Intake of unsaturated fatty acids and HDL cholesterol levels

Wilfrid

Member
Joined
Nov 26, 2012
Messages
723
Intake of unsaturated fatty acids and HDL cholesterol levels are associated with 
manifestations of atopy in adults.
Schäfer T, Ruhdorfer S, Weigl L, Wessner D, Heinrich J, Döring A, Wichmann HE,
Ring J.
Department of Social Medicine, University Lübeck, Germany.


BACKGROUND: The increase in allergic diseases is still unexplained. It was
hypothesized that the intake of unsaturated fatty acids is a contributing cause
of this development. We investigated the relationship between serum cholesterol
levels, intake of polyunsaturated fatty acids (PUFA) and manifestations of atopy 
in a population-based setting. METHODS: A nested case-control study was performed
within the population of the 3rd MONICA survey in Augsburg (Germany). The serum
levels of total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL)
cholesterol of 1537 adults (aged 28-78 years, response 61.4%) and the estimated
intake of PUFA in a subset of 139 men were compared with the frequency of a
doctor's diagnosis of asthma, allergic rhinoconjunctivitis (AR), atopic eczema
(AE) and allergic sensitization as measured by skin prick and Radio Allergo
Sorbent Test. FINDINGS: In bivariate analyses, we obtained a negative linear
association between total and LDL cholesterol levels and the frequency of AR and 
sensitization, which was no longer significant after adjustment for important
confounders. In contrast, positive linear associations were found between HDL
cholesterol levels and AR and AE and, furthermore, between the intake of PUFA and
allergic sensitization in men (P<0.01). 
After adjustment, an increasing risk for 
atopic diseases with increasing levels of HDL cholesterol and an increasing risk 
for allergic sensitization with increasing intakes of PUFA remained statistically
significant. INTERPRETATION: There is indication that HDL cholesterol also plays 
a role in the complex interaction of fat intake, metabolism and the manifestation
of atopy in adults. These findings may contribute to the understanding of time
trends and regional differences of allergies.

Source:

http://libgen.org/scimag/get.php?doi=10 ... 03.01780.x
 

Similar threads

Back
Top Bottom