Is it Crazy to take Ivermectin Every Day?

[HeyThere]

Wrong thread lol. Sorry.

 

[Gûs80]

"Ivermectin (Stromectol, Mectizan, Sklice, Heartgard) is a medication used in the treatment of several parasitic infections in humans, pets, and livestock. Together with penicillin and aspirin, ivermectin is considered by some to be one of the drugs that has had the greatest impact on the health and wellbeing of humankind."


Ivermectin uses:

- Strongyloidiasis
- Onchocerciasis
- Lymphatic Filariasis
- Head License
- Scabies (Mites)
- Rosacea
- Ticks – specifically Boophilus sp.
- Myiasis
- Trichinosis
- Disease vector control
- Malaria
- Leishmaniasis
- African trypanosomiasis (sleeping sickness)
- American trypanosomiasis (Chagas disease)
- Schistosomiasis
- Bedbugs
- Asthma
- Epilepsy
- Neurological disease
- Antiviral (e.g. HIV, dengue, encephalitis)
- Antibacterial (tuberculosis and Buruli ulcer)
- Anti-cancer
- Protects against Monosodium GlutamateInduced Excitotoxicity in the Rat
- Promotes Peripheral Nerve Regeneration during Wound Healing




"Asthma
A 2011 study investigated the impact of ivermectin on allergic asthma symptoms in mice and found that ivermectin (at 2 mg kg−1) significantly curtailed recruitment of immune cells, production of cytokines in the bronchoalveolar lavage fluids and secretion of ovalbumin-specific IgE and IgG1 in the serum. Ivermectin also suppressed mucus hypersecretion by goblet cells, establishing that ivermectin can effectively curb inflammation, such that it may be useful in treating allergic asthma and other inflammatory airway diseases.83

Epilepsy​

Nodding syndrome (NS) is a mysterious and problematic form of epilepsy that occurs in parts of South Sudan and northern Uganda. It is also endemic in a locus in Tanzania but, there, the prevalence is low and stable.84, 85 The condition has serious socioeconomic implications and, like other forms of epilepsy, generates profound social stigma.86 The obvious outward feature of NS, which afflicts children and adolescents, is a paroxysmal bout of forward and downward head movement, the nodding episodes representing epilepsy seizures.87 Children with NS display varying levels of mental retardation, often alongside notable stunted growth and failure to develop secondary sexual characteristics (hyposexual dwarfism). Affected children are outwardly healthy until the nodding episodes begin, with several dying due to uncontrolled seizures.84 The cause of NS remains unknown but there appears to be an unexplained link with Onchocerciasis infection.88, 89, 90 The African Programme for Onchocerciasis Control, which operated in the three afflicted countries, adopted mass drug administration of ivermectin in 1997. However, it was not always possible to operate in conflict-affected regions. After the civil war in northern Uganda ceased, biannual ivermectin distribution in districts affected by both Onchocerciasis and NS since 2012 has coincided with a substantial drop in the number of new NS cases. No new cases were reported in 2013, although there is no conclusive evidence to prove any connection.91

Neurological disease​

Many neurological disorders, such as motor neurone disease, arise due to cell death initiated by excessive levels of excitation in central nervous system neurons. A proposed novel therapy for these disorders involves silencing excessive neuronal activity using ivermectin. Because of its action on P2X4 receptors, ivermectin has potential with respect to preventing alcohol use disorders92 as well as for motor neurone disease.93 Indeed, in 2007, Belgian scientists applied for a patent, ‘Use of ivermectin and derivates thereof for the treatment of amyotrophic lateral sclerosis’ (Publication No.: WO/2008/034202A3), to cover ‘the use of ivermectin and analogs, to prevent, retard and ameliorate a motor neuron disease such as amyotrophic lateral sclerosis and the associated motor neuron degeneration’.

