I Am Addicted To Metformin

[Lokzo]

So many of you probably already know who I am, but for those who don't, I am that guy who maxed his Testosterone naturally:

You can check my thread on it here:
I Made My Testosterone Off The Scale High - Men's Health

Anyway, getting to the point of this post.

I started taking metformin after (ab)using Cyproheptadine for many months.

I first started dosing at 500mg XR form, usually with my biggest carb meal in the evenings.

I didn't really notice much at the start, apart from slightly reduced appetite.

2 weeks later these are the key effects I had noticed from
regularly taking 250mg-500mg of XR Metformin whilst on a high carb diet:
-INSANE muscle pumps, to the point of almost feeling like veins were gonna pop.
-Improved gym performance.
-Leaner physique.
-Reduced appetite.
-Better cortisol awakening response (Did you know that metformin can do what licorice does with cortisol?)
-Easier to fast if I had to.

Obviously I am aware of the side effects of metformin use:
-B12 Deficiency (Currently supplementing to offset)
-Homocysteine issues (Taurine to offset)
-Raises cortisol (I need this).

But what makes me feel "Addicted to it"


THE PUMPS!!!

No other GDA has come close. If anyone has any other natural botanical or any other compound that can match this I will be impressed.


Cheers.

 

[PleaseDoo21]

doesn't metformin hold slightly anti-androgenic activity? correct me if I'm wrong.

 

[Lokzo]

doesn't metformin hold slightly anti-androgenic activity? correct me if I'm wrong.

It certainly does, at ridiculously high doses, and it doesn't bother me in the slightest with such high natural Testosterone.

I believe it also inhibits aromatase:
Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. - PubMed - NCBI

 

[methylenewhite]

Test your serum lactate regularly.

 

[Vinny]

So many of you probably already know who I am, but for those who don't, I am that guy who maxed his Testosterone naturally:
View attachment 17694

You can check my thread on it here:
I Made My Testosterone Off The Scale High - Men's Health

Anyway, getting to the point of this post.

I started taking metformin after (ab)using Cyproheptadine for many months.

I first started dosing at 500mg XR form, usually with my biggest carb meal in the evenings.

I didn't really notice much at the start, apart from slightly reduced appetite.

2 weeks later these are the key effects I had noticed from
regularly taking 250mg-500mg of XR Metformin whilst on a high carb diet:
-INSANE muscle pumps, to the point of almost feeling like veins were gonna pop.
-Improved gym performance.
-Leaner physique.
-Reduced appetite.
-Better cortisol awakening response (Did you know that metformin can do what licorice does with cortisol?)
-Easier to fast if I had to.
View attachment 17696


Obviously I am aware of the side effects of metformin use:
-B12 Deficiency (Currently supplementing to offset)
-Homocysteine issues (Taurine to offset)
-Raises cortisol (I need this).

But what makes me feel "Addicted to it"


THE PUMPS!!!

No other GDA has come close. If anyone has any other natural botanical or any other compound that can match this I will be impressed.


Cheers.

Very interesting, thanks for sharing and for the photo as well. You look great.
I,ve got some Met in my cabinet. When I ordered it, tho, I was still eating carbs. Now I,m on a very low carb/high meat plan, and there is probably not much sense to try the stuff now.

 

[lvysaur]

-Leaner physique.
-Reduced appetite.

Do you still eat the same amount despite a reduced appetite?

 

[PleaseDoo21]

It certainly does, at ridiculously high doses, and it doesn't bother me in the slightest with such high natural Testosterone.

I believe it also inhibits aromatase:
Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. - PubMed - NCBI

I've heard at the standard therapeutic dosage of 500-1500mg it negatively affects androgen receptors via the inhibition of certain pathway functions, it can be used to treat prostate cancer in combination with an anti-androgen like flutamide or hydroxyflutamide. I'm sure you're fine though, it probably doesn't make a BIG difference, still good to know though.

Evidence has shown that MF has multiple antineoplastic effects through AMPK-dependent and independent mechanisms, the alteration of IGF-1 signaling pathways, suppression of the androgen receptor pathway, inhibition of the mTOR pathway, and lipogenesis. Conduction of meta-analysis suggests mortality benefit to patients who exhibit PCa when taking MF. Clinical trials have shown evidence, demonstrating MF to improving significantly.

Metformin represses prostate cancer cell viability and enhances apoptosis by targeting the AR signaling pathway. Combinations of metformin and other anti-AR agents pose a potentially promising therapeutic approach for the treatment of prostate cancers, especially the castrate-resistant prostate cancer, with high efficacy and low toxicity.

 

[Lokzo]

Test your serum lactate regularly.

Even at such low doses? Isn't that only an issue for those with compromised kidney function?

 

[Lokzo]

Do you still eat the same amount despite a reduced appetite?

I've been trying to eat around the same amount of carbs, but my training has also fluctuated significantly too. Some days I have been doing sprints in the morning and then weights in the afternoon... I'm getting obsessed with training atm lol.

 

[Lokzo]

Very interesting, thanks for sharing and for the photo as well. You look great.
I,ve got some Met in my cabinet. When I ordered it, tho, I was still eating carbs. Now I,m on a very low carb/high meat plan, and there is probably not much sense to try the stuff now.

Haha thanks Vinny!

I would be interested to see how you go if you do try it down the track... leave a comment back on this thread if you do!

 

[Vinny]

Haha thanks Vinny!

I would be interested to see how you go if you do try it down the track... leave a comment back on this thread if you do!

Ok!

 

[Callum1701]

Sounds like I need to give it a try. Do you have an Aussie vendor ?

 

[Lokzo]

Sounds like I need to give it a try. Do you have an Aussie vendor ?

My father is a pharmacist haha.

But I also have some coming from ALLDAYCHEMIST.

 

[Callum1701]

My father is a pharmacist haha.

But I also have some coming from ALLDAYCHEMIST.

well that helps ahaha

I’ll have a look, cheers dude

 

[Lokzo]

well that helps ahaha

I’ll have a look, cheers dude

Respond back here if you end up trying it out!

 

[Braveheart]

Research... Metformin Tumeric

 

[Lokzo]

Research... Metformin Tumeric

There are plenty of studies... Which one specifically?

 

[danishispsychic]

wow , super ripped and muscle -y. i take 500 mg metformin a day and really like it . i have taken it for a while and i like how it improves my mood and sleep. i drink red bull yellow each day and do some b12 here and there . i get my metformin on " anti aging systems " website . they are reliable :)

 

[A.R]

Hmm I don't know
Haidut posted a study of it being toxic somewhere on here

 

[brix]

wow , super ripped and muscle -y. i take 500 mg metformin a day and really like it . i have taken it for a while and i like how it improves my mood and sleep. i drink red bull yellow each day and do some b12 here and there . i get my metformin on " anti aging systems " website . they are reliable :)

why did you start taking it?