Interaction Between Purine (Inosine) And Benzodiazepine

High_Prob

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http://science.sciencemag.org.proxy1.athensams.net/content/sci/211/4483/725.full.pdf



Interaction between purine and benzodiazepine: Inosine reverses diazepam-induced stimulation of mouse exploratory behavior.
Crawley JN, Marangos PJ, Paul SM, Skolnick P, Goodwin FK.
Abstract
Inosine, 2-deoxyinosine, and 2-deoxyguanosine completely reversed the increase in exploratory activity elicited in mice by diazepam. The inhibition of exploratory behavior by purines occurred at doses that when given alone have no effect on exploratory behavior. 7-Methylinosine, which does not bind to the brain benzodiazepine binding site in vitro, had no effect on the diazepam-induced increase in exploratory behavior. Behavioral effects produced by various combinations of inosine and diazepam indicate that the interaction between purine and benzodiazepine is antagonistic and support the hypothesis that the naturally occurring purines function in anxiety-related behaviors that respond to benzodiazepine treatment.
 

Pointless

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According to the study they antagonize benzo receptors but don't cause anxiety at low doses.
 
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