Inhibitory effect of prolactin on Toxoplasma proliferation

[ursidae]

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Despite many years of studies on the mechanisms of immunological defence responses induced in host organisms by Toxoplasma, no satisfactory immunoprophylaxis or chemotherapy have yet been established for humans. Thus, alternative methods to prevent toxoplasmosis and to enhance the efficacy of currently used antitoxoplasmic drugs are under evaluation. In this work, we strove to determine the influence of human prolactin (endogenous present in serum – sPRL and recombinant – rhPRL) on the course of Toxoplasma infection of peripheral blood mononuclear cells (PBMC) originating from female hyperprolactinemia patients. This study revealed that exogenous rhPRL as well as autologous sPRL from inactivated sera significantly restricted intracellular growth of Toxoplasma in PBMC cultures. Moreover, analysis of IL-10 production by PBMC infected with Toxoplasma and cultured in the presence of sPRL showed a positive correlation between sPRL concentration and the level of IL-10. The obtained results could indicate the possible protective action of PRL in a host organism infected with Toxoplasma and suggest that a significant increase in the serum PRL level, during pregnancy for instance, might significantly limit the risk of Toxoplasma spreading and could play an important role in natural protection against toxoplasmosis. The mechanism of inhibitory effect of PRL needs further detailed study.

 

[ursidae]

Two case reports of pituitary adenoma associated with Toxoplasma gondii infection

The involvement of the pituitary in cases of toxoplasmosis has been described in the literature only rarely. This is the first report to describe pituitary adenoma in association with Toxoplasma gondii infection. The two patients were 43 and 19 year old ...

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Two case reports of pituitary adenoma associated with Toxoplasma gondii infection


The involvement of the pituitary in cases of toxoplasmosis has been described in the literature only rarely. This is the first report to describe pituitary adenoma in association with Toxoplasma gondii infection. The two patients were 43 and 19 year old women. Radiological examination revealed tumours in the sellar region. Microscopically, the tumours consisted of small homogeneous polygonal or round cells. Toxoplasma cysts were found among the tumour cells, a finding confirmed by Toxoplasma gondiispecific antibody immunohistochemistry. The association between pituitary adenoma and toxoplasma raises the possibility that T gondii might be involved in the development of certain cases of pituitary adenoma.
Keywords: Toxoplasma gondii, aetiology, pituitary adenoma

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We report two interesting cases of prolactin producing pituitary adenoma associated with Toxoplasma gondii infection, a finding that has not been reported previously.
Case 1 was a 43 year old woman who suffered from intermittent headaches for two years, suppressed menstruation for five and a half years, and weakened eyesight for two months. A computed tomography scan showed a tumour in the pituitary fossae, which was 2.0 × 3.0 cm in size. The remaining areas of the brain were normal. There were no available hormone test results. At surgery, it was found that the tumour was well encapsulated.
Case 2 was a 19 year old woman, who was admitted to hospital as a result of recurring pituitary adenoma three and a half years after initial surgery. At this time she had suffered from intermittent headache and weakened eyesight of the left eye for six months. Menarche had not occurred. Gadolinium-DTPA (diethylenetriaminepenta-acetato) weighted magnetic resonance imaging revealed a recurring tumour of 2.08 × 1.62 × 2.80 cm. No other abnormality of the brain was found. Serum pituitary hormone test results were: follicle stimulating hormone, < 1 IU/litre; luteinising hormone, 2 IU/litre; prolactin, > 200 μg/litre; oestradiol, 1.4 μg/litre; progesterone, 1.0 μg/litre; and testosterone, 290 μg/litre. The second round of surgery found that the tumour was encapsulated. Microscopically, the tumours consisted of small polygonal and round cells with abundant eosinophilic granular cytoplasm. Tumour cell nuclei were small, with inconspicuous nucleoli and evenly distributed karyoplasm. Mitotic activity was absent. Immunohistochemistry showed that both of these tumours were prolactin producing adenomas.
Interestingly, T gondii cysts were found among the tumour cells, and were verified using T gondii specific antibody immunohistochemistry (figs 1, 22).). Inflammatory cell infiltration around the cysts could be found but was not obvious.


Cases of T gondii infection with involvement of the pituitary gland are rare, and include the opportunistic infection of patients with AIDS and congenital toxoplasmosis.1 Thus, the association of T gondii with pituitary adenoma is both new and interesting. This finding raises the possibility that toxoplasma may be involved in the development of certain cases of pituitary adenoma. The pathogenesis of pituitary adenoma is not clear and is thought to be related to multiple factors, such as hormonal imbalance, drugs, hereditary factors, irradiation, and environmental factors.2 Previous experiments in which oestrogen administration to rats stimulated hyperplasia of prolactin cells and the subsequent formation of prolactin producing adenomas showed that chronic overstimulation could contribute to the neoplastic transformation.2,3 On the other hand, exogenic prolactin can induce antiparasitic activity in microglial cells as a reaction against the T gondii infection.4Therefore, to protect against toxoplasma infection, a group of cells in the pituitary gland may proliferate to produce prolactin and thereby activate the microglial cells, and it is possible that pituitary adenoma evolves from this type of prolactin producing cell hyperplasia.
There has been some discussion in the literature about the relation between T gondiiinfection and tumours, including primary ocular tumours, meningioma, leukaemia, and lymphoma.5 However, no further research regarding the role of toxoplasma in tumorigenesis has been done.
In summary, we report two cases of pituitary adenoma associated with T gondii infection for the first time. Such an association raises the possibility that chronic overstimulation as a result of toxoplasma infection may play a role in the development of pituitary adenoma.

 

[ursidae]

My personal situation: I have high prolactin, an adenoma and just got my test back: IgG is 156.00 IU/mL (ref. Range <7.2 is negative)

 

[TeslaFan]

Is raised prolactin is a defense mechanism against toxoplasma, or is caused by it?