most part. Insulin resistance (permanent elevation in insulin) frees up too much testosterone and that may sound nice for a bit but then everything backfires. Symptomatology akin to PCOS in women: baldness, abnormal body hair growth, skin conditions, general inflammation.
Increased gonadotropins is also interesting: studies show LH increases with stress. HCG is risky in that sense, it may force cholesterol metabolism into various stress hormones, but it can save someone from low estradiol and/or low androgen symptoms. Thorough bloodwork or DUTCH testing should be done before+during HCG therapy.
Only one way to reverse insulin resistance: Randle cycle
Very good post. Obese (no necesssarily), hairy, bald with thick and long beard is the typical metabolic syndrome phenotype from what I have noticed. Symptoms of long term hyperinsulinemia.Insulin drops SHBG which leads to negative feedback at the HPTA from increased free DHT, free testosterone, and free E2.
The increase in free testosterone leads to an increase in aromatase and 5 alpha reductase activities, which is undesirable because this causes further elevations in testosterone metabolites and increased negative feedbacks. This is typically seen in metabolic syndrome, classic secondary hypogonadism, also why testosterone boosters don’t work and why trying to lower SHBG is foolish for the most part. Insulin resistance (permanent elevation in insulin) frees up too much testosterone and that may sound nice for a bit but then everything backfires. Symptomatology akin to PCOS in women: baldness, abnormal body hair growth, skin conditions, general inflammation.
Increased gonadotropins is also interesting: studies show LH increases with stress. HCG is risky in that sense, it may force cholesterol metabolism into various stress hormones, but it can save someone from low estradiol and/or low androgen symptoms. Thorough bloodwork or DUTCH testing should be done before+during HCG therapy.
Only one way to reverse insulin resistance: Randle cycle
So more fat to carb?Insulin drops SHBG which leads to negative feedback at the HPTA from increased free DHT, free testosterone, and free E2.
The increase in free testosterone leads to an increase in aromatase and 5 alpha reductase activities, which is undesirable because this causes further elevations in testosterone metabolites and increased negative feedbacks. This is typically seen in metabolic syndrome, classic secondary hypogonadism, also why testosterone boosters don’t work and why trying to lower SHBG is foolish for the most part. Insulin resistance (permanent elevation in insulin) frees up too much testosterone and that may sound nice for a bit but then everything backfires. Symptomatology akin to PCOS in women: baldness, abnormal body hair growth, skin conditions, general inflammation.
Increased gonadotropins is also interesting: studies show LH increases with stress. HCG is risky in that sense, it may force cholesterol metabolism into various stress hormones, but it can save someone from low estradiol and/or low androgen symptoms. Thorough bloodwork or DUTCH testing should be done before+during HCG therapy.
Only one way to reverse insulin resistance: Randle cycle