Increase One's Metabolism Really

[Energyforlife]

Je ne sais plus trop quoi manger. Je suis toujours fatigué quand je me lève car je dors 8h par nuit. J'ai souvent un rhume quand je me lève. Je mets un pansement sur la bouche conformément aux conseils de Patrick McKwoen.

Existe-t-il de vraies solutions pour la fatigue chronique? Je ne suis pas diagnostiqué mais j'ai des départs de fatigue. Je peux faire du sport et je me sens mieux quand je suis dehors, donc ce n'est pas un niveau de fatigue élevé.
Juste au moment où je me lève, je n'ai pas la grande énergie d'un homme de 30 ans.

 

[LLight]

Existe-t-il de vraies solutions pour la fatigue chronique? Je ne suis pas diagnostiqué mais j'ai des départs de fatigue. Je peux faire du sport et je me sens mieux quand je suis dehors, donc ce n'est pas un niveau de fatigue élevé.
Juste au moment où je me lève, je n'ai pas la grande énergie d'un homme de 30 ans.

Le diagnostique du syndrome de fatigue chronique (SFC) est basé sur une exclusion des autres pathologies qui pourraient expliquer les symptômes de fatigue.

Une caractéristique systématique du SFC est une absence de récupération après un effort physique. Du genre, la personne est très fatiguée le lendemain d'une séance d'exercice. Tu n'as pas l'air de présenter ce genre de symptômes donc ce n'est probablement pas le cas, après, tu n'as pas non plus un niveau de fatigue te forçant à rester alité donc tu as peut être juste une "version très légère".

Il n'y a pas de solution officielle au SFC mais il y a un certain nombre de témoignages de guérison même si cela reste très minoritaire.

Selon moi, les suppléments qui pourraient t'aider dans le cas où tu aurais réellement un SFC:
- la vitamine B1, il y a des études qui montrent que cela peut améliorer les symptômes de fatigue, les gens rapportent de bon résultats avec un supplément qui s'appelle de l'Allithiamine,
- le bore, pas mal de témoignages d'amélioration de la fatigue sur internet, et c'est un élément qui a une propriété antifongique naturelle (ta mycose pourrait potentiellement indiqué une carence). Par exemple, on sait que les micro-organismes fongiques sont impliqués dans certains problèmes articulaires et on sait que la supplémentation en bore peut être un remède.

Ces deux substances pourraient avoir un rôle dans la gestion du stress osmotique par le corps, ce stress étant mal géré par les personnes atteintes du SFC selon une étude récente.

As-tu des moisissures chez toi ? Elles peuvent être très toxiques et avoir un impact sur ta santé (elles sont connues pour causer des symptômes de fatigues voire même des maladies du type Alzheimer).

 

[Energyforlife]

I have nail fungus and jock itch.
I have these skin problems for 14 years.

I'm looking for habits of life to have because it seems complicated to me procrastinates quickly enough to look on the internet and do nothing.

Whenever I take sugar or fruit I may feel like scratching at the crotch.
I am also very tired after having sex with big bellyaches.

 

[Energyforlife]

After a physical effort, I recover well. If I'm going to run, for example, I'll even have more energy.
But I feel that I need to find a way of life a routine that works.
On the sfc groups they talk a lot about the ketogenic diet. Notably on the website of dr mc hill sfc specialist.
I would like to find a good time for all the good nutrition to be healthy and with energy.

 

[LLight]

I have nail fungus and jock itch.
I have these skin problems for 14 years.

I'm looking for habits of life to have because it seems complicated to me procrastinates quickly enough to look on the internet and do nothing.

Whenever I take sugar or fruit I may feel like scratching at the crotch.
I am also very tired after having sex with big bellyaches.

You probably have fungal infection, you need boron.

dusting off an old correspondence with our long missed pal @Travis.


"Boron does seem to help retain calcium, but I think this has more to do with retention than with absorption. I think boron stops the progression of calcium loss from the bones, leading to an apparent mean increase in 'calcium retention.' While its true that boron can be found in bones, it has more affinity for carbohydrates and fluorine ions (F⁻) than anything. Let me explain:

Boron exists in aqueous solution primarily as boric acid, outnumbering the deprotonated borate about 68∶1 at pH 7.4.

Now this is not a strong acid at all, much weaker than ascorbic and lactic acids. This is entirely safe to consume throughout the milligram range, only leading to toxicity as one approached double-digit gram-sized doses. Sodium borate actually has a higher LD₅₀ than sodium chloride, by mass, and it had been freely used as a preservative in all foods besides milk between the years c. 1870–1950.

