Intercellular Zinc Deficiency a primary accelerator of aging!

[GorillaHead]

Is aging inevitable? The intracellular zinc deficiency hypothesis of aging - PubMed

A review of the literature suggests that an intracellular zinc deficiency may be the primary cause of the aging process. Zinc-metalloenzymes play an important role in many aspects of cellular metabolism including DNA replication, repair and transcription. The main enzymes affected by zinc...

pubmed.ncbi.nlm.nih.gov

Through my research I have identified that when intercellular sinc drops off low grade inflamation is triggered. This leads to the destruction of the thymus and over time apoptosis of other human organs.

This affect is most prominent in men. Their thymus will shrink faster and studies have shown zinc to be a major player.

simply taking zinc will not solve the issue.
Increasing intercellular zinc levels is key

 

[Motif]

Is aging inevitable? The intracellular zinc deficiency hypothesis of aging - PubMed

A review of the literature suggests that an intracellular zinc deficiency may be the primary cause of the aging process. Zinc-metalloenzymes play an important role in many aspects of cellular metabolism including DNA replication, repair and transcription. The main enzymes affected by zinc...

pubmed.ncbi.nlm.nih.gov

Through my research I have identified that when intercellular sinc drops off low grade inflamation is triggered. This leads to the destruction of the thymus and over time apoptosis of other human organs.

This affect is most prominent in men. Their thymus will shrink faster and studies have shown zinc to be a major player.

simply taking zinc will not solve the issue.
Increasing intercellular zinc levels is key

How to increase them?

Ps. My maybe life long zinc deficiency didn’t make me look old. I look much younger than I am.

 

[Perry Staltic]

Need selenium to release zinc from its intercellular transporter molecules so it becomes bioavailable. Zinc ionophores like quercetin and EGCG facilitate zinc entry into cells.

The body has its own transporter molecules to get zinc into and out of cells (ZIP, ZnT). I'd like to know what can be done to increase their health

 

[GorillaHead]

Need selenium to release zinc from its intercellular transporter molecules so it becomes bioavailable. Zinc ionophores like quercetin and EGCG facilitate zinc entry into cells.

The body has its own transporter molecules to get zinc into and out of cells (ZIP, ZnT). I'd like to know what can be done to increase their health

Yes this is what i heard. Reservatol as well but might be estrogenic.

vitamin D also increases cellular Zinc

Everyone should share ways to increase intercellular zinc

 

[Motif]

i took selenium , vitamin D, but that didn’t help with getting my zinc up. Never tried Quercetin longer than a few days

 

[Jam]

i took selenium , vitamin D, but that didn’t help with getting my zinc up. Never tried Quercetin longer than a few days

Did you measure via RBC zinc?

 

[Perry Staltic]

Everyone should share ways to increase intercellular zinc

Do you mean intracellular zinc? That is what the paper discusses.

 

[Perry Staltic]

i took selenium , vitamin D, but that didn’t help with getting my zinc up. Never tried Quercetin longer than a few days

Intercellular (serum) zinc is normally very low and there is no way to judge one's zinc levels from that. Most is stored in tissues

 

[Motif]

Intercellular (serum) zinc is normally very low and there is no way to judge one's zinc levels from that. Most is stored in tissues

Interesting. I measured serum and others (plasma and I don’t know other names). All low.

I’ll get my next blood test results on Monday.

My copper is also always low , no matter what test

 

[GorillaHead]

Do you mean intracellular zinc? That is what the paper discusses.

Yes

 

[GorillaHead]

Interesting. I measured serum and others (plasma and I don’t know other names). All low.

I’ll get my next blood test results on Monday.

My copper is also always low , no matter what test

Yup ur serum levels wont tell you much

 

[JohnHafterson]

Read up on carnosine and its relation to zinc:

Carnosine - an overview | ScienceDirect Topics

www.sciencedirect.com

Carnosine is a potent anti aging supplement a pleiotropic rapamycin mTor mimetic. Glycation, inflammation, very good for men.

Carnosine + Vit E

Effects of carnosine plus vitamin E and betaine treatments on oxidative stress in some tissues of aged rats - PubMed

Oxidative stress plays an important role in aging. Effects of several antioxidants on age-related oxidative stress have been investigated. Carnosine (CAR) and betaine have antioxidant actions. The combination of CAR with vitamin E(CAR+E) increases its antioxidant efficiency. We investigated the...

pubmed.ncbi.nlm.nih.gov

Carnosine pleiotropy

Carnosine and the processes of ageing - PubMed

The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its...

pubmed.ncbi.nlm.nih.gov

 

[LLight]

Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of rapamycin

Although stress can suppress growth and proliferation, cells can induce adaptive responses that allow them to maintain these functions under stress. While numerous studies have focused on the inhibitory effects of stress on cell growth, less is known ...

www.ncbi.nlm.nih.gov

SLC39A10 (a zinc transporter) could be upregulated by osmotic stress.

 

[GorillaHead]

Read up on carnosine and its relation to zinc:

Carnosine - an overview | ScienceDirect Topics

www.sciencedirect.com

Carnosine is a potent anti aging supplement a pleiotropic rapamycin mTor mimetic. Glycation, inflammation, very good for men.

Carnosine + Vit E

Effects of carnosine plus vitamin E and betaine treatments on oxidative stress in some tissues of aged rats - PubMed

Oxidative stress plays an important role in aging. Effects of several antioxidants on age-related oxidative stress have been investigated. Carnosine (CAR) and betaine have antioxidant actions. The combination of CAR with vitamin E(CAR+E) increases its antioxidant efficiency. We investigated the...

pubmed.ncbi.nlm.nih.gov

Carnosine pleiotropy

Carnosine and the processes of ageing - PubMed

The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its...

pubmed.ncbi.nlm.nih.gov

Interesting. I wonder if zinc allows us to increase mtor and inhibit the aging and harm that comes with mtor signaling.

like increasing mtor leads to acne. And zinc blocks the acne. Effectively blocking the inflammation. perhaps high mtor activation and low zinc is the primary cause of aging

 

[Dean]

Boron seems to release zinc from storage, in my recent experience. How to get it to go where you want/need it though. Maybe it's about taking it in/releasing it in quantities the body can properly disperse.

 

[TeslaFan]

If the goal is to have zinc inside the cell, then zinc ionophores should help. I believe quercetin is one.