Recent work has elucidated how ivermectin binds to target receptors and helped explain its selectivity for invertebrate Cys-loop receptors. Combined with emerging genomic information, species sensitivity to ivermectin can now be predicted and the molecular basis of ivermectin resistance has become clearer. In humans, Cys-loop neurotransmitter receptors, particularly those activated by GABA, mediate rapid synaptic transmission throughout the nervous system and are crucial for intercellular communication. They are key factors in fundamental physiological processes, such as learning and memory, and in several neurological disorders, making them attractive drug targets.94 Improved understanding of the stereochemistry of ivermectin binding will facilitate the development of new lead compounds, as anthelmintics as well as treatments for a wide variety of human neurological disorders.95, 96

Antiviral (e.g. HIV, dengue, encephalitis)​

Recent research has confounded the belief, held for most of the past 40 years, that ivermectin was devoid of any antiviral characteristics. Ivermectin has been found to potently inhibit replication of the yellow fever virus, with EC50 values in the sub-nanomolar range. It also inhibits replication in several other flaviviruses, including dengue, Japanese encephalitis and tick-borne encephalitis, probably by targeting non-structural 3 helicase activity.97 Ivermectin inhibits dengue viruses and interrupts virus replication, bestowing protection against infection with all distinct virus serotypes, and has unexplored potential as a dengue antiviral.98

Ivermectin has also been demonstrated to be a potent broad-spectrum specific inhibitor of importin α/β-mediated nuclear transport and demonstrates antiviral activity against several RNA viruses by blocking the nuclear trafficking of viral proteins. It has been shown to have potent antiviral action against HIV-1 and dengue viruses, both of which are dependent on the importin protein superfamily for several key cellular processes. Ivermectin may be of import in disrupting HIV-1 integrase in HIV-1 as well as NS-5 (non-structural protein 5) polymerase in dengue viruses.99, 100

Antibacterial (tuberculosis and Buruli ulcer)​

Up until recently, avermectins were also believed to lack antibacterial activity. However, in 2012, reports emerged that ivermectin was capable of preventing infection of epithelial cells by the bacterial pathogen Chlamydia trachomatis, and to do so at doses that could be used to counter sexually transmitted or ocular infections.101 In 2013, researchers confirmed that ivermectin was bactericidal against a range of mycobacterial organisms, including multidrug resistant and extensively drug-resistant strains of Mycobacterium tuberculosis, the authors suggesting that ivermectin could be re-purposed for tuberculosis treatment. Although other researchers found that ivermectin does not possess anti-tuberculosis activity, the results were later shown to be non-comparable due to differences in testing methods, with the original findings being confirmed by further work in Japan.102, 103, 104 Unfortunately, the potential use of ivermectin for tuberculosis treatment is doubtful due to possible neurotoxicity at high dosage levels. Ivermectin was also reported to be bactericidal against M. ulcerans,105 although other researchers found no significant activity against this bacterium.106

Anti-cancer​

There is a continuously accumulating body of evidence that ivermectin may have substantial value in the treatment of a variety of cancers. The avermectins are known to possess pronounced antitumor activity,107 as well as the ability to potentiate the antitumor action of vincristine on Ehrlich carcinoma, melanoma B16 and P388 lymphoid leukemia, including the vincristine-resistant strain P388.108

Over the past few years, there have been steadily increasing reports that ivermectin may have varying uses as an anti-cancer agent, as it has been shown to exhibit both anti-cancer and anti-cancer stem cell properties. An in silico chemical genomics approach designed to predict whether any existing drugs might be useful in tackling glioblastoma, lung and breast cancer, indicated that ivermectin may be a useful compound in this respect.109

In human ovarian cancer and NF2 tumor cell lines, high-dose ivermectin inactivates protein kinase PAK1 and blocks PAK1-dependent growth. PAK proteins are essential for cytoskeletal reorganization and nuclear signaling, PAK1 being implicated in tumor genesis while inhibiting PAK1 signals induces tumor cell apoptosis (cell death).

