How To Boost Dopamine Receptors

[Mauritio]

N

Not sure why I didn't include the study there. Here it is: The effects of scopolamine and the nootropic drug phenotropil on rat brain neurotransmitter receptors during testing of the conditioned passive avoidance task

Thanks .

"Phenotropil considerably increased the density of dopamine D2 and D3 receptors by 29% and 62%, respectively."

That explains some of the effects I feel from phenylpiracetam. I noticed it basically comes down to feeling higher social status.
A few days ago I stumbled upon a study showing, increased D2 and D3 receptor density directly correlating with higher social status .

"Dr. Martinez and colleagues found that increased social status and increased social support correlated with the density of dopamine D2/D3 receptors in the striatum, a region of the brain that plays a central role in reward and motivation, where dopamine plays a critical role in both of these behavioral processes."

Press releases | Elsevier

Press release news service - Full overview of the main news and business updates.

www.elsevier.com

 

[golder]

Thanks .

"Phenotropil considerably increased the density of dopamine D2 and D3 receptors by 29% and 62%, respectively."

That explains some of the effects I feel from phenylpiracetam. I noticed it basically comes down to feeling higher social status.
A few days ago I stumbled upon a study showing, increased D2 and D3 receptor density directly correlating with higher social status .

"Dr. Martinez and colleagues found that increased social status and increased social support correlated with the density of dopamine D2/D3 receptors in the striatum, a region of the brain that plays a central role in reward and motivation, where dopamine plays a critical role in both of these behavioral processes."

Press releases | Elsevier

Press release news service - Full overview of the main news and business updates.

www.elsevier.com

One says it increased density of dopamine receptors, one says the opposite. What’s the verdict? ?

 

[Mauritio]

One says it increased density of dopamine receptors, one says the opposite. What’s the verdict? ?

One study is in Russian so we cant check how legit it is. So itd give the benefit of the doubt to Hans's study . But it we have to remember that all these effects were after they had already given scopolamine . So the scopolamine might have created a new baseline to which phenylpiracetam might have reacted differently to then if they hadn't received scopolamine .
I'll check if I can get the full text .
Plus from personal experience I can attest to that it feels dopaminergic .

 

[Mauritio]

I found some interesting quotes in the full study :

Piracetam and phenotropil increase the dopamine and noradrenaline content in the brain [1, 4].

7-fold administrations of phenotropil induced an increase indensities of NMDA receptors in the hippocampus, nicotinic receptors in the cortex, and D3-dopamine receptors in the striatum [3]

Piracetam is an agonist of
glutamate quisqualate autoreceptors [7]

 

[golder]

I found some interesting quotes in the full study :

Piracetam and phenotropil increase the dopamine and noradrenaline content in the brain [1, 4].

7-fold administrations of phenotropil induced an increase indensities of NMDA receptors in the hippocampus, nicotinic receptors in the cortex, and D3-dopamine receptors in the striatum [3]

Piracetam is an agonist of
glutamate quisqualate autoreceptors [7]

Thanks for these Mauritio, presumably the last claim being the only cause for concern?
‘‘Piracetam is an agonist of
glutamate quisqualate autoreceptors [7]’’

 

[Mauritio]

Thanks for these Mauritio, presumably the last claim being the only cause for concern?
‘‘Piracetam is an agonist of
glutamate quisqualate autoreceptors [7]’’

As I understand it the activation of the autoreceptor leads to a downregualtio of the output of the same type of hormone/neurotransmitter . For example 5ht1a is the autoreceptor for serotonin, its activation leads to lower serotonin levels.

So piracetam consumption will actually lead to lower glutamate levels .

 

[Razvan]

As I understand it the activation of the autoreceptor leads to a downregualtio of the output of the same type of hormone/neurotransmitter . For example 5ht1a is the autoreceptor for serotonin, its activation leads to lower serotonin levels.

So piracetam consumption will actually lead to lower glutamate levels .

Yes as you know from my experience.
Piracetam it's not stimulating in a bad way,feels very gaba agonistic and euphoric. It's not how people expect to be.

 

[golder]

Yes as you know from my experience.
Piracetam it's not stimulating in a bad way,feels very gaba agonistic and euphoric. It's not how people expect to be.

Nice. What dose piracetam did you use?
Have you tried phenylpiracetam?

 

[Razvan]

Nice. What dose piracetam did you use?
Have you tried phenylpiracetam?

I use piracetam sporadically,very good stuff.
I use from 1.2g to 2.5g.
I haven't tried phenylpyracetam.

 

[db9]

What

I'm not convinced about the cancer connection. It was only an in vitro study, so nothing conclusive. I still think taking it 2-3 times per week should be safe if you get enough vitamins and minerals.

Abstaining will only be most beneficial if watching porn and masturbating in excess. If done infrequently, then it will most like only have a minor effect. Avoiding porn will have the biggest beneficial effect imo.

Yes, but a lot of substances can increase both serotonin and dopamine, such as vitamin D. Serotonin can also increase dopamine through 5-HT2A. Not that I'm saying serotonin in good lol.

