Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3. - PubMed - NCBI
Useful things to take from this + additional informations :
Milk contains IGF-1 but no IGFBP3, thus increasing the ratio of IGF1:IGFBP3 that is predictor of vertex balding.
Growth hormone increases IGF1 and IGFBP3 proportionally. IGFBP3 is a growth hormone-responsive gene.
IGFBP3 restricts growth excess (skull/collagen growth leading to blood constriction and calcification in male balding), and is low in many types of cancer like prostate cancer.
Estrogen and iron reduce IGFBP3.
Of the 431 men, 128 had vertex balding at age 45. Compared with men who were not balding, for a 1 standard deviation increase in plasma IGF-1 level (72.4 ng/mL), the OR for vertex balding was 1. 31 (95% CI, 0.95-1.81).
For a 1 standard deviation increase in plasma IGFBP-3 (957 ng/mL), the OR for vertex balding was 0.62 (95% CI, 0.44-0.88).
Useful things to take from this + additional informations :
Milk contains IGF-1 but no IGFBP3, thus increasing the ratio of IGF1:IGFBP3 that is predictor of vertex balding.
Growth hormone increases IGF1 and IGFBP3 proportionally. IGFBP3 is a growth hormone-responsive gene.
IGFBP3 restricts growth excess (skull/collagen growth leading to blood constriction and calcification in male balding), and is low in many types of cancer like prostate cancer.
Estrogen and iron reduce IGFBP3.