Ingesting Plenty Of Calcium Protects Against Cadmium Absorption And Accumulation

Amazoniac

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Members that find yourselves tripping on haidut's climax highlights when f.lux's darkroom mode sets in,

The influence of calcium content in diet on cumulation and toxicity of cadmium in the organism Review
Deficit of many important bioelements may be a cause of enhanced toxicity of heavy metals, whereas high intake of bioelements, including calcium, may protect from non-beneficial action of these metals or abolish some e€ects of their action (Maha€ey 1981; Nordberg et al. 1985; Chmielewska and Cherian 1986; Bogden et al. 1992, 1995; Wojtasik and Barylko-Pikielna 1992; Moberg Wing 1993; Tanaka et al. 1995).

In the environment the main source of cadmium exposure is, besides smoking, consumption of food and water polluted with this metal (Chmielewska and Cherian 1986; WHO 1992). Bioelements, such as calcium, iron, zinc, copper and vitamins C (ascorbic acid) and D3 (cholecalciferol) in¯uence the intestinal absorption and/or toxicity of cadmium in human and animals (Gazdzik et al. 1984; Foulkes 1985; Nordberg et al. 1985; Chmielewska and Cherian 1986; Kjellstrom 1986; Groten et al. 1991, 1992; Waalkes et al. 1991, Hudecova' and Ginter 1992, Wojtasik and Barylko-Pikielna 1992; Moberg Wing 1993; Moon 1994).

Cadmium is considered as one of the most dangerous occupational and environmental poisons.
Many toxic e€ffects of cadmium result from interactions with necessary micro- and macroelements, especially with zinc, copper, iron and calcium (Gazdzik et al. 1984; Kjellstrom 1986; Florianczyk 1995; Brzoska et al. 1997a,b,c; Jurczuk et al. 1997a,b).

Entrance of calcium from the extracellular to the intracellular environment is essential for many cellular functions (division, di€ferentiation, movement, secretion, excitation; Fujita 1986).

Land-abiding vertebrates including humans always are more deficient in calcium than animals living in seawater. The calcium concentration in seawater is increased about four times over found in the extracellular fluid of most vertebrates. Food is the source of meagre calcium intake for organisms living on land compared to fish living in calcium-rich water and constantly taking this element through the gills (Fujita 1986). Inappropriate dietary calcium intake as well as changes in metabolism of this bioelement lead to various disturbances in the organism (Fujita 1986, 1991; Marcoux et al. 1991; McCarron et al. 1994; Repke 1994; Brzoska and Moniuszko-Jakoniuk 1997).

The eficiency of cadmium absorption from the gastrointestinal tract is low; in humans the uptake is 3-7%, in experimental animals ~2% and depends on the composition of the diet, including calcium intake (Nordberg et al. 1985; Foulkes 1986). Both cadmium and calcium are absorbed in the small intestine.

An afinity of this heavy metal to CaBP is almost as great as that for calcium, the explanation to which is owing to their almost identical ion radii (Bredderman and Wasserman 1974). Calcium binding protein-cadmium complex localizes in apical cells of the epithelium of intestinal villi and causes their desquamation. As a result of this process, excessive amounts of cadmium are removed, but the eficiency of Cd removal is not suficient (Washko and Cousins 1977).
As they mentioned in the review, when there is a shortage of calcium, TSH rises and increases the synthesis of that protein to enhance the absorption of ingested calcium, but since cadmium has similar afinity for that protein, then their proportion becomes a greater concern. So, a lack of dietary calcium not only enhances cadmium absorption but also confers less opposition.

When the intake of cadmium is low, as may take place during consumption of polluted food, this element inhibits calcium transport by competition with Ca2+ ions at the sites of absorption. However, when calcium intake is large, this bioelement decreases (by competition and a mechanism dependent upon cholecalciferol) both the influence of cadmium on its own absorption and absorption of this heavy metal.

Deficit of calcium in the diet also influences the distribution of cadmium in organs.

Larsson and Piscator (1971) have shown that rats simultaneously kept on low-calcium diet and exposed to cadmium accumulated much more (~60%) of this heavy metal in liver and kidneys in comparison to animals exposed to the same cadmium level in combination with a normal level of calcium in the diet.

Phytate is a rich source of phosphate: excessive phosphate intake is well known to reduce bioavailability and absorption of calcium by reason of precipitation of phosphate by calcium.
And the same process happens.

It is known that the young organisms absorb more cadmium from the gastrointestinal tract and are more sensitive to its action in comparison to the adult.

It needs to be emphasized, that calcium is only one, though very significant of many components, which influence the absorption and/or cumulation of cadmium. Therefore the composition of the diet is also very important.

The enhanced intake of calcium decreases absorption and retention of cadmium in the organism and may delay and alleviate the toxic action of this heavy metal.

Supplemental calcium appears to correct a deficit in calcium handling characterized by a renal calcium leak, increased circulating parathyroid hormone and increased intracellular calcium levels. The protective eff€ect of a calcium-rich diet against cadmium-induced hypertension seems to be connected with normalization of intracellular Ca2+ homeostasis.

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Some people take insane amounts of calcium and I doubt that it's safe. For example, here are some female members of the Ray Peat Forum after months of supplementing 5g of calcium from eggshells per day. Speaking of eggshells, for those that are still crafting coral reefs in the intestines, I suggested that you use pigments to enrichen it: turmeric, beets, papaya, spinach, paprika, etc.
 
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Makrosky

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hahahahahahaah Amazoniac all I can say is that you made me laugh a lot with the females creating psychedelic coral barriers in their guts that glow at night when f.lux darkroom mode sets on :):
 

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