This is very interesting. Do you take 500mg four times throughout the day? 1g morning and 1g evening? Is there anything to be cautious of when dosing so high? Is it wise to take anything else alongside the B1 i case it gets depleted? Thanks!I've had a history of low stomach acid for at least 25 years. I am much improved since taking high dose thiamine. I am taking 2 grams of thiamine hcl/day now and can digest meat again. You might consider learning more about thiamine supplementation if you are having digestive issues.