Is Aspirin Estrogenic?

Discussion in 'Aspirin' started by Coderr, Aug 29, 2020.

  1. Coderr

    Coderr Member

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    I get different answers on this subject. What's the final verdict?
     
  2. ecstatichamster

    ecstatichamster Member

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    I don't think so. I think it increases testosterone though.
     
  3. mrchibbs

    mrchibbs Member

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    There's a gazillion posts on the topic. It's an AI, so it can hardly be estrogenic.
     
  4. ebs

    ebs Member

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    It makes me agitated and anxious but I suspect that may be because of gaba antagonism.
     
  5. Hgreen56

    Hgreen56 Member

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    source?
     
  6. LeeLemonoil

    LeeLemonoil Member

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    Lowers cortisol, increases dopamine and steroidgenesis. The pubmed is your friend
     
  7. opethfeldt

    opethfeldt Member

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    Search the forum. There's a post about it.
     
  8. michael94

    michael94 Member

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    Yea some people don't respond as well to it, I only benefit from aspirin if I feel my metabolism is warm already. If I'm cold or tired I generally feel worse with aspirin. Doesn't mean it's doing harm per se but perhaps it requires some amount of liver warmness to not cause a stress reaction ( very unscientific way to put it but that's how I perceive my experience ).
     
  9. schultz

    schultz Member

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    Prostaglandins activate aromatase and aspirin inhibits prostaglandin formation. This is one way aspirin decreases estrogen synthesis.


    Aspirin, brain, and cancer
    "Vitamin E is now known to suppress COX-2, synergizing with aspirin and opposing estrogen."

    "Aspirin activates both glycolysis and mitochondrial respiration, and this means that it shifts the mitochondria away from the oxidation of fats, toward the oxidation of glucose, resulting in the increased production of carbon dioxide. Its action on the glycolytic enzyme, GAPDH, is the opposite of estrogen's."

    "Since the polyunsaturated fats and prostaglandins stimulate the expression of aromatase, the enzyme that synthesizes estrogen, aspirin decreases the production of estrogen. So many of aspirin's effects oppose those of estrogen, it would be tempting to suggest that its "basic action" is the suppression of estrogen. But I think it's more likely that both estrogen and aspirin are acting on some basic processes, in approximately opposite ways."

    Carbon monoxide, estrogen, and the medical cancer cult: January, 2005
    "Aspirin, by inhibiting the production of estrogen, of carbon monoxide, and of several cytokines and toxic lipid products, and by supporting normal respiration, helping to correct hyperglycemia, and suppressing lactate production, is an especially valuable therapy."

    "Vitamin D, by its anti-estrogenic and anti-inflammatory actions, and by suppressing FAS, parallels the effects of aspirin and caffeine in several ways."

    The GABA system, defenses, and tissue renewal: May, 2008
    "Inhibitors of estrogen synthesis are being considered for use in controlling epilepsy (Reddy, 2007), but aspirin and progesterone and thyroid can produce similar results."



    Aspirin Lowers Estrogen Levels / Load / Burden


    Regarding testosterone and aspirin:

    Inflammation, endotoxin, estrogen, and other problems: March 2006
    "Aspirin, increased levels of carbon dioxide (Ni Chonghaile, et al., 2005), and progesterone (Deroo and Archer, 2002; Kelly, et al., 2001; Allport, et al., 2001; van der Burg and van der Saag, 1996; Caldenhoven, et al., 1995) inhibit NF kappa-B, and NF kappa-B inhibits the synthesis of both testosterone (Hong, et al. ,2004) and progesterone (Allport, et al., 2001)."
     
  10. Frankdee20

    Frankdee20 Member

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    NSAIDS can lower T and I think Aspirin gets mixed in the debate
     
  11. Frankdee20

    Frankdee20 Member

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    It can use up Glycine and Vitamin C and K
     
  12. Hgreen56

    Hgreen56 Member

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    i have read some messages here that people telling that long term use have damaged there kidneys.
    i wonder how aspirin these damaging affect have and if peat has talked about that.
    i think this is more to worrying about than the estrogen effects
     
  13. mrchibbs

    mrchibbs Member

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    Great post!
     
  14. SonOfEurope

    SonOfEurope Member

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  15. SonOfEurope

    SonOfEurope Member

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    I can, from only personal experience, attest to this.

    I was on it daily 650mg but without k2 or glycine, my kidneys were clearly getting stressed as demonstrated by yellower urine and insatiable thirst every morning.

    I now use it therapeutically - one Aspirin regular (325mg) with some K2 on Mondays and Thursdays exception being only if I occasionally eat a high pufa meal on a Saturday (which I rarely do), if I don't have good quality Vit. E mixed Tocopherols available.
     
  16. OP
    Coderr

    Coderr Member

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    How much k2 do you get? What form?
     
  17. SonOfEurope

    SonOfEurope Member

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    120mcg Mk7
    120mcg MK4

    Along with each 325mg of aspirin I take.

    Edit: actually almost forgot... Diluting the 325 Acetylsalisylic acid in warm water completely helps a LOT in reducing stomach inflammation in those who've never taken Aspirin before. Just warm water and the tablet dissolves... Don't take those coated ones, they're ****.
     
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