PAK1 is essential for the growth of more than 70% of all human cancers, including breast, prostate, pancreatic, colon, gastric, lung, cervical and thyroid cancers, as well as hepatoma, glioma, melanoma, multiple myeloma and for neurofibromatosis tumors.110

Globally, breast cancer is the most common cancer among women but treatment options are few. Ivermectin suppresses breast cancer by activating cytostatic autophagy, disrupting cellular signaling in the process, probably by reducing PAK1 expression. Ivermectin-induced cytostatic autophagy also leads to suppression of tumor growth in breast cancer xenografts, causing researchers to believe there is scope for using ivermectin to inhibit breast cancer cell proliferation and that the drug is a potential treatment for breast cancer.111 Triple-negative breast cancers, which lack estrogen, progesterone and HER2 receptors, account for 10–20% of breast cancers and are associated with poor prognosis. Tests using a peptide corresponding to the SIN3 interaction domain (SID) of MAD, found that the SID peptide selectively blocks binding of SID-containing proteins to the paired α-helix domain of SIN3, resulting in epigenetic and transcriptional modulation of genes associated with epithelial–mesenchymal transition. An in silico screen identified ivermectin as a promising candidate as a paired α-helix domain-binding small molecular weight compound to inhibit SID peptide, ivermectin phenocopying the effects of SID peptide to block SIN3-paired α-helix interaction with MAD, inducing expression of CDH1 and ESR1, and restoring tamoxifen sensitivity in mass drug administration-MB-231 human and MMTV-Myc mouse triple-negative breast cancers cells in vitro. Ivermectin addition led to transcriptional modulation of genes associated with epithelial–mesenchymal transition and maintenance of a cancer stem cell phenotype in triple-negative breast cancers cells, resulting in impairment of clonogenic self-renewal in vitro and inhibition of tumor growth and metastasis in vivo.112

It has been reported that ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells and it has also been suggested that ivermectin synergizes with the chemotherapy agents cytarabine and daunorubicin to induce cell death in leukemia cells, with researchers claiming that ivermectin could be rapidly advanced into clinical trials.113 This potential has been supported by reports that ivermectin displays bioactivity against chronic lymphocytic leukemia cells and against ME-180 cervical cancer cells.114 Additionally, ivermectin has been shown to potentiate doxorubicin-induced apoptosis of drug-resistant leukemia cells in mice.115 Cancer stem cells are a key factor in cancer cells developing resistance to chemotherapies and these results indicate that a combination of chemotherapy agents plus ivermectin could potentially target and kill cancer stem cells, a paramount goal in overcoming cancer.

Ivermectin inhibits proliferation and increases apoptosis of various human cancers. Over-expression of P2X7 receptors correlates with tumor growth and metastasis. However, ATP release is linked to immunogenic cancer cell death, in addition to inflammatory responses caused by necrotic cell death. Exploiting ivermectin as a prototype agent to allosterically modulate P2X4 receptors, it should be possible to disrupt the balance between the pro-survival and cytotoxic functions of purinergic signaling in cancer cells. Ivermectin induces autophagy and release of ATP and HMGB1, key mediators of inflammation. Potentiated P2X4/P2X7 signaling can be further linked to ATP-rich tumor environments, providing an explanation of the tumor selectivity of purinergic receptor modulation, confirming ivermectin’s potential to be used for cancer immunotherapy.116 Activation of WNT-TCF signaling is implicated in multiple diseases, including cancers of the lungs and intestine, but no WNT-TCF antagonists are in clinical use. A new screening system has found that ivermectin inhibits the expression of WNT-TCF targets. It represses the levels of C-terminal β-catenin phosphoforms and of cyclin D1 in an okadaic acid-sensitive manner, indicating its action involves protein phosphatases. In vivo, ivermectin selectively inhibits TCF-dependent, but not TCF-independent, xenograft growth without side effects. Because ivermectin has an exemplary safety record, it could swiftly become a useful tool as a WNT-TCF pathway response blocker to treat WNT-TCF-dependent diseases, encompassing multiple cancers."

