Insulin Resistance In Brain Alters Dopamine Turnover, Causes Behavioral Disorders,anxiety,Depression

[paymanz]

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. - PubMed - NCBI


Diabetes and insulin resistance are associated with altered brain imaging, depression, and increased rates of age-related cognitive impairment. Here we demonstrate that mice with a brain-specific knockout of the insulin receptor (NIRKO mice) exhibit brain mitochondrial dysfunction with reduced mitochondrial oxidative activity, increased levels of reactive oxygen species, and increased levels of lipid and protein oxidation in the striatum and nucleus accumbens. NIRKO mice also exhibit increased levels of monoamine oxidase A and B (MAO A and B) leading to increased dopamine turnover in these areas. Studies in cultured neurons and glia cells indicate that these changes in MAO A and B are a direct consequence of loss of insulin signaling. As a result, NIRKO mice develop age-related anxiety and depressive-like behaviors that can be reversed by treatment with MAO inhibitors, as well as the tricyclic antidepressant imipramine, which inhibits MAO activity and reduces oxidative stress. Thus, insulin resistance in brain induces mitochondrial and dopaminergic dysfunction leading to anxiety and depressive-like behaviors, demonstrating a potential molecular link between central insulin resistance and behavioral disorders.

https://www.sciencedaily.com/releases/2015/03/150302121504.htm

. "Preliminary studies have shown that treating people with Alzheimer's disease with insulin inhaled through the nose, which is supposed to allow more insulin to get delivered directly to the brain, might slow their changes in cognitive function," he adds. "It's obviously too early to tell, because we're looking at very early-stage research, but one could imagine that intranasal insulin might actually have some effects in anti-depression or anti-anxiety in people with diabetes."

 

[Regina]

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. - PubMed - NCBI


Diabetes and insulin resistance are associated with altered brain imaging, depression, and increased rates of age-related cognitive impairment. Here we demonstrate that mice with a brain-specific knockout of the insulin receptor (NIRKO mice) exhibit brain mitochondrial dysfunction with reduced mitochondrial oxidative activity, increased levels of reactive oxygen species, and increased levels of lipid and protein oxidation in the striatum and nucleus accumbens. NIRKO mice also exhibit increased levels of monoamine oxidase A and B (MAO A and B) leading to increased dopamine turnover in these areas. Studies in cultured neurons and glia cells indicate that these changes in MAO A and B are a direct consequence of loss of insulin signaling. As a result, NIRKO mice develop age-related anxiety and depressive-like behaviors that can be reversed by treatment with MAO inhibitors, as well as the tricyclic antidepressant imipramine, which inhibits MAO activity and reduces oxidative stress. Thus, insulin resistance in brain induces mitochondrial and dopaminergic dysfunction leading to anxiety and depressive-like behaviors, demonstrating a potential molecular link between central insulin resistance and behavioral disorders.

Insulin resistance in the brain, behavioral disorders: Direct link found

Does it mean diabetes can be cured by MAO inhibitors?

 

[GAF]

What does dopamine turnover mean?

Too much d? Too little d? Or d is inactivated before it can do its thing? Anybody know?

 

[paymanz]

Does it mean diabetes can be cured by MAO inhibitors?

I'm not sure about that,MAOIs may also increase serotonin levels,isn't that?!

What made these studies interesting for me was the coonection between insulin and brain function, maybe what we need to do is to improve insulin level/sensitivity in body.

Its impaired insulin function that caused these abnormal MAO/dopamine levels,in this study!

 

[jet9]

Does it mean diabetes can be cured by MAO inhibitors?

Not sure about curing diabetes, but from my experience rhodiola rosea did improve my response to carbs. Problem is that tolerance kicks in quickly and it needs to be cycled.