paymanz said:haidut said:Nobody knows for sure, but hypothyroidism in younger people is one known cause. Older people have this issue all the time and this is why they don't react as well to protein supplementation as younger people. One "solution" is to increase protein intake but this way you are also increasing waste products like ammonia since it is not utilized very well. Low hormones levels are certainly part of it, including low T3, which is a prime factor in increasing protein synthesis. Gbolduev seem to think it is due to poor pancreas function, low gastrin, mineral deficiencies, etc. Peat kind of agrees but says these issues themselves are due to a deeper cause - low energy production.
haidut can you explain a little bit about "peripheral protein" please, i searched but didnt get it well... what are them??
By peripheral protein synthesis I mean muscle synthesis. The organs, including the brain, have amino acids requirements and some of the ingested aminos go towards that requirement. The rest of the protein should ideally go to build muscle and not to be oxidized as fuel. However, in older of hypothyroid people this does not happen very well and instead the protein is turned into glucose through deamination and gluconeogenesis and burned as glucose. This is very inefficient and also creates a lot of waste such as ammonia.