ICU Sepsis — help!

[healthiswellth]

My family is in icu for sepsis - they keep checking for infection / recurrent cancer as the cause -with no success— everything returning negative. I believe it is metabolic in origin. What specific tests can I ask for to check for metabolic dysfunction?

 

[Dolomite]

They usually use Lactic Acid values to help determine sepsis even if there are no positive bacterial cultures. Often blood cultures are collected but do not grow anything because the actual organism isn't in high enough quantities in the blood collected or the blood draws volumes were not sufficient. Did the person receive any of the so called vaccines? We had a friend who succumbed to "multi-system infection" per the hospital treating her several months after her shots.

 

[healthiswellth]

They usually use Lactic Acid values to help determine sepsis even if there are no positive bacterial cultures. Often blood cultures are collected but do not grow anything because the actual organism isn't in high enough quantities in the blood collected or the blood draws volumes were not sufficient. Did the person receive any of the so called vaccines? We had a friend who succumbed to "multi-system infection" per the hospital treating her several months after her shots.

Lactic acid/ Procalcitonin is High. Thank you for the insight— they always give it a 7-10 days to grow and haven’t seen anything. It didn’t occur to me that there wouldn’t be enough organism in the sample.
No vax.
He keeps getting hospitalized for this, but no one has determined the cause yet. I was wondering what tests would show mitochondrial dysfunction or a problem with glucose metabolism where excess lactate would be produced instead of oxidative phosphorylation/ Co2 production. Another member mentioned ceruloplasmin/serum copper so we have asked for that so far.
He’s also retaining co2 per abg results, so he is intubated.

 

[aliml]

I believe it is metabolic in origin. What specific tests can I ask for to check for metabolic dysfunction?

Pyruvate dehydrogenase complex deficiency (PDCD)!

The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy

Anaerobic glycolysis is the process by which glucose is broken down into pyruvate and lactate and is the primary metabolic pathway in sepsis. The pyruvate dehydrogenase complex (PDHC) is a multienzyme complex that serves as a critical hub in energy metabolism. ...

www.ncbi.nlm.nih.gov

 

[Lurker]

Perhaps aspirin could help.

Aspirin As A Cure For Sepsis

If the truly wonder-drug properties of aspirin were considered lacking by some medical authorities, now we can add curing sepsis to that list. Sepsis is the leading cause of death in hospitalized patients, regardless of age, condition, treatment, etc. It is largely considered a lost cause once...

raypeatforum.com

 

[LeeLemonoil]

Pyruvate dehydrogenase complex deficiency (PDCD)!

The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy

Anaerobic glycolysis is the process by which glucose is broken down into pyruvate and lactate and is the primary metabolic pathway in sepsis. The pyruvate dehydrogenase complex (PDHC) is a multienzyme complex that serves as a critical hub in energy metabolism. ...

www.ncbi.nlm.nih.gov

Definitely to be considered especially when it is recurring regularly.

@aliml good call

From the publication:

. A group of drugs that target PDHC activation, including dichloroacetate (DCA), thiamine, amrinone, ciprofloxacin, and TNF-binding protein (TNFbp), have been shown to ameliorate the symptoms of sepsis

 

[Korven]

Vitamin C and Thiamine for Sepsis and Septic Shock - PubMed

Although no significant mortality benefit was observed, the vitamin C protocol was not associated with patient harm. In this Veteran population, there was reduced ICU length of stay, suggesting possible benefit. Though further investigation is warranted, utilization of IV vitamin C, thiamine...

pubmed.ncbi.nlm.nih.gov

IV vitamin C and thiamine could be something to consider.

 

[Rinse & rePeat]

“Sepsis is the body’s overwhelming and life-threatening response to infection that can lead to tissue damage, organ failure, and death. In other words, it’s your body’s overactive and toxic response to an infection. Like strokes or heart attacks, sepsis is a medical emergency that requires rapid diagnosis and treatment. Sepsis can lead to severe sepsis and septic shock.

You may have heard the term “blood poisoning” used instead of sepsis. Blood poisoning is not an accurate description of sepsis. You can learn more about sepsis and blood poisoning here.

Your immune system usually works to fight any germs (bacteria, viruses, fungi, or parasites) to prevent infection. If an infection does occur, your immune system will try to fight it, although you may need help with medication such as antibiotics, antivirals, antifungals, and antiparasitics. However, for reasons researchers don’t understand, sometimes the immune system stops fighting the “invaders,” and begins to turn on itself. This is the start of sepsis.

