IGF1 : IGFBP3 Ratio As A Predictor Of Male Vertex Balding

[Sourdoughbanana]

I'll try to find a list I made a while ago of everything that increase IGFBP3.

That’d be awesome :)

Reading this topic I could focus on:
- supplementing mk677 again
- eat more yams
- eat less iron
- keep avoiding dairy
- keep eating lots of vitamin C

 

[Elephanto]

@Sourdoughbanana

Here are things that both increase Nitric Oxide and decrease IGFBP3 : Arginine, Estrogen, Endotoxins, Iron, Arachidonic Acid, Vitamin D deficiency, Ammonia, lack of Magnesium, Vitamin A, Zinc.

 

[Sourdoughbanana]

@Sourdoughbanana

Great. Just found this:

https://www.physiology.org/doi/full/10.1152/ajpendo.00451.2005

DHT and T each increased IGF-I (7-fold) and decreased IGFBP-3 (2-fold) mRNA expression and protein secretion in a dose- and time-dependent manner and increased IGFBP-2 (2-fold) mRNA in a dose- and time-dependent manner. DHEA and E2 did not significantly alter these measures.

 

[GorillaHead]

Great. Just found this:

https://www.physiology.org/doi/full/10.1152/ajpendo.00451.2005

Shouldnt u avoid mk cause that increases igf-1? This info is very enlightning. I know igf in the scalp is good for hair. Can be stinulated by massaging or wounding but serum is def bad.

 

[GorillaHead]

Great. Just found this:

https://www.physiology.org/doi/full/10.1152/ajpendo.00451.2005

Wonder what 7 grams of vitamin c will do to u

 

[Sourdoughbanana]

Mk677 would increase GH within physiological range, which shall increase both igf1 and igfbp3

As per the OP

 

[guapeat]

Estrogen also directly increases IGF-1. That's why human trials with high-dose DHEA (which is VERY estrogenic) found much higher IGF-1 levels post-supplementation.

This is confusing though because in the past estrogen has been used (and still sometimes) to antagonize GH when treating acromegaly. How does this works?

 

[TheBeastPanda]

Estrogen also directly increases IGF-1. That's why human trials with high-dose DHEA (which is VERY estrogenic) found much higher IGF-1 levels post-supplementation.

Hello Haidut, i've been following your content for years and finally decided to join this wonderful forum, one of the first questions of many haha

Thoughts on the links between aromasin and prolactin?

 

[ddjd]

Hello Haidut, i've been following your content for years and finally decided to join this wonderful forum, one of the first questions of many haha

Thoughts on the links between aromasin and prolactin?

aromasin as in the drug exemestane ?

 

[TheBeastPanda]

aromasin as in the drug exemestane ?

yes bro

 

[ddjd]

yes bro

what does it raise prolactin? or lower it?