Important Information For Your Doctor. PUFA Depleted Rats Are More Sensitive To Volatile Anesthesia

Joined
Aug 21, 2018
Messages
1,122
Manipulation of Rat Brain Fatty Acid Composition Alters Volatile Anesthetic Potency
A S Evers et al. J Clin Invest. Mar 1986
Abstract


The molecular mechanism of volatile anesthetic action remains unknown. Attempts to elucidate this mechanism have been complicated by the absence of models in which changes in neuronal cellular properties can be correlated with changes in whole animal anesthetic effect. In this study we describe a model where diet-induced alterations in rat brain fatty acid composition are correlated with alterations in volatile anesthetic potency. Rats maintained on a fat-free diet showed significant depletion of arachidonic acid (20:4 omega 6; 5,8,11,14-eicosatetraenoic acid) and docosahexaenoic acid (22:6 omega 3; 4,7,10,13,16,19,-docosahexaenoic acid) in brain, and a corresponding increase in Mead acid (20: 3 omega 9; 5,8,11-eicosatrienoic acid). These fat-deprived rats were significantly more sensitive to all volatile anesthetics tested than were age-controlled rats on a normal diet. Parenteral supplementation of the fat-deprived animals with linolenic acid (18: 3 omega 3, 9,12,15-octadecatrienoic acid) completely reconstituted the docosahexaenoic acid content of brain without affecting anesthetic sensitivity. In contrast, supplementation of the fat-deprived rats with linoleic acid (18: omega 6; 9,12-octadecadienoic acid) caused a dramatic decrease in anesthetic sensitivity, but only a small change in whole brain arachidonate content. Further analysis revealed that linoleate supplementation of fat-deprived animals resulted in a preferential normalization of the arachidonate content of brain phosphatidylinositol as compared with other brain phosphoglycerides. These results demonstrate for the first time a correlation between changes in membrane composition and anesthetic effect, and indicate that the precise fatty acid composition (perhaps in specific phospholipids) of brain is important in the mechanism of volatile anesthetic action.

Manipulation of Rat Brain Fatty Acid Composition Alters Volatile Anesthetic Potency - PubMed

ABSOLUTELY MUST TO MAKE YOUR ANESTHESIOLOGIST AWARE OF IT IN CASE YOU ARE GOING TO HAVE A SURGERY AND YOU ARE PUFA DEPLETED.
 

Mhtro

Member
Joined
Nov 14, 2019
Messages
48
Does this also affect the potency of GABA drugs such as benzos, meaning their sedative effect?
 

SOMO

Member
Joined
Mar 27, 2018
Messages
854
Thanks for posting this info Methylenewhite, it's actually useful and something of which I was unaware.

But if you tried to tell your anesthesiologist this before surgery, I doubt they would listen.
The doctor would think: "I didn't learn about this in medical school, it doesn't matter if you brought some study. I went to medical school and memorized the best textbooks, who do you think you are telling me how to do my job?"


Doctors are authoritarian and when you question them (or question the Standard of Care) they often shut down and stop listening or, worse, spew vitriol.
 

methylenewhite

Member
Thread starter
Joined
Aug 21, 2018
Messages
1,122
Thanks for posting this info Methylenewhite, it's actually useful and something of which I was unaware.

But if you tried to tell your anesthesiologist this before surgery, I doubt they would listen.
The doctor would think: "I didn't learn about this in medical school, it doesn't matter if you brought some study. I went to medical school and memorized the best textbooks, who do you think you are telling me how to do my job?"


Doctors are authoritarian and when you question them (or question the Standard of Care) they often shut down and stop listening or, worse, spew vitriol.

I believe an anesthesiologist would listen because there is a chance for him get a patient killed. If there is a medical information in your wallet saying volatile anesthesia hypersensitive they would be careful dosing it for sure. Probably better not to tell the PUFA thing, just higher anesthesia sensitivity.
 

BearWithMe

Member
Joined
May 19, 2017
Messages
1,002
I believe an anesthesiologist would listen because there is a chance for him get a patient killed. If there is a medical information in your wallet saying volatile anesthesia hypersensitive they would be careful dosing it for sure. Probably better not to tell the PUFA thing, just higher anesthesia sensitivity.
This x1000. The way you communicate with your doctor makes all the difference. If you are smart about it, they often listen.
 

maillol

Member
Joined
Oct 28, 2019
Messages
220
This x1000. The way you communicate with your doctor makes all the difference. If you are smart about it, they often listen.
I find most doctors are pretty open to discussion when you bring studies. I always say I've been researching at my university library rather than "the internet".
 

BearWithMe

Member
Joined
May 19, 2017
Messages
1,002
I find most doctors are pretty open to discussion when you bring studies. I always say I've been researching at my university library rather than "the internet".
Exactly. Not acting like they are dumb / you are smarter and not mentioning the word "internet" would be two most important things when communicating with your doctor.
 