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations - The Journal of Antibiotics

Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo’s prestigious Kitasato...

www.nature.com

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

The movement of proteins between the cytoplasm and nucleus mediated by the importin superfamily of proteins is essential to many cellular processes, including differentiation and development, and is critical to disease states such as viral disease and oncogenesis. We recently developed a...

portlandpress.com

https://pubs.acs.org/doi/10.1021/acsomega.8b01451

 

[Birdie]

"Ivermectin (Stromectol, Mectizan, Sklice, Heartgard) is a medication used in the treatment of several parasitic infections in humans, pets, and livestock. Together with penicillin and aspirin, ivermectin is considered by some to be one of the drugs that has had the greatest impact on the health and wellbeing of humankind."


Ivermectin uses:

- Strongyloidiasis
- Onchocerciasis
- Lymphatic Filariasis
- Head License
- Scabies (Mites)
- Rosacea
- Ticks – specifically Boophilus sp.
- Myiasis
- Trichinosis
- Disease vector control
- Malaria
- Leishmaniasis
- African trypanosomiasis (sleeping sickness)
- American trypanosomiasis (Chagas disease)
- Schistosomiasis
- Bedbugs
- Asthma
- Epilepsy
- Neurological disease
- Antiviral (e.g. HIV, dengue, encephalitis)
- Antibacterial (tuberculosis and Buruli ulcer)
- Anti-cancer
- Protects against Monosodium GlutamateInduced Excitotoxicity in the Rat
- Promotes Peripheral Nerve Regeneration during Wound Healing

Great reference. Thank you.

 

[Makrosky]

Hey @Tarmander

I have been using 12mg IVM every day for 4 days and I can relate very much to your experience. Since first dose. Absolutely amazing substance.

I get very similar effects of 1 or 2 drops Diamant transdermal. However IVM seems to be more gradual as it lasts more than 24hrs without ups and downs, and also seems to be more systemic prometabolic than Diamant which seems to be more only on the psychic part. Difficult to explain. But very similar anyway.

I will not take it every day just in case, I don't have enough information about its safety. But it is a wonderful substance. No doubt it.

I have used it in the hopes of curing some chronic cough I had since I got covid. Didn't help with that though.

Wanted to share this.

 

[Tarmander]

Hey @Tarmander

I have been using 12mg IVM every day for 4 days and I can relate very much to your experience. Since first dose. Absolutely amazing substance.

I get very similar effects of 1 or 2 drops Diamant transdermal. However IVM seems to be more gradual as it lasts more than 24hrs without ups and downs, and also seems to be more systemic prometabolic than Diamant which seems to be more only on the psychic part. Difficult to explain. But very similar anyway.

I will not take it every day just in case, I don't have enough information about its safety. But it is a wonderful substance. No doubt it.

I have used it in the hopes of curing some chronic cough I had since I got covid. Didn't help with that though.

Wanted to share this.

Thanks for sharing man. I still take it, usually 5 days a week. Been around a year now. No problems with side effects or anything. Amazing stuff. When I started lifting weights and walking more, I noticed its effects less.

 

[sugarisgreat]

View attachment 30827

This is a great chart. Thanks.

 

[Smelly5]

Thanks for sharing man. I still take it, usually 5 days a week. Been around a year now. No problems with side effects or anything. Amazing stuff. When I started lifting weights and walking more, I noticed its effects less.

Tarmander, is there any insights that you're aware of on what the rare neurological complications of this drug are related to?

I've heard from one practionier that potentially if it's taken while there's parasites eggs in the body, it needs to be taken at the right time of their life cycle, otherwise it could eg. encourage eggs to hatch in the brain if they resided there. This is just one thing I've heard.

 

[Tarmander]

Tarmander, is there any insights that you're aware of on what the rare neurological complications of this drug are related to?

I've heard from one practionier that potentially if it's taken while there's parasites eggs in the body, it needs to be taken at the right time of their life cycle, otherwise it could eg. encourage eggs to hatch in the brain if they resided there. This is just one thing I've heard.

Nope, haven't heard of that

 

[Smelly5]

What are the theories of the mechanisms so far as to why its given you these benefits?

 

[Perry Staltic]

What are the theories of the mechanisms so far as to why its given you these benefits?

