How to lower ACTH and HPA AXIS(Cushings disease)

[Barbarossa]

Hey guys,

I have High ACTH LEVELS(sometimes I get high cortisol levels too) for over 7 years now. Two doctors confirmed a micro Adenoma on the right side of the pituitary gland. My health situation is worsening from year to year.

I take thyroid, Cyproheptadine(i know it can treat Cushings disease), LORAZEPAM (high anxiety impending doom situations) it brings my Acth down I can feel it very well, propranolol against high heart rate.

What can I take to bring down ACTH for longterm ?

 

[tastyfood]

Hey guys,

I have High ACTH LEVELS(sometimes I get high cortisol levels too) for over 7 years now. Two doctors confirmed a micro Adenoma on the right side of the pituitary gland. My health situation is worsening from year to year.

I take thyroid, Cyproheptadine(i know it can treat Cushings disease), LORAZEPAM (high anxiety impending doom situations) it brings my Acth down I can feel it very well, propranolol against high heart rate.

What can I take to bring down ACTH for longterm ?

Did you get an MRI to confirm the adenoma?

How high is your ACTH if you don't mind me asking? Mine is always over the range. Once, it was 99!

How's your cortisol, prolactin, LH, FSH?

Note from another thread in the forum:

Magnesium, vitamin B1, Pyrucet, aspirin, progesterone and niacinamide
Pregnenolone is known to lower the release of ACTH

 

[haidut]

Hey guys,

I have High ACTH LEVELS(sometimes I get high cortisol levels too) for over 7 years now. Two doctors confirmed a micro Adenoma on the right side of the pituitary gland. My health situation is worsening from year to year.

I take thyroid, Cyproheptadine(i know it can treat Cushings disease), LORAZEPAM (high anxiety impending doom situations) it brings my Acth down I can feel it very well, propranolol against high heart rate.

What can I take to bring down ACTH for longterm ?

Anabolic/androgenic steroids are known to suppress the adrenals and the pituitary. So, if the situation becomes out of control then I'd ask the doctor about it (if you are a male). Cyproheptadine, when taken for a prolonged period of time, should be able to actually cure it and make the adenoma disappear. It may reappear if you are under stress, but then you can start using it again and for many people eventually the adenoma disappears for good. That's why cyproheptadine is the main drug used to cure Cushing syndrome/disease in race-horses, who often get it due to the extreme stress from racing. The first study below claims that another anti-serotonin called pergolide worked better than cyproheptadine, but when used by itself it is not very safe due to risk if fibrosis and if used then it may be a good idea to combine with cyproheptadine as the latter protects from the fibrotic risks of the former.

Treatment with pergolide or cyproheptadine of pituitary pars intermedia dysfunction (equine Cushing's disease) - PubMed

Medical records of 27 horses (including 13 ponies) treated with pergolide or cyproheptadine for pituitary pars intermedia dysfunction were reviewed to determine the effect of treatment on plasma ACTH, insulin, and glucose concentrations and clinical signs. Prior to treatment, the most common...

pubmed.ncbi.nlm.nih.gov

https://journals.physiology.org/doi/full/10.1152/ajpheart.01177.2008

https://www.jneurosci.org/content/jneuro/16/5/1866.full.pdf

Testosterone Suppression of CRH-stimulated Cortisol in Men

Despite observations of age-dependent sexual dimorphisms in hypothalamic-pituitary-adrenal (HPA) axis activity, the role of androgens in the regulation of HPA axis activity in men has not been examined. We assessed this role by performing CRH stimulation ...

www.ncbi.nlm.nih.gov

 

[Jessie]

Have you tried progesterone? Progesterone mixed with a little DHEA seems to be the most effective anti-cortisol treatment for me.

 

[Barbarossa]

Anabolic/androgenic steroids are known to suppress the adrenals and the pituitary. So, if the situation becomes out of control then I'd ask the doctor about it (if you are a male). Cyproheptadine, when taken for a prolonged period of time, should be able to actually cure it and make the adenoma disappear. It may reappear if you are under stress, but then you can start using it again and for many people eventually the adenoma disappears for good. That's why cyproheptadine is the main drug used to cure Cushing syndrome/disease in race-horses, who often get it due to the extreme stress from racing. The first study below claims that another anti-serotonin called pergolide worked better than cyproheptadine, but when used by itself it is not very safe due to risk if fibrosis and if used then it may be a good idea to combine with cyproheptadine as the latter protects from the fibrotic risks of the former.

Treatment with pergolide or cyproheptadine of pituitary pars intermedia dysfunction (equine Cushing's disease) - PubMed

Medical records of 27 horses (including 13 ponies) treated with pergolide or cyproheptadine for pituitary pars intermedia dysfunction were reviewed to determine the effect of treatment on plasma ACTH, insulin, and glucose concentrations and clinical signs. Prior to treatment, the most common...

pubmed.ncbi.nlm.nih.gov

https://journals.physiology.org/doi/full/10.1152/ajpheart.01177.2008

https://www.jneurosci.org/content/jneuro/16/5/1866.full.pdf

Testosterone Suppression of CRH-stimulated Cortisol in Men

Despite observations of age-dependent sexual dimorphisms in hypothalamic-pituitary-adrenal (HPA) axis activity, the role of androgens in the regulation of HPA axis activity in men has not been examined. We assessed this role by performing CRH stimulation ...

www.ncbi.nlm.nih.gov

Thank you Haidut!
I am male 29 years old ,86 kg , 174 cm big. How much Cyproheptadine is safe? Whats best dosage for Cushings Disease ? And how long could I take it to feel better?

I take cypro in 0,5 mg x3 times a day. That’s too low isn’t it?

 

[haidut]

Thank you Haidut!
I am male 29 years old ,86 kg , 174 cm big. How much Cyproheptadine is safe? Whats best dosage for Cushings Disease ? And how long could I take it to feel better?

I take cypro in 0,5 mg x3 times a day. That’s too low isn’t it?

All of this information can be easily found by Googling around. When you ask somebody such questions, especially about doses and specific diseases, you are asking them to give "unlicensed medical advice".

 

[TammyFR]

Hey guys,

I have High ACTH LEVELS(sometimes I get high cortisol levels too) for over 7 years now. Two doctors confirmed a micro Adenoma on the right side of the pituitary gland. My health situation is worsening from year to year.

I take thyroid, Cyproheptadine(i know it can treat Cushings disease), LORAZEPAM (high anxiety impending doom situations) it brings my Acth down I can feel it very well, propranolol against high heart rate.

What can I take to bring down ACTH for longterm ?

Cyproheptadine Monograph for Professionals - Drugs.com

Cyproheptadine reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI).

www.drugs.com

Here is some information on Cypro and Cushings