Vinny

Member
Joined
Dec 11, 2018
Messages
1,179
Age
48
Location
Paphos, Cyprus
Exactly. Not acting like they are dumb / you are smarter and not mentioning the word "internet" would be two most important things when communicating with your doctor.
:handok:
 
Similar threads
Thread starter Title Forum Replies Date
Diokine 5α-reductase is important for corticoid modulation and HPA axis feedback Stress 13
Diokine Circadian T3 Method - why taking thyroid hormone at the proper time is important T3 & T4 83
U What does eggs offer to be important part of the diet? Diet 9
J Is it important to get a good quality organic/non toxic bed mattress? Body Care 1
Hgreen56 Anti-Peat Study reveals how sugars wipe out important bacteria in gut Debate - Anti-Peat 17
Hans The Most Important Organ For Longevity Articles & Scientific Studies 20
Doludolu COPPER - Very Important For Mitochondria-metabolism. Toxic Or Important - Depends On The Form Metabolism 16
Hans Counting Calories Thread: Is It Really Important? Articles & Scientific Studies 3
J Covid-19 Plan In Front Of Our Eyes IMPORTANT! Political Talk, Alternative World Theories 11
ecstatichamster Most Important Study - Shows Genetic Theories Are Completely False (involves Exosomes) Scientific Studies 0
md_a There Is An Extremely Important Connection Between ACE-inhibitor Medication For Hypertension And The Scientific Studies 3
methylenewhite Perhaps This Is Why Doctors Are Dying. Please Read. I Believe It's Important For Everyone Articles & Scientific Studies 13
md_a The Body Temperature Is Very Important Thyroid and Hormones 2
Lokzo SHBG More Important Than You Think Thyroid and Hormones 19
Jamesu How Important Is Fruit In Slowing Hairloss? Ask For Help or Advice 0
yerrag Is Stopping Regime Change Wars Not Important? Political Talk, Alternative World Theories 8
L I Think Eating According To Blood Type Might Be Very Important Discussing Dietary Models 12
ecstatichamster Announcement Here’s How To Support This Board - Important Ray Peat Forum Announcements 57
Broken man TUDCA- Important Peaty Substance? Some Studies To Think About Supplements 43
A The Most Important Things To Stop Eating While Trying To Fix Dysbiosis? Ask For Help or Advice 0
TheSir Is It More Important To Eat Enough Calories Or Get Enough Nutrients? Ask For Help or Advice 28
J The Most IMPORTANT Blood Tests To Obtain Ask For Help or Advice 2
olive Neuron Derived Estrogen Important For Memory Formation Scientific Studies 2
haidut Vitamin K Important For Eye Health Too Scientific Studies 12
ddjd Copper Important For Transport Of Vitamin A From Liver To Blood Ask For Help or Advice 1
Hans Important Hormones For Building Muscle And Tips On How To Improve Them Exercise 44
D X-rays Reveal The Important Role Of Copper In Parkinson’s Disease Scientific Studies 6
E What Is The Most Important Meal Of The Day? Ask For Help or Advice 9
General Orange Estrogen E1 More Important For Hair Than Testosteron Hair & Nails 65
S Important Question On Applying Squalane As A Moisturiser Body Care 25
Cirion What's More Important For Metabolism - HR Or Temperature? Metabolism 4
KnowledgeSeeker How I Got Invincible To Sunburns And Why PUFA Isn't The Most Important Factor In My Opinion Health 8
michael94 Important Statement On Liver Flush Cholesterol 1
L So Is The Absolute Amount Of PUFA Important Or The Proportion Of SFA To PUFA? Diet 4
H Why Is The Thyroid So Important? Metabolism 1
cyclops Is Losing Bodyfat The Most Important Thing? Diet 139
L Why The Government Thinks Guinea Pigs Are More Important Than People C 3
cyclops How Important Is Alkaline/Acid Balance Diet 8
ddjd Is Nitric Oxide Important For Sleep? Insomnia, Sleep Issues 4
Crazycoco So Much Fun With Saturated Fats Guys! Important Study! Ask For Help or Advice 3
michael94 How Important Is The Appearance Of Someone Offering Health Advice To You? Miscellaneous Health Discussions 9
ecstatichamster 2 New Important Aspirin Learnings Aspirin 51
MyUsernameHere Sleep Temperature; Why Is It So Hugely Important? Insomnia, Sleep Issues 8
D What Is The Single Most Important Hair Loss Supplement To Take? Supplements, Pharmaceutical Drugs 49
L Case Western Reserve University Research Reveals Important Cancer Clues Cancer, Degenerative Diseases 1
Black Ops Are The B-vitamins Important For Androgen Production? (Which Ones Specifically) Vitamins 10
michael94 Glucose Important Factor In Bile Acid Synthesis Macros & Micros 0
L Appendix May Have Important Function, New Research Suggests Health 13
P What Is More Important? Diet 12
P How Important Is Calcium In Relative To Phosphorus? Minerals 7

Similar threads

Top