The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article

https://www.scstatehouse.gov/CommitteeInfo/SenateMedicalAffairsCommittee/The%20mechanisms%20of%20action%20of%20Ivermectin%20against%20SARS-CoV-2.pdf

 

[LadyRae]

What are the theories of the mechanisms so far as to why its given you these benefits?

Ray has mentioned that Ivermectin is anti-inflammatory...

 

[peatmoss]

@Tarmander I was curious what your daily diet/supplement/routine is lately? Any ground breaking things that have been helping you?

 

[Dutchie]

I've been pondering of trying IVM, because I suspect parasites and bacterial dysbiosis have been plagueing me for who knows how long and causing me all kinds of issues.
In the first week of using cds, I saa a worm 2x....after that no more and I felt the cds wasn't working , in a good way, anymore.

I can't get the horse paste. I however have found someone who sells drops of 'energized IVM'.
Whatever the energized part means....would it be possibly worthwhile?

 

[LadyRae]

I've been pondering of trying IVM, because I suspect parasites and bacterial dysbiosis have been plagueing me for who knows how long and causing me all kinds of issues.
In the first week of using cds, I saa a worm 2x....after that no more and I felt the cds wasn't working , in a good way, anymore.

I can't get the horse paste. I however have found someone who sells drops of 'energized IVM'.
Whatever the energized part means....would it be possibly worthwhile?

It is quite safe in my opinion. I'm not sure what the energized part means.... The anti-inflammatory benefits are really quite nice, I just took some more Ivermectin paste this morning....

 

[Tarmander]

@Tarmander I was curious what your daily diet/supplement/routine is lately? Any ground breaking things that have been helping you?

yes. I am actually going to be recording a new podcast about something I have been experimenting with for 8 months. Should come out maybe this weekend.

Daily I take Lumbrokinase, olmesartan, IVM, undecylenic acid, triphala, iron (lately have had lower levels due to exercise), CLA, myo-innositol, and Selenium

 

[peatmoss]

@Tarmander funny, i had it typed out asking you if you would do another podcast but i deleted it cause i didnt want to be pushy haha. I feel like my diet needs adjusted and i dont know where to turn. I'll be eager to hear what you have been eating!

 

[Tarmander]

@Tarmander funny, i had it typed out asking you if you would do another podcast but i deleted it cause i didnt want to be pushy haha. I feel like my diet needs adjusted and i dont know where to turn. I'll be eager to hear what you have been eating!

Won't really be about diet, but a new drug I have been testing.

Diet I am doing lots of meat/raw meat. Still on the low vitamin A train, just not as strict.

This is a normal day for me

 

[Dutchie]

It is quite safe in my opinion. I'm not sure what the energized part means.... The anti-inflammatory benefits are really quite nice, I just took some more Ivermectin paste this morning....

Woops....I'd read it wrong, it doesn't say energized....it's vitalised IVM, whatever that might mean.
I'm just kinda hesitant bc of other added ingredients in the paste, pills etc.

I also read on most sites that it gets rid of (parasitic) worms (not their eggs though), but what about other parasites and less favourable bacteria (sibo, libo)?

 

[LadyRae]

Woops....I'd read it wrong, it doesn't say energized....it's vitalised IVM, whatever that might mean.
I'm just kinda hesitant bc of other added ingredients in the paste, pills etc.

I also read on most sites that it gets rid of (parasitic) worms (not their eggs though), but what about other parasites and less favourable bacteria (sibo, libo)?

While researching the mode of action of ivermectin against Demodex mites, which are associated with rosacea, apparently there are many bacteria that live alongside parasites. Ivermectin works by inhibiting proteins in their structure so they can't reproduce. Of course this is a crude explanation so, someone else may be able to elaborate...

Ray Peat and others have commented on the anti-inflammatory actions of ivermectin and I'd like to know more about this mode of action...

