How To Make Reward System Very Sensitive?

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40mg was used in the study. You replay the thing you are trying to get past. Then you sleep.

That’s it.
 
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GorillaHead

GorillaHead

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Damn 25 bucks for 5 pills. Drug dealer prices lol on for hims. Do you have anything that shows it has an affect on the reward system. I guess using it one time couldn’t hurt.
 
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No I only see evidence for it reprogramming bad memories. But it could work for your purpose too.

It should be ultra cheap.
 

Tarmander

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Long term from drug use: suffering

short term from too much stimulation: boredom
 
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GorillaHead

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No I only see evidence for it reprogramming bad memories. But it could work for your purpose too.

It should be ultra cheap.


I will let you know how it goes. Funny enough I was going to order it for 25 bucks for 5 pills but I didn’t. Then an hour later I get an email offering some a 15 dollar discount to finish checking out my cart.


10 bucks for 5 pills. Not bad
 

Sativa

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How can one reset the reward system in the mind so it is sensitive to even the smallest accomplishments? Any supplements that can help with this process.
I made a post in this thread that lists/describes the exact substances and strategies to accomplish this. see my profile posting history or look in the 1st/2nd page here:
Jordan Peterson In Rehab

also, Agmatine would be a good pharmacological approach, as it possesses ideal properties which help restart/reset brain pathways, similarly to the 'Gold standard' - iboga. The synthetic gold standard equivalent would be memantine, ketamine (v low dose btw).

A most suitable & ideal pharmacological approach would target the multiple key areas in unison.
 
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GorillaHead

GorillaHead

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I made a post in this thread that lists/describes the exact substances and strategies to accomplish this. see my profile posting history or look in the 1st/2nd page here:
Jordan Peterson In Rehab

also, Agmatine would be a good pharmacological approach, as it possesses ideal properties which help restart/reset brain pathways, similarly to the 'Gold standard' - iboga. The synthetic gold standard equivalent would be memantine, ketamine (v low dose btw).

A most suitable & ideal pharmacological approach would target the multiple key areas in unison.

i have memantine U sure that it will reset things?
 

Sativa

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i have memantine U sure that it will reset things?
I started initially with a low dose, since it was my first time, and I'd done enough research to familiarise myself with the potential for a psychoactive experience at higher doses. I had 5mg sublingually (crushed the pill), then gauged how my brain chemistry had been influence, opting to take another 5mg, sublingually at least 2 months later.

memantine is also an ideal solution/aid for tobacco cessation, but the herb Lobelia inflata is more ideal, and 'time tested'.
 

Sativa

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Also, lowering PROLACTIN would be a good way to boost dopamine.
eg Vitamin E, B6, Coffee (by potentiating dopamine 'receptor' function), possibly chaste berry - via Dopamine receptor activation (but it might affect other areas inc pituitary, FSH & LH - progesterone, Dopamine D2 'receptor')
More on chasteberry:
Endometriosis
The Clinician's Handbook of Natural Medicine (Third Edition), 2016
Vitex agnus-castus (chaste tree): treats hormone imbalances in women, acting on the pituitary to increase luteinizing hormone, which stimulates progesterone production.
Uses: reducing estrogen excess linked to fibroids, premenstrual syndrome, perimenopause, symptoms of endometriosis
Chaste tree (chasteberry) is very popular in Europe in treating PMS and was considered to be the best herb in maintaining emotional balance before and during menses, as well as in menopause.
Some consider it as a “natural replacement alternative for estrogen replacement therapy”.
The lay press has suggested its use for menopause symptoms such as hot flushes, and it is said to stimulate pituitary function, alter LH and FSH secretions, and increase natural levels of progesterone.
This herb may inhibit secretion of prolactin by the pituitary gland

Uridine Monophosphate
YES, that's a brilliant one for Dopamine upregulation & re-balancing.
From what i can remember, due to interactions in common areas, don't combine high doses of Uridine with tobacco / caffeine.
Uridine amplifies the effect of these stimulants and others, including methamphetamines. It could be helpful in reducing dependence on these stimulants.
 
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Sativa

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Here's a more indepth insight into Uridine, there's some Peaty properties to be had here!
(source GPC (choline), Uridine, DHA - Brain Health - LONGECITY)
> Cellular growth / health and replication
> Mitochondrial efficiency
Secretion of ATP from Schwann cells in response to uridine triphosphate. - PubMed - NCBI
Secretion of ATP from Schwann cells in response to uridine triphosphate.
> Uridine receptor; Sleep / sleeping patterns
Uridine receptor: discovery and its involvement in sleep mechanism. - PubMed - NCBI
Uridine receptor: discovery and its involvement in sleep mechanism.
Learning and memory, Synaptogenesis, Neurogenesis
Myelination
Increasing free phosphatidylcholine
Increasing receptor densities
Improving lipid membrane health
Uridine promotes cellular growth and DNA repair. By virtue of this, it can accelerate the effects of a folate (Vitamin B9) deficiency.
Folate deficiency can lead to DNA transcription errors, strand breakage and carcinogenesis. Conversely, too much folate can also cause the same issues.
Obtaining the RDA for B group vitamins from food or supplements should be part of any normal daily regimen, but if you are going to take uridine, it is a suggested requirement to take a multi-B vitamin with it, regardless of your diet.
Benefits reported for -
> Modulating / normalising dopamine release
> Uplifting and stabilising mood
> Stress, OCD, Anxiety

http://cat.inist.fr/...cpsidt=17035532
Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats

http://ebm.rsmjourna...4/1/49.abstract
Chronic uridine modulates the stimulant-induced release of dopamine

Effects of chronic treatment with uridine on striatal dopamine release and dopamine related behaviours in the absence or the presence of chronic trea... - PubMed - NCBI
Effects of chronic treatment with uridine on striatal dopamine release and dopamine related behaviours in the absence or the presence of chronic treatment with haloperidol.

Uridine reduces rotation induced by l-Dopa and methamphetamine in 6-OHDA-treated rats - ScienceDirect
Uridine reduces rotation induced by l-Dopa and methamphetamine in 6-OHDA-treated rats
 
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sebastian_r

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Step 1: Dopamin fasting - No social media, no forums, no smartphone, no porn / masturbation, no TV (I recommend to get rid of one at the time, get used to it, then tackle the next one 1-2 weeks later)
Step 2: Connect the rewards of the day that are left in your life with your goals. E.g. breakfast only after 2 hours of work on your goals. Lunch only after additionally 4 hours of work. Walk in the sun only after all goals of the day are achieved. Another tip would be to use an additional pleasent sound after accomplishing your task and before you reward yourself for accomplishing your goal.
Step 3: Track everything in a spreadsheet with green and red colours and make a game out of achieving your daily goals.

Sience / lgoic behind it:
Video one: Dailymotion Video Player - Dopamine Jackpot! Sapolsky on the Science of Pleasure
Video two:
 
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milkboi

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The Modulation of Dopamine Receptor Sensitivity by Thyroid Hormones: A Behavioural and Neurochemical Investigation

I'm wondering if Thyroid has a more powerful effect than a lot of the things listed in the thread.

You can do a quick google search for the top 50 things that increase dopamine, but which ones are the most impactful?

I think it might be Thyroid.

Time to start an TyroMax NDT experiment to test the theory...

very interesting, let us know how it goes
 

lampofred

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RP wrote that DHA, arachidonic acid, and intracellular calcium excess from PUFA accumulation lower sensitivity to stimuli. Exposure to CO2 from increased thyroid, vitamin D, and maybe mechanical means like bag breathing restores sensitivity.
 

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