How to get out of a hyper-serotonergic state (gut focused)

bluefish

Member
Joined
Jan 2, 2019
Messages
246
If I’m not mistaken, cyproheptadine works good also as a supplement. I use it to lower serotonin
 

golder

Member
Joined
May 10, 2018
Messages
2,851
Does ondansetron lower seratonin more or less than cyproheptadine? Thanks!
 
OP
Hans

Hans

Member
Forum Supporter
Joined
Aug 24, 2017
Messages
5,856
Does ondansetron lower seratonin more or less than cyproheptadine? Thanks!
Its common/main mechanism is via 5-HT3 antagonist, whereas serotonin antagonizes a lot of other serotonin receptors as well. On the other hand, I haven't seen evidence that cypro is also a 5-HT3 antagonist.
 

golder

Member
Joined
May 10, 2018
Messages
2,851
Its common/main mechanism is via 5-HT3 antagonist, whereas serotonin antagonizes a lot of other serotonin receptors as well. On the other hand, I haven't seen evidence that cypro is also a 5-HT3 antagonist.
In your option what would be the most comprehensive way of antagonising all seratonin receptors with the least side effects?
 

Sam321

Member
Joined
Jan 27, 2021
Messages
652
I know this is primarily focused on the gut and I think it is worth the effort for sure.
But I really think more than anything else, having new positive experience do more than nearly anything in reducing learned helplessness.
I'm saying this after having to dig myself out of that state over the past half year and having tired most gut protocols. Everything in my body works better and smoother when I am having fun with my friends, not in isolation with all the bad things that have happened to me throughout my life.

Godspeed!
 
OP
Hans

Hans

Member
Forum Supporter
Joined
Aug 24, 2017
Messages
5,856
I know this is primarily focused on the gut and I think it is worth the effort for sure.
But I really think more than anything else, having new positive experience do more than nearly anything in reducing learned helplessness.
I'm saying this after having to dig myself out of that state over the past half year and having tired most gut protocols. Everything in my body works better and smoother when I am having fun with my friends, not in isolation with all the bad things that have happened to me throughout my life.

Godspeed!
For sure haha. Isolation is stressful, which in turn has a negative effect on the gut and almost everything else.
 

Similar threads

Back
Top Bottom