Hi All, I wonder if taking All-rac-α-Tocopherol Acetate is overall safe or rather toxic. The All-rac-α-Tocopherol Acetate is a synthetic vitamin E and I found out that that's the form that they sell in a pharmacy when a patient is prescribed a higher dose of vitamin E (at least in Poland). It''s definitely cheaper than natural vitamin E, but I wonder if it does any good at all?
In vitro and in vivo evaluation of anticancer actions of natural and synthetic vitamin E forms - PubMed
Here they compared natural and synthetic vit E sources and they showed that: In vitro gammaT inhibited colony formation and induced apoptosis in all three cancer cell lines. AlphaT and all-rac-alphaT were less effective and all-rac-alphaTAc was ineffective. GammaT-induced apoptosis was correlated with activation of caspases-8 and -9 and down-regulation of protein expression of c-FLIP and survivin.
In vivo study 1 analyses showed that all-rac-alphaT and all-rac-alphaTAc significantly inhibited tumor growth and inhibited both visible and microscopic size lung metastases. In vivo study 2 analyses showed that alphaT and gammaT reduced tumor growth, but only gammaT reduced tumor growth significantly in comparison to control.
To me looks like gamma tocopherol have greatest benefit against cancer. The activity of All-rac-α-Tocopherol Acetate against cancer have not convinced me.
Would you guys recommend All-rac-α-Tocopherol Acetate to somone who can't afford natural vit E or rather recommend to stay away from it?
In vitro and in vivo evaluation of anticancer actions of natural and synthetic vitamin E forms - PubMed
Here they compared natural and synthetic vit E sources and they showed that: In vitro gammaT inhibited colony formation and induced apoptosis in all three cancer cell lines. AlphaT and all-rac-alphaT were less effective and all-rac-alphaTAc was ineffective. GammaT-induced apoptosis was correlated with activation of caspases-8 and -9 and down-regulation of protein expression of c-FLIP and survivin.
In vivo study 1 analyses showed that all-rac-alphaT and all-rac-alphaTAc significantly inhibited tumor growth and inhibited both visible and microscopic size lung metastases. In vivo study 2 analyses showed that alphaT and gammaT reduced tumor growth, but only gammaT reduced tumor growth significantly in comparison to control.
To me looks like gamma tocopherol have greatest benefit against cancer. The activity of All-rac-α-Tocopherol Acetate against cancer have not convinced me.
Would you guys recommend All-rac-α-Tocopherol Acetate to somone who can't afford natural vit E or rather recommend to stay away from it?
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