I'm Attempting Reversal Of Advanced PSC Cataracts, Feedback Appreciated

[LucyL]

I remember Dr Peat saying his brother (I think) had his cataracts go away after being on high-dose aspirin for some other condition. I'm not sure why the aspirin would affect cataracts, and I have no idea how you can safely take high-dose asprin or for how long. Would be nice to know these things.

"Aspirin's known anticataract effect apparently involves a similar protection of crystallin against glycation, but aspirin has several other protective effects, including prevention of protein cross-linking, and the inhibition of the synthesis of nitric oxide and prostaglandins and other disruptive materials (Crabbe, 1998; Beachy, et al., 1987; Lonchampt, et al., 1983). " -from Cataracts: water, energy, light, and aging

 

[Steve]

"Aspirin's known anticataract effect apparently involves a similar protection of crystallin against glycation, but aspirin has several other protective effects, including prevention of protein cross-linking, and the inhibition of the synthesis of nitric oxide and prostaglandins and other disruptive materials (Crabbe, 1998; Beachy, et al., 1987; Lonchampt, et al., 1983). " -from Cataracts: water, energy, light, and aging

Thank you.......now I wonder if there is a safe way to take it and how much to take. My eye dr said he could see the start of cataracts in my eyes at 49 years old, and I've been stressed and depressed ever since. I dread the thought of a surgeon messing with my eyes.

 

[GAF]

B2 riboflavin.

Not sure if its been mentioned. Known preventer of cataracts.

 

[daphne134]

I always hear good things about systemic enzymes but I was lucky to observe a side effect shortly after using a very good Serraptase brand Enerex. I used it for 1 day only, taking 3 x 120k strength capsules, but this was only after 2 months of taking ZymEssence.

While taking Zym my blood pressure increased, and I ignored it. When I tokl Serra my wbc and neutrophils jumped up above range.

My blood pressure never went down and it's been a year already. I suspect now that immune complexes were released as the plaque lysed and it deposited on my kidneys. And this is why I want to try urine therapy to clear out the immune complexes.

Please observe the effects of Serra on you as you start taking it. The enzyme makers keep telling us it's the best thing since sliced bread.

Ive had periodontitis and the result are immune complexes. Perhaps it is the result of vaccination changing my immune response to the periodontal bacteria that led to a strong antibody response that led to immune complexes that weren't cleared up by macrophages. But this is my context and you don't have this context. But just be observant.

But I'd rather have systemic enzymes as a last resort since you already have alternatives.

The strategy I'm settling on is based on serrapeptase and urea/urophagia. (Now I'm really wishing I'd been more into anonymity back when I started this account - ha!) Serrapeptase seems to hold the best hope of clearing the bad proteins in my crystalline lens. Urea seems to have the best hope of restoring the cell balance so the serrapeptase can get in there. Also going to give Can-C drops another try.
Also most days: one drop each A, D, K, and some E at night. Plus riboflavin, thiamine, nac, mag spray, iodine, ndt, progest-e, and will be adding some gluthione. Oj and milk (A2 when I can get it) throughout the day.
Bit of Lanosterol and/or Castor oil in the eye is soothing and has (I think ) been holding off the disease pattern while figuring out protocol. However will stop nightly use of those so the more targeted substance can (hopefully) get to the eyes. Also rereading Peat's urea stuff I think I have been overalkanizing eyes with too many baking soda (in distilled water) washes so I intend to cut the baking soda way back but continue distilled water washes.
Also looked a bit into acupressure and will stimulate the GB37 area regularly.
Since initial post my eyesight got better then worse as I've tried different things while developing a protocol (with your all's help - ty).
Not sure if/how aspirin figures into my etiology and will probably skip for now.
So far, serrapeptase makes me tired but deepens my breath.

 

[daphne134]

My eye dr said he could see the start of cataracts in my eyes at 49 years old, and I've been stressed and depressed ever since. I dread the thought of a surgeon messing with my eyes.

Sigh, yeah. It's so wrong that not a thought is given to other approaches.

