Impact Of Gestational Bisphenol A On Oxidative Stress And Free Fatty Acids

RWilly

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"Bisphenol A (BPA) is a high production volume chemical and an endocrine disruptor. Developmental exposures to BPA have been linked to adult metabolic pathologies, but the pathways through which these disruptions occur remain unknown."

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"This is the first BPA exposure study to comprehensively combine and compare an association study in human and a targeted BPA treatment study involving 3 different mammalian species (sheep, rats, and mice). Findings from this study demonstrate a positive association between increased BPA exposure and increased systemic nitrosative stress, as well as increased palmitic acid during the first trimester of pregnancy in humans. Cord blood of subjects exposed to higher BPA levels during 8–14 weeks of gestation also had higher nitrosative stress. Complementary studies with multiple animal species treated prenatally with BPA at relevant human exposure doses provide the causal link of BPA induction of nitrosative stress."

Impact of Gestational Bisphenol A on Oxidative Stress and Free Fatty Acids: Human Association and Interspecies Animal Testing Studies
 

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