[1] Nielsen, F. H. "The saga of boron in food: from a banished food preservative to a beneficial nutrient for humans." Current topics in plant biochemistry and physiology (1991)

Boric acid's most characteristic interactions are with cis-diols and fluoride, forming and molecules such as boron trifluoride and complexes like fructoborate (shown below). Besides its well-known role in reversing and preventing arthritis, borates are also known as partial antidotes to fluoride (F⁻).

The bone loss observed in rheumatoid arthritis is officially stated as being immunological in nature, and rheumatoid arthritis is officially considered an 'autoimmune disease.' This officially makes the arthritic bone loss observed in arthritis a result of an autoimmunological mechanism, somewhat like a 'confused immune system attacking the joints.' I mostly disagree with these ideas, yet instead maintain that rheumatoid arthritis is characterized by an intentional attack against synovial fungi. This is supported by observations such as: (1) the known propensity of fungi for joints; (2) the 'die-off' reaction seen in the majority of arthritic patients after taking borates; (3) the well-established inhibition of fungi at physiologically-achievable borate concentrations; and (4) the strong correlations between rheumatoid arthritis and YKL-40, a chitin-binding protein released by neutrophils and macrophages. Since mammals don't make chitin—e.g. only shellfish, yeast, fungi, and insects do—then specific chitinase enzymes and chitin-binding proteins released by immune cells can only rightly be seen as immunological defenses against yeast & fungi.

[1] Cuellar, M. "Fungal arthritis." Annals of the rheumatic diseases (1992)

[2] Newnham, E. R. "Supplement to the art of getting well boron and arthritis." The arthritis Trust of America (1994)

[3] Pointer, B. "Boric acid destabilizes the hyphal cytoskeleton and inhibits invasive growth of Candida albicans." Yeast (2015)

[4] Johansen, J. S. "A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid." Rheumatology (1993)

Assuming Dr. Newnham is correct in his observations—i.e. that 70% of arthritic patients taking boron initially experience a 'herxheimer reaction'—than a person could assume that fungi in synovial fluid is far more prevalent than commonly assumed. I do take this view, and can see no other reason for an initial increase in joint pain before the indefinite remission. Proceeding under this view, the bone loss observed in rheumatoid arthritis can be explained by two enzymes: (1) neutrophil NADPH oxidase and (2) Aspergillus carbonic anhydrase. Both of these enzymes have acidic protons (H⁺) as products, and carbonic anhydrase II is known as the bone-dissolving enzyme of osteoclasts.

[1] Borregaard, N. "Proton secretion by stimulated neutrophils. Significance of hexose monophosphate shunt activity as source of electrons and protons for the respiratory burst." The Journal of clinical investigation (1984)

[2] Tobal, J. "Role of carbonic anhydrases in pathogenic micro-organisms: a focus on Aspergillus fumigatus." Journal of medical microbiology (2014)

Stopping calcium loss from the bones then becomes synonymous with destroying fungi, in many cases, and nothing does this better and safer than borates. This works on a more fundamental level than even potassium iodide—which needs neutrophil or eosinophil myeloperoxidase to become hypoiodite (IO⁻) first—because boric acid appears to directly crosslink chitin. Although it can react with the host's monosaccharides and polysaccharides, to an extent, it cannot crosslink them to a significant degree due their extensive spacing and different bonding arrangements. I maintain that borates crosslink both chitin and cellulose, reliably, which are two β-linked polysaccharides arranged in sheets.

Chemical engineers have crosslinked boric acid with chitosan, or deacetylated chitin, at standard temperature and pH. Cellulose can be similarly crosslinked by boric acid, as evidenced by the changes it induces on cotton textiles and wood. These facts explaining why borax is found in the laundry aisle, and also why it's sold commercially as a fire retardant for cellulosic materials.

The use of borax as as insecticide can be explained by the presence of chitin in the intestinal tract of cockroaches, an observation known since the 1920s. A 2% boric acid solution can dissolve the intestines of the German cockroach, concentrations completely innocuous to bacteria and mammals. I personally have consumed 20 ounces of supersaturated borax water, equating to a 3% concentration of boric acid.