 

[daphne134]

Just want to add to my protocol from yesterday, have decided to add a couple drops of IL's lanosterol in my daily distilled water eye bath. (And may be start eyebright washes as well.)

 

[Birdie]

Aspirin helps

N-acetylcarnosine drops

I used Can-C (N-acetylcarnosine) drops a few years back. I'd been dxd with early cataracts. After using the Can-C for 4 months, visiting an ophthamologist, I was told the first diagnosis must have been an error because the cataracts were not significant. I think it was forum member Mitter who recommended Can-C to me.

 

[Birdie]

I think it was 4 months. Could have been longer like 6 months. I used the drops twice a day.

 

[ecstatichamster]

I used Can-C (N-acetylcarnosine) drops a few years back. I'd been dxd with early cataracts. After using the Can-C for 4 months, visiting an ophthamologist, I was told the first diagnosis must have been an error because the cataracts were not significant. I think it was forum member Mitter who recommended Can-C to me.

great to hear it!

 

[daphne134]

great to hear it!

That is great!!
Unfortunately mine aren't at that stage. I'm basically blind in the left eye and it happened over the course of a month.
Since I first posted this I put together a timeframe (based on when I could and couldn't read a certain textbook) and I recalled a possible injury that triggered this. (Of the 2 doctors in the office one thought it had been triggered by some trauma.)
With that said I am using NAC drops now as part of my protocol.

 

[David PS]

Done.

I see that Ray has discussed this question cataracts as the last question in his recent interview with Jodelle in the thread
Ray Peat Interview - Get Fit With Jodelle - Iodine, Spider Veins, Oxalates, Fat Loss (July 31)

 

[David PS]

B2 riboflavin.

Not sure if its been mentioned. Known preventer of cataracts.

Just to buttress your statement, Adelle Davis wrote about B2 and cataracts in her books, You can find a link to one of her books in this thread Looking For Adelle Davis Books Online

At page 111 of the pdf ( page 97 of the printed book) is where the B2 -cataract info is located.

 

[daphne134]

Hello Kind People,
I wanted to update the thread since my directions have changed based on self experimentation and new information. Most significant is the new bottle Lanomax sent. I let the box sit unopened for maybe a week and opened it yesterday. The packaging was professional this time - shrink wrap around the top, good solid box, and wrapped in bubble wrap. Reason I opened the box after the initial experience had to do with a ton of research I have been doing. It's too much to go into right now but my research led to this being x-linked cataracts, that is, congenital (multifactorial with a genetic basis, triggered by various insults and injuries, some my own doing, some not).
I had been doing Can-C, and sodium bicarb + distilled eyewashes, along with trying to hone in on a nutritional strategy. Things were not getting better, vision worsening, hardening and discomfort in the area. My research into eye anatomy and physiology and trying to hone in on what my pathology actually is led me to think Lanomax is my best bet. (Though I have some of those Ethos Brighteyes (NAC) on order, and Oftan Chatoram.)
I have yet a lot of work to do on my genetic condition and reversing or mitigating the internal issues causing this. I'm setting aside the serrapeptase for now (though it did some good, I think). Rereading / listening to all Peat's cataract stuff is a next step in my journey as well as contacting specialists on my genetic condition (one of whom is an optometrist.)
Lanomax, doesn't sting at all, my eyes are hungry for it. Their faq explains their delivery platform gets past layers of impermeable tissue all the way to the back of the lens, permeating the lens for some time. It actually sounds like it's written by the team that did the original lanosterol research - because it is! And with proper packaging I'm more inclined to believe them. Ah ... and it's already improving my eyesight. It is very needed, and I wanted to get the word out. It's so hard to be a cataract patient and hear/see all the sunshiny talk of surgery, knowing that other possibilities aren't studied, and possible underlying conditions aren't discussed (except diabetes).

 

[ecstatichamster]

Very good news. Thank you

 

[daphne134]

Very good news. Thank you

Thank you! New update here.

 

[Tristan Loscha]

@daphne134

What is your diet like? Weight height, activity?

