Interesting Facts About Cyproterone (Hair Loss)

[Adrenaline]

Cyproterone Acetate is an anti-androgen drug used for transitioning, hair loss, acne, hirsutism and so-called androgenic disorders. But when I search PubMed I found interesting mechanisms about this drug.

* First of all it strongly decreases cortisol and aldosterone and increases DHEA levels. Source

* Here another study showing that Cyproterone decreases ACTH-stimulated cortisol release.

* Cyproterone decreases active, inactive and total renin levels. Renin is the activator of renin-angiotensin-aldosterone (hypertension) system. Source

* Cyproterone strongly decreases estrone (E1) and estradiol (E2) synthesis. Source

* Another study showing that Cyproterone decreases estrone and estriol levels.

 

[Adrenaline]

Glucocorticoid receptor antagonism by cyproterone acetate and RU486. - PubMed - NCBI

I found one more. Cyproterone is a glucocorticoid receptor (cortisol) antagonist.

I think this drug works because it greatly suppresses adrenal hyperactivity. That's why it's so effective for hair loss, acne etc.

Not because anti-androgen..

 

[Soren]

Interesting. Thanks for sharing

 

[Risingfire]

It's definitely anti-adrogenic. Look at the study below.

Use of low-dosage oral cyproterone acetate as a male contraceptive. - PubMed - NCBI

Reduction in sperm quality, motility, mobility and other parameters such as testosterone.

It was taken orally. I wonder if the effects topically would be as severe...

 

[Adrenaline]

It's definitely anti-adrogenic. Look at the study below.

Use of low-dosage oral cyproterone acetate as a male contraceptive. - PubMed - NCBI

Reduction in sperm quality, motility, mobility and other parameters such as testosterone.

It was taken orally. I wonder if the effects topically would be as severe...

Dude, I didn't say it's not anti-androgenic. Read the first post.

 

[lampofred]

If something is antagonizing ACTH, cortisol, and aldosterone then it is acting a lot like progesterone.

 

[Risingfire]

Dude, I didn't say it's not anti-androgenic. Read the first post.

I know but it's very much anti-adrogenic and should be known.

If you want to castrate yourself, this is a good drug to take. I found another study with harsher side effects:

Medium dose cyproterone acetate (CPA): effects on hormone secretion and on spermatogenesis in men. - PubMed - NCBI

Basal prolactin went up by 75%

Testosterone and DHT went down by 70% and 50%, respectively.

 

[Adrenaline]

I know but it's very much anti-adrogenic and should be known.

If you want to castrate yourself, this is a good drug to take. I found another study with harsher side effects:

Medium dose cyproterone acetate (CPA): effects on hormone secretion and on spermatogenesis in men. - PubMed - NCBI

Basal prolactin went up by 75%

Testosterone and DHT went down by 70% and 50%, respectively.

My point is not promoting this drug. I just want to show that beside it's anti-androgenic effect it also have strong adrenal suppressive mechanism. Which explains why it works.

 

[Kunstruct]

This is an interesting subject, but should have posted the Testosterone, DHT and Prolactine massive reduced values also.

Things are really complicated, I am sure some will say Bi-Estro brings hair back if applied on the scalp.