Increased salt intake leads to endothelial dysfunction?

GorillaHead

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Can anyone explain explain this to me.

excerpt from this journal

“Increased sodium intake has a direct adverse effect on endothelial cells[57-61]. Sodium promotes cutaneous lymphangiogenesis, increases endothelial cell stiffness, reduces size, surface area, volume, cytoskeleton, deformability and pliability, reduces eNOS and NO production, increases asymmetric dimethyl arginine (ADMA), oxidative stress and TGF-β. All of these abnormal vascular responses are increased in the presence of aldosterone[57-61]. These changes occur independent of BP and may be partially counteract by dietary potassium”.



so does too much salt lead to to aldosterone increase?
I know low salt increases aldosterone.
 

gaze

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Jun 13, 2019
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excess sodium without calcium in the diet can make calcium deficiency worse
 
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