What about sex Hans, doesn’t it downregulate dopamine receptors? Especially if you are having sex everyday and sometimes twice per day?

 

[DonLore]

I would stick to the basics of glucose oxidation as much as possible, such as vitamin B1 (and other Bs), magnesium, aspirin and Pyrucet. Then in terms of a herb, I like tribulus and (very occasional) Kratom (I don't feel anything from most dopaminegics), but I don't need it when every other aspect of dopamine optimization is in place, such as sleep, sunlight, proper training, no gut irritation, nutrition food, etc.

Sorry for replying to old message, but isnt maybe the most important thing out of all things, a high social status and rich social life? (Of course provided that physical health is good). Since having a high social circle increases dopamine and D receptors, lowers cortisol and gives that 'winning' attitude. Good physical health + sun + lots of social interaction makes me euphoric itself

 

[Hans]

What

What about sex Hans, doesn’t it downregulate dopamine receptors? Especially if you are having sex everyday and sometimes twice per day?

I don't think it will no. If you got dopamine desensitization, prolactin would go up and your libido would go down.

 

[Hans]

Sorry for replying to old message, but isnt maybe the most important thing out of all things, a high social status and rich social life? (Of course provided that physical health is good). Since having a high social circle increases dopamine and D receptors, lowers cortisol and gives that 'winning' attitude. Good physical health + sun + lots of social interaction makes me euphoric itself

For sure, that's very important. In a lot of cases, that would be enough. But in my case, years ago, and for other people as well, being with others makes them too anxious to get the full benefit. So then focusing on the metabolism, etc., can help a lot to improve the benefits of having a high social circle.

 

[Jinzo]

If you are trying to restore/resensitize dopamine receptors it is better to stay away from dopamine supplements right?

Less dopamine = upregulation of receptors is my thinking

So no lisuride, metergoline, cypro...and even other more natural substances that boost dopamine as well? How long would it take to resensitize you think?

 

[Hans]

If you are trying to restore/resensitize dopamine receptors it is better to stay away from dopamine supplements right?

Less dopamine = upregulation of receptors is my thinking

So no lisuride, metergoline, cypro...and even other more natural substances that boost dopamine as well? How long would it take to resensitize you think?

I'd stay away from D2 agonists for sure, but not all natural boosters will downregulate dopamine receptors. Many herbs also increase dopamine receptors. I'd focus on boosting dopamine via oysters, milk, sunlight, proper sleep, fruit, exercise, keeping the gut clean, etc. That should be the baseline and once you have that in check, you won't need pro-dopamine substances.

 

[NewACC]

One study is in Russian so we cant check how legit it is. So itd give the benefit of the doubt to Hans's study . But it we have to remember that all these effects were after they had already given scopolamine . So the scopolamine might have created a new baseline to which phenylpiracetam might have reacted differently to then if they hadn't received scopolamine .
I'll check if I can get the full text .
Plus from personal experience I can attest to that it feels dopaminergic .

I'm sorry, for writing too late, but I have full text

 

[Mauritio]

Phenylpiracetam has an anti-endotoxin and anti-inflammatory effects and increases dopamine via DAT inhibition!

Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice - PubMed

R-phenylpiracetam (R-PhP, (4R)-2-(4-phenyl-2-oxopyrrolidin-1-yl)acetamide) is an optical isomer of phenotropil, a clinically-used nootropic drug that improves physical condition and cognition. Recently, R-PhP was shown to bind to the dopamine transporter (DAT). Since growing evidence suggests...

pubmed.ncbi.nlm.nih.gov

 

[Mauritio]

Phenylpiracetam lowers weight gain on a hypercaloric diet. It looks like increase in leptin/insulin sensitivity, increase in the metabolic rate via increase in dopamine and appetite suppression are the mechanisms of action here.
I also found it a little easier to lose weight and noticed a appetite suppression on it.

"Compared to the WD
control group, the fat mass decreased significantly by 45% and 69% in the WD-fed mice after 8 weeks of treatment with S- and R-phenylpiracetam, respectively (Fig. 3B)."

S-phenylpiracetam, a selective DAT inhibitor, reduces body weight gain without influencing locomotor activity - PubMed

S-phenylpiracetam is an optical isomer of phenotropil, which is a clinically used nootropic drug that improves physical condition and cognition. Recently, it was shown that S-phenylpiracetam is a selective dopamine transporter (DAT) inhibitor that does not influence norepinephrine (NE) or...

pubmed.ncbi.nlm.nih.gov

 

[golder]

that’s some great finds Mauritio. What dosages have you found beneficial with phenylpiracetam?

 

[Androsclerosis]

We don't have to forget how maladaptive daydreaming desensitize dopamine receptors. People who went through high stress at some point experience excessive daydreaming which acts as masturbation.
After we stop daydreaming, the first days boringness will come and your mind will push you towards daydreaming but we have to put resistance.
Of course, having high dopamine levels will make easier for a person to switch to present moment. I noticed B1 helps knowing that increases cognitive function.
During next days I will see how it is with 1.5g of B1 and 150% RDA Magnesium.