How To Boost Dopamine Receptors

[GorillaHead]

For 4 months i couldnt stay in my house, i only wanted to party ,see nature and socialize,i was fearless ,i was a machine bro. It was amazing and when i took the full dose i Indeed got a bad trip but still ended up with positive effects If You survive the bad trip You Will feel like god.

The way u talk about it is either highly highly over exaggerated Or u just had a rare effect cause I assure u its not that life changing. At least for me. Pretty standard stuff

 

[Mauritio]

For 4 months i couldnt stay in my house, i only wanted to party ,see nature and socialize,i was fearless ,i was a machine bro. It was amazing and when i took the full dose i Indeed got a bad trip but still ended up with positive effects If You survive the bad trip You Will feel like god.

Cool ,makes me really want to try it . How much did you take? And did you do it by yourself or did you have some who took care of you?

 

[Razvan]

The way u talk about it is either highly highly over exaggerated Or u just had a rare effect cause I assure u its not that life changing. At least for me. Pretty standard stuff

I swear i'm not exagerating, during the bad trip i was seeing all my friends with 5 eyes and had 140 pulse for 8 hours. I swear i'm not exagerating it changed my whole summer,every color was different and everything was more interesting after the trip

 

[Razvan]

Cool ,makes me really want to try it . How much did you take? And did you do it by yourself or did you have some who took care of you?

I took it with one of my best friends and we took 200 mg each i think but i don't know sure,we did go to a forest and we couldn't get out of it i was having true hallucinations and my small town did seem like rio the janeiro.Amazing experience!You need to do it with someone that you are very close otherwise you easily go into bad trip, even tho I still got the bad trip.

 

[Razvan]

The way u talk about it is either highly highly over exaggerated Or u just had a rare effect cause I assure u its not that life changing. At least for me. Pretty standard stuff

Maybe you got the fake NBOMB stuff. Lsd it's very hard to find it without being faked, especially in the western europe.

 

[vetbusd]

This makes me feel like my ED is caused by dopamine imbalance.

For months I feel impulsive, I cant do anything other than look at my crypto portfolio every 30seconds. Havent been outside in weeks, but dont feel like going out either. My symptoms are exactly what you wrote, I literally cannot focus on anything for more than a few minutes.

• Lack of motivation, no goal setting or ambition, lack of self-grooming
• No creativity, brain fog, low problem solving ability
• Don’t want to explore, not curious, closed minded
• Anhedonia, lack of pleasure, don’t enjoy much, negativity (rarely happy), no humor, disconnected
• Diminished ability or just don’t want to connect with people
• Lack of content, no purpose or beauty in life
• Anti-social / social anxiety, fearful, nervous, anxious
• Attention deficit