I'm Attempting Reversal Of Advanced PSC Cataracts, Feedback Appreciated

Discussion in 'Eyes, Ears, Nose and Headaches/Migraines' started by daphne134, Jul 7, 2020.

  1. OP
    daphne134

    daphne134 Member

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    Huh. So looks like I can get a home A1C test kit from CVS that measures more than just blood glucose at a given time. (Rant alert: Now I'm shock the optometrist and ophthalmologist didn't suggest this. There's multitudes of information online that thin people can be diabetic, and the only condition widely associated with cataracts is diabetes.)

    But after all these years in Peat groups I can't fathom how people even survive on keto. I guess it's possible because I have a friend who was long-term posting her daily steaks on social media. Ok will look into it further, thanks.
     
  2. Tristan Loscha

    Tristan Loscha Member

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    An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract - PubAg


    An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

    Author:
    Pietrowska, Karolina, Dmuchowska, Diana Anna, Krasnicki, Pawel, Bujalska, Aleksandra, Samczuk, Paulina, Parfieniuk, Ewa, Kowalczyk, Tomasz, Wojnar, Malgorzata, Mariak, Zofia, Kretowski, Adam, Ciborowski, Michal
    Source:
    Electrophoresis 2018 v.39 no.9-10 pp. 1233-1240
    ISSN:
    0173-0835
    Subject:
    amino acid metabolism, antioxidants, blindness, cataract, disease occurrence, electrophoresis, epidemiological studies, eyes, glycosylation, metabolomics, metformin, nicotinamide, nutrients, oxidative stress, patients, people, surgery, taurine, uric acid, xanthine
    Abstract:
    Cataract is the leading cause of blindness worldwide. Epidemiological studies revealed up to a fivefold increased prevalence of cataracts in diabetic subjects. Metabolomics is nowadays frequently implemented to understand pathophysiological processes responsible for disease occurrence and progression. It has also been used recently to study the metabolic composition of aqueous humor (AH). AH is a transparent fluid which fills the anterior and posterior chambers of the eye. It supplies nutrients and removes metabolic waste from avascular tissues in the eye. The aim of this study was to use metabolomics to compare the AH of diabetic and non‐diabetic patients undergoing cataract surgery. Several antioxidants (methyltetrahydrofolic acid, taurine, niacinamide, xanthine, and uric acid) were found decreased (−22 to −61%, p‐value 0.05–0.003) in AH of diabetics. Also amino acids (AA) and derivatives were found decreased (−21 to −36%, p‐value 0.05–0.01) while glycosylated AA increased (+75–98%, p‐value 0.03–0.009) in this group of patients. Metformin was detected in AH of people taking this drug. To our knowledge, this is the first metabolomics study aiming to assess differences in AH composition between diabetic and non‐diabetic patients with cataract. An increased oxidative stress and perturbations in amino acid metabolism in AH may be responsible for earlier cataract onset in diabetic patients.

    @daphne134

    ..'Several antioxidants (methyltetrahydrofolic acid, taurine, niacinamide, xanthine, and uric acid) were found decreased (−22 to −61%, p‐value 0.05–0.003)'
     

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  3. OP
    daphne134

    daphne134 Member

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    Yeah, I seriously can't thank you enough for this direction because I realized what I personally need is FODMAP. I've known about it vaguely since forever but for better and (mostly) worse I always need to understand how things work before I'll do something, plus my education was lacking in the area of health (surprise surprise). Ok I have a new diet to plan - happy to say more later.
     
  4. Tristan Loscha

    Tristan Loscha Member

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    ..the conversion happens endogenously from glucose, FODMAP elimination will probably not bring resolve. It is the amount of tissue carbs and overloading that is an issue.
     
  5. OP
    daphne134

    daphne134 Member

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    Ran some numbers and to be more clear (until I find a doctor) I'm currently combining keto with FODMAP. That is - limiting both amount and type of carb. Looking back, during the timespan between when my left eye could read and when it couldn't - I had gotten to a place of eating (actually, drinking) quite a lot of fructose and sorbitol and there was FOS in some medication I was taking. (And wasn't doing much dairy as I recall.)

    All the literature on fructose intolerance is laden with hand wringing and over-generalizations - but here's something interesting:

    Heterogeneity in Metabolic Responses to Dietary Fructose

    And while this isn't much to go on - this fellow in Spain is diagnosed with fructose malabsorption, and he seems not to just be talking about digestive issues:
    The opposite of healthy? Low fructose diet : Cooking

    I believe Lanomax is the only thing that might actually reverse existing damage. They've been very communicative (as much as they can be) and also have doubled the size of the $99 bottle btw. But the right conditions have to be in place of course.

    (Editing to add: I got the FODMAP idea from Chris Masterjohn's recent newsletter where he advises diabetics to look at the sweets portion of FODMAP.)
     
  6. skkya

    skkya New Member

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    How are you doing, Daphne? Has anything helped? I just read through the thread and am hoping you have had some improvement.
     
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