@Tarmander has a lot of experience with regular use of ivermectin and there is an interesting thread that he started. He mentions the general feel of euphoria after taking it and I have to agree that I get this as well. My body and my face feel warm and cozy and I feel relaxed and calm. Bowel movements are increased but not in a flushing type of manner LOL. Every day I make sure to have a large carrot salad around 11:00 a.m. away from my breakfast and lunch.

Honestly I have never felt better. My skin is super smooth and glowy. My sleep is deep and refreshing.

You mentioned sibo. Four or five years ago I was vegan for a while and eating lots and lots of fibrous high volume foods. Along with some intermittent fasting and my belly started to bloat really bad after meals. It took years to deal with this issue, bringing back animals sources of food helped and smaller meals throughout the day helped... I did take a round of bactrim back then which I think helped me out a lot. But just cutting way back on fibrous vegetables and toning down my exercise and getting enough sleep has really helped.

That said, and I'm not trying to brag or anything, but in the six months or so since I have been taking Ivermectin intermittently, my stomach is so incredibly flat. I am a 45 year old mother of four and I actually have visible veins on my lower abs! No gas or bloating anymore. It's really a relief and I definitely think that pharmaceutical drugs have a place now and then even in the "cleanest" lifestyles.

 

[Dutchie]

While researching the mode of action of ivermectin against Demodex mites, which are associated with rosacea, apparently there are many bacteria that live alongside parasites. Ivermectin works by inhibiting proteins in their structure so they can't reproduce. Of course this is a crude explanation so, someone else may be able to elaborate...

Ray Peat and others have commented on the anti-inflammatory actions of ivermectin and I'd like to know more about this mode of action...

@Tarmander has a lot of experience with regular use of ivermectin and there is an interesting thread that he started. He mentions the general feel of euphoria after taking it and I have to agree that I get this as well. My body and my face feel warm and cozy and I feel relaxed and calm. Bowel movements are increased but not in a flushing type of manner LOL. Every day I make sure to have a large carrot salad around 11:00 a.m. away from my breakfast and lunch.

Honestly I have never felt better. My skin is super smooth and glowy. My sleep is deep and refreshing.

You mentioned sibo. Four or five years ago I was vegan for a while and eating lots and lots of fibrous high volume foods. Along with some intermittent fasting and my belly started to bloat really bad after meals. It took years to deal with this issue, bringing back animals sources of food helped and smaller meals throughout the day helped... I did take a round of bactrim back then which I think helped me out a lot. But just cutting way back on fibrous vegetables and toning down my exercise and getting enough sleep has really helped.

That said, and I'm not trying to brag or anything, but in the six months or so since I have been taking Ivermectin intermittently, my stomach is so incredibly flat. I am a 45 year old mother of four and I actually have visible veins on my lower abs! No gas or bloating anymore. It's really a relief and I definitely think that pharmaceutical drugs have a place now and then even in the
"cleanest" lifestyles.

Thanks for your 'IVM testimonial'

My issues are likely a cummulation of things and 'critters' (parasites,bacteria...about 2 months ago treated for Lyme) and I suspect MCAS, so who knows all of what I'm hosting inside... (Too broke to test everything and we don't even have certain tests).
I've already been on (increasing) restricted foods, but around Summer it suddenly all turned very bad (afraid to leave the house bc of sudden uncontrolable 'poop attacks' while I've mostly dealt with constipation. On top of generally feeling bad in sunlight).
Anyway, bc of all this I've now been eating (low histamine) carnivorish for a couple of months. While it is somewhat of a relief, I still need to take a ton of supplements in order to function/have a BM.
This week I decided to eat some goatcheese again (which is moderate histamine) and since my calves broke out in a rash with painful blisters.

Like I said, I suspect mcas (going by several 'peculiar issues' according to the docs I saw at the time) are on a rampage....BUT mcas can be triggered by underlying infection(s).
(I've been wanting to make a thread for help/possible insights,but it's such a long detailed story, that I just can't make a coherent short story out).
So, it's a case of chicken and the egg...which came first and is the actual rootcause.
I DO know that I need to sweep all possible critters out....I am DONE with hosting them.

Btw....do you also use some kind of binder with the IVM.