Some people are at higher risk of developing sepsis because they are at higher risk of contracting an infection. These include the very young (infants), the very old, those with chronic illnesses, and those with a weakened or impaired immune system.”

What Is Sepsis

Sepsis and septic shock is the body’s overwhelming and life-threatening response to infection that can lead to death.

www.sepsis.org

 

[ecstatichamster]

My husband died from sepsis 6 weeks ago. His was bacterial.

IS THIS THE REAL CAUSE OF COVID DEATHS C. DIFF INFECTIONS?

I have been reading about Clostridium Difficile because my husband has been diagnosed with it today. It is a "super bug" bacterial infection with a high mortality rate. The doctor said he got it from his last hospital visit for a spinal compression fracture. This is some scary stuff, but it is...

raypeatforum.com

I’m so very sorry.

 

[JudiBlueHen]

My husband died from sepsis 6 weeks ago. His was bacterial.

IS THIS THE REAL CAUSE OF COVID DEATHS C. DIFF INFECTIONS?

I have been reading about Clostridium Difficile because my husband has been diagnosed with it today. It is a "super bug" bacterial infection with a high mortality rate. The doctor said he got it from his last hospital visit for a spinal compression fracture. This is some scary stuff, but it is...

raypeatforum.com

Oh my goodness - I am so sorry to hear that. Prayers for you and your family. I always enjoy your posts.

 

[Rinse & rePeat]

I’m so very sorry.

Thank you.

 

[Rinse & rePeat]

…

My family is in icu for sepsis - they keep checking for infection / recurrent cancer as the cause -with no success— everything returning negative. I believe it is metabolic in origin. What specific tests can I ask for to check for metabolic dysfunction?

I just rememberd it was your father dealing with stuff a month ago! Is it he who sepsis?

 

[-Luke-]

@Rinse & rePeat: I'm sorry to hear that. I wish you and your family a lot of strength.

 

[Rinse & rePeat]

@Rinse & rePeat: I'm sorry to hear that. I wish you and your family a lot of strength.

Thank you Luke.

 

[Rinse & rePeat]

Oh my goodness - I am so sorry to hear that. Prayers for you and your family. I always enjoy your posts.

Aww thank you Judi :)

 

[Rinse & rePeat]

“For medical professionals​

• Sepsis treatment protocol​

  Vitamin C: 1.5 g IV q 6 hourly for 4 days or until discharge from the ICU.
  Hydrocortisone: 50mg IV q 6 hourly for 4 days or until discharge from the ICU. Taper is not required.
  Thiamine: 200mg IV q 12 hourly for 4 days or until discharge from the ICU. Alternative dosing: 100mg IV q 6 hourly for 4 days.
  

  Read the entire Marik sepsis protocol”​

A cure for sepsis? | EVMS Magazine 9.4

 

[3apples555]

@Rinse & rePeat: I just now read your other post, I am SO sorry for your loss. You contribute so much to everyone's experience via this forum, I have learned so much from you and cherish your recipes. My deepest condolences and stay strong. ♥

 

[Rinse & rePeat]

@Rinse & rePeat: I just now read your other post, I am SO sorry for your loss. You contribute so much to everyone's experience via this forum, I have learned so much from you and cherish your recipes. My deepest condolences and stay strong. ♥

Thank you Apples, I am doing alright :)

 

[LeeLemonoil]

“For medical professionals​

• Sepsis treatment protocol​

  Vitamin C: 1.5 g IV q 6 hourly for 4 days or until discharge from the ICU.
  Hydrocortisone: 50mg IV q 6 hourly for 4 days or until discharge from the ICU. Taper is not required.
  Thiamine: 200mg IV q 12 hourly for 4 days or until discharge from the ICU. Alternative dosing: 100mg IV q 6 hourly for 4 days.
  

  Read the entire Marik sepsis protocol”​

A cure for sepsis? | EVMS Magazine 9.4

This protocols success hasn’t been replicated unfortunately despite many practitioners giving it a try.

Also, OP knows what Sepsis is but he might be confronted with a non-microbiologicaly caused phenomenon that shares mechanisms with sepsis but really isn’t. But a sort of lactate-poisoning because of impaired enzyme-complexes

 

[Dolomite]

If the person's immune system isn't as good as it should be and depending on the type and location of the cancer there may be osteomyelitis or something like a slow leak into the blood stream. Does the person complain of pain in a specific location? That is often the source even if it can't be seen on x-rays, etc.