 

[daphne134]

@daphne134

What is your diet like? Weight height, activity?

I am 5"3' and around 120-ish pounds (don't weigh self regularly).

Currently diet consists of: Spelt bread (white) and sometimes noodles (ordered from Berlin Bakery). Butter, ghee. Coconut oil corn chips. Rice. Eggs (usually one per day). Cheese made with rennet when I can find it. OJ. A2 milk. Mexican Coke. Coffee with cream and palm sugar. Some lamb, chicken, beef, shrimp. Salads sometimes with non-pufa dressing. Potatoes. Tamales. Fruit. And a lot of supplements fairly regularly (A, D, K, E, riboflavin, thiamine, occasional iodine, occasional B-Complex, progest-E cyclically, NDT each morning again (stopped it, restarted.) Also added a spray from Natural Opthalmics recently. and sometimes gluthione which I've been going back and forth about in another post.

Anything jump out at you?

 

[Tristan Loscha]

-

 

[Tristan Loscha]

Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor
A Beyer-Mears, E Cruz
Diabetes 34 (1), 15-21, 1985
Aldose reductase is implicated in the pathogenesis of diabetic cataracts; therefore, inhibition of this enzyme subsequent to cataractogenesis may represent a therapeutic approach for restoration of lens physiology. In the present study, the effect of aldose reductase inhibition subsequent to stage I cataract formation was investigated in the streptozocin-induced diabetic rat. Our results indicated that the aldose reductase inhibitor sorbinil, a spirohydantoin, arrested further progression and promoted a reparative process despite continuation of hyperglycemia and elevated lens glucose. Quantitative analysis of scanning electron micrographs indicated that the afflicted lens regions were contained and their cellular components stabilized with regard to fiber hydration and interdigitation. The reparative process included: normalization of lens sorbitol, gradual recovery of existing fiber contour and interdigitation, production of new fibers, and partial restoration of lens myo-inositol content.





Diabetes mellitus is recognized as a leading cause of new cases of blindness, and is associated with increased risk for painful neuropathy, heart disease and kidney failure. Many theories have been advanced to explain mechanisms leading to diabetic complications, including stimulation of glucose metabolism by the polyol pathway. Additionally, the enzyme is located in the eye (cornea, retina, lens), kidney, and the myelin sheath–tissues that are often involved in diabetic complications.[14] Under normal glycemic conditions, only a small fraction of glucose is metabolized through the polyol pathway, as the majority is phosphorylated by hexokinase, and the resulting product, glucose-6-phosphate, is utilized as a substrate for glycolysis or pentose phosphate metabolism.[15][16] However, in response to the chronic hyperglycemia found in diabetics, glucose flux through the polyol pathway is significantly increased. Up to 33% of total glucose utilization in some tissues can be through the polyol pathway.[17] Glucose concentrations are often elevated in diabetics and aldose reductase has long been believed to be responsible for diabetic complications involving a number of organs. Many aldose reductase inhibitors have been developed as drug candidates but virtually all have failed although some such as epalrestat are commercially available in several countries. Additional reductase inhibitors such as ranirestat, ponalrestat, rinalrestat, risarestat, sorbinil, and berberine[18] are currently in clinical trials.[19]



Aldose reductase - Wikipedia


Nutritional modulation of cataract


The Association of Dietary Lutein plus Zeaxanthin and B Vitamins with Cataracts in the Age-Related Eye Disease Study: AREDS Report No. 37 - PubMed






"reductase inhibitors such as ranirestat, ponalrestat, rinalrestat, risarestat, sorbinil, and berberine[18] are currently in clinical trials." "Epalrestat" is available in Japan for this use case seemingly; maybe international Pharmacy?
Epalrestat - Wikipedia

maybe a Multi with high amounts of Bs, like Thorne Research 2/day, and a ketogenic diet? Bloodsugar is one measurement, but what about tissue concentrations and sensitivity. Either way, i do not know enough.

 

[daphne134]

Oh and broth powder (mostly type 2 collagen) from Perfect Supplements,