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Intake of unsaturated fatty acids and HDL cholesterol levels

Discussion in 'Scientific Studies' started by Wilfrid, May 29, 2014.

  1. Wilfrid

    Wilfrid Member

    Nov 26, 2012
    Intake of unsaturated fatty acids and HDL cholesterol levels are associated with 
    manifestations of atopy in adults.
    Schäfer T, Ruhdorfer S, Weigl L, Wessner D, Heinrich J, Döring A, Wichmann HE,
    Ring J.
    Department of Social Medicine, University Lübeck, Germany.

    BACKGROUND: The increase in allergic diseases is still unexplained. It was
    hypothesized that the intake of unsaturated fatty acids is a contributing cause
    of this development. We investigated the relationship between serum cholesterol
    levels, intake of polyunsaturated fatty acids (PUFA) and manifestations of atopy 
    in a population-based setting. METHODS: A nested case-control study was performed
    within the population of the 3rd MONICA survey in Augsburg (Germany). The serum
    levels of total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL)
    cholesterol of 1537 adults (aged 28-78 years, response 61.4%) and the estimated
    intake of PUFA in a subset of 139 men were compared with the frequency of a
    doctor's diagnosis of asthma, allergic rhinoconjunctivitis (AR), atopic eczema
    (AE) and allergic sensitization as measured by skin prick and Radio Allergo
    Sorbent Test. FINDINGS: In bivariate analyses, we obtained a negative linear
    association between total and LDL cholesterol levels and the frequency of AR and 
    sensitization, which was no longer significant after adjustment for important
    confounders. In contrast, positive linear associations were found between HDL
    cholesterol levels and AR and AE and, furthermore, between the intake of PUFA and
    allergic sensitization in men (P<0.01). 
    After adjustment, an increasing risk for 
    atopic diseases with increasing levels of HDL cholesterol and an increasing risk 
    for allergic sensitization with increasing intakes of PUFA remained statistically
    significant. INTERPRETATION: There is indication that HDL cholesterol also plays 
    a role in the complex interaction of fat intake, metabolism and the manifestation
    of atopy in adults. These findings may contribute to the understanding of time
    trends and regional differences of allergies.


    http://libgen.org/scimag/get.php?doi=10 ... 03.01780.x