[1] Sricharussin, W. "Effect of boric acid and BTCA on tensile strength loss of finished cotton fabrics." Textile Research Journal (2004)

[2] Kawamoto, H. "Inhibition of acid-catalyzed depolymerization of cellulose with boric acid in non-aqueous acidic media." Carbohydrate research (2008)

[3] Saita, K. "Preparation and characterization of dispersible chitosan particles with borate crosslinking and their antimicrobial and antifungal activity." Carbohydrate research (2012)

[4] Hirata, T. "Thermal analysis of cellulose treated with boric acid or ammonium phosphate in varied oxygen atmospheres." Journal of applied polymer science (1987)

[5] Ling, Z. "Boric acid-mediated B, N-codoped chitosan-derived porous carbons with a high surface area and greatly improved supercapacitor performance." Nanoscale (2015)

[6] Campbell, F. L. "The detection and estimation of insect chitin; and the irrelation of “chitinization” to hardness and pigmentation of the cuticula of the American cockroach, Periplaneta americana L." Annals of the Entomological Society of America (1929)

[7] Cochran, D. G. "Toxic effects of boric acid on the German cockroach." Experientia (1995)

[8] Habes, D. "Boric acid toxicity to the German cockroach, Blattella germanica: Alterations in midgut structure, and acetylcholinesterase and glutathione S-transferase activity." Pesticide Biochemistry and Physiology (2006)

Every known indication of borates are to modify materials containing either chitin or cellulose—e.g. wood, paper, cotton, insects, fungi, yeast—two sheetlike β-polysaccharides it is assumed to reliably crosslink. Doctor Newnham's patients testify that the most pronounced effect of borates is antifungal in nature, an effect they've been shown to exert in vitro on two dimorphic fungal species. Monomorphs such as Aspergillus could be presumed to be even more sensitive, being inherently higher in chitin and not having a round yeast form to default to.

[1] Pointer, B. "Boric acid destabilizes the hyphal cytoskeleton and inhibits invasive growth of Candida albicans." Yeast (2015)

[2] Schmidt, M. "Boric acid disturbs cell wall synthesis in Saccharomyces cerevisiae." International journal of microbiology (2010)

[3] Bowen, J. "Nonessentiality of boron in fungi and the nature of its toxicity." Plant physiology (1966)

In the absence of invasive yeast and fungal forms, boron can still be seen as beneficial—both for its strengthening effect and ability to inhibit future colonization. Borates are freely incorporated into bone where it can be found in concentrations exceeding most bodily fluids and tissues; synovial tissue is an ultrafiltrate of plasma, and boron concentrations between the two would be proportional. The high concentrations found in urine exemplify the ease in which any excess is eliminated.

As a result of rat feeding studies, borate appears to slightly increase bone compressive strength while slightly decreasing shear strength. Yet since the gain in compressibility exceeds the loss of shear strength, so you could see borate as exerting a net positive benefit. Moreover: bones are constructed to support body weight by compression, with shear strength coming into play only during trauma.

[1] Chapin, R. "The effects of dietary boron on bone strength in rats." Toxicological Sciences (1997)

[2] Ward, N. I. "The determination of boron in biological materials by neutron irradiation and prompt gamma-ray spectrometry." Journal of Radioanalytical and Nuclear Chemistry (1987)

[3] McCoy, H. "Relation of boron to the composition and mechanical properties of bone." Environmental health perspectives (1994)

Although boron does have idiosyncratic lubricative properties, I assume that fungal arthritis is common enough in America that its antifungal effect should be seen as primary. Borates are known to inhibit enzymes, yet the concentrations needed are unphysiological in all cases. Although boric acid may bind some human polysaccharides it certainly does not bind them all, for instance: boric acid does not react with hyaluronic acid, the polysaccharide component of synovial fluid responsible for lubrication. Although this contains N-acetylglucosamine, like chitin, it is α-linked and not β-linked in this case. Hyaluronic acid also alternates with glucuronic acid, while chitin is composed of all N-acetylglucosamine. This monosaccharide is a powerful growth factor for yeast and fungi, perhaps not surprising when considering the composition of chitin.

'The requirement for specific groupings is emphasized by the fact that hyaluronic acid, which is composed of N-acetyl-D-glucosamine and D-glucuronic acid, did not react with borate.' ―Zittle (1951)

Boric acid could have some effects on the cell membrane, perhaps by: (1) increasing the ζ-potential after binding to polysaccharides, (2) increasing glucose flux by forming borate–sugar complexes, or (3) increasing ion flux via increasing membrane volume or solubility towards water. Borates also have some unique interactions with leucyl-tRNA, perhaps what could be underlying its ability to increase steroid hormones in some studies. Yet all-in-all: its effects appear relatively mild in realistic concentrations, certainly beneficial in the milligram range while providing no inherent toxicity. I personally am shooting for well-boronated bones, and have been drinking gram amounts daily. A supersaturated solution of borax at 68 °F contains 4.71 grams per litre, which equates to 3.05 grams of soluble boric acid and 280 milligrams of sodium. This is certainly not something to be afraid of, and if joints hurt after taking it you can probably infer there is fungi present. Most people take milligram sized doses, and these are available in capsule form."

Also, i asked about potential estrogenic effects of boron/borax. Here's his response:

"It would increase testosterone if anything, just as in these studies below:

Ferrando, A. "The effect of boron supplementation on lean body mass, plasma testosterone levels, and strength in male bodybuilders." International journal of sport nutrition (1993)

Green, N. "Plasma boron and the effects of boron supplementation in males." Environmental health perspectives (1994)

In females, it increases their sex hormone—estrogen. However: even in females it also increases testosterone by a proportional amount:

Nielsen, F. "Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women." The FASEB journal (1987)

This is not surprising since it slightly increases cholesterol in both sexes, perhaps by interacting with the mTOR pathway as a leucine mimetic:

Scorei, R. "A Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Effect of Calcium Fructoborate on Systemic Inflammation and Dyslipidemia Markers for Middle-Aged People with Primary Osteoarthritis." Biological Trace Element Research (2011)

Hu, Q. "Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase." Scientific reports (2013)

Boric acid, borate, fructoborate, and benzoxaboroles cannot be considered selectively estrogenic when the increase both sex steroids proportionally. These are sex-neutral compounds, likely stimulators of de novo steroid synthesis. I suppose boron can be considered 'highly estrogenic' should a person focus entirely on female studies determining only estradiol, remaining completely oblivious to the corresponding cholesterol and testosterone increases observed in both males and females. Since boron compounds don't favor one sex hormone over the other, it would be far more appropriate simply to consider them 'steroidogenic' in high doses."


He gave me a couple of gems while he was around :)

 

[Energyforlife]

que me conseillez-vous de manger?
Plus d'une semaine parce que j'ai de la difficulté à bien gérer mes repas.
Le bore est comme le borax pour les rats?
Où est-il acheté?

 

[LLight]

que me conseillez-vous de manger?
Plus d'une semaine parce que j'ai de la difficulté à bien gérer mes repas.
Le bore est comme le borax pour les rats?
Où est-il acheté?

Je conseillerais plutôt de prendre un supplément histoire d'être certain d'avoir une dose normalisée. Personnellement, j'utilise le bore de la marque Now foods.

Traduit d'un article:
"De bonnes sources de bore sont la pomme, l'avocat, le bouillon de bœuf, la tige de brocoli, les cerises, le pain blanc enrichi, les flocons de maïs enrichis, les raisins, la cannelle moulue, les kiwis, les lentilles, les noix, les olives, les oignons, les oranges, le persil, les pêches, le soja."

-> en France, le pain blanc et les flocons de maïs ne seront pas enrichis. On peut rayer le soja de la liste aussi...

PS: Je pense réellement qu'il y a une "synergie" entre le bore et la vitamine B1. Je conseillerais d'en prendre en parallèle.

"An experiment was designed to test the hypothesis that dietary boron impacts upon the function of various coenzymes involved in energy metabolism. In a 2x7 factorially-arranged experiment, weanling, vitamin D3-deprived rats were fed a ground corn-casein-corn oil based diet supplemented with 0 or 2 mg boron/kg and 50% of the requirement for thiamine (TM), riboflavin (RF), pantothenic acid (PA) or pyridoxine (PX); 0% for folic acid (FA) or nicotinic acid (NA). All vitamins were supplemented in adequate amounts in the control diet. At 8 weeks of age, the TM dietary treatment was the one most affected by supplemental dietary boron (SDB). In rats that were fed 50% TM, SDB increased plasma concentrations of triglyceride (TG) and activity of alanine transaminase (ALT), and the liver to body weight (L/B) ratio. However, in the SDB animals, adequate amounts of TM decreased the means of those variables to near that observed in non-SDB rats fed 50% TM. The findings suggest that an interaction between dietary boron and TM affects lipid metabolism."

 

[milkboi]

You guys could just write in english right?

 

[LLight]

You guys could just write in english right?

Energyforlife has expressed the fact that he has difficulties understanding english. Sorry for that.

 

[Spartan300]

Has anyone tried this approach and seen improvements?

I just ate some cocoa butter after breakfast and warmed up quite a bit. Maybe I'll eat some after every meal for a while and see what happens

 

[Spartan300]

Apologies I'd meant to reference Andre's post about Broda Barnes recommending higher fat....

 

[Indicatrice]

If you want something strange (at least for this forum), get 80% of your calories from fat. Messure temperature after a meal. It will increase and stay high all day long. By fat I mean of course no PUFA. Try cream or butter. Do it one day if you do not believe me. Ray Peat mentions quite often Broda Barnes when it comes to Thyroid. If you read Broda Barnes book "The Thyroid" you will see he is a big proponent of high fat, low carb diets as long you do not go into ketosis (it means at least 50g carbs a day) and not to much protein (1g/kg max). Protein "consumes" T3 and therefor reduces metabolism.

What would be an upper limit of daily carb intake recommended by Barnes?