Interperdine 5-HT6 Antagonist Fails Stage 3 Alzheimer's Trial

[aquaman]

@haidut posted about Idalopirdine Serotonin Antagonists As Therapy For Alzheimer Disease in 2016, which failed stage 3 in Feb 2017.

Now Interperdine, another 5-HT6 antagonist, just failed stage 3 trials

Roivant receives bad news — and so does SoftBank

@haidut - thoughts?

 

[haidut]

@haidut posted about Idalopirdine Serotonin Antagonists As Therapy For Alzheimer Disease in 2016, which failed stage 3 in Feb 2017.

Now Interperdine, another 5-HT6 antagonist, just failed stage 3 trials

Roivant receives bad news — and so does SoftBank

@haidut - thoughts?

Could be dose-related. Pfizer continues to run a few other AD trials with idalopirdine and latrepirdine, which are due to report in early 2018. All of these drugs passed phase II, so it is strange that they will fail phase III. Could still be beneficial for a subset of the population as that is what phase II actually amounts to.