If estrogen is a paracrine hormone, how do we lower it?

Alexanders

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I know that Aromatase Inhibitors (AI) lower estrogen in serum, but how do we lower the overall estrogenic activity if estrogen is a paracrine hormone?
 
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What does 29pg/ml E2 and 532ng/dl for a man mean
See if your answer is here…

 
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“Thyroid, progesterone, and testosterone are among the most effective natural antiestrogens” -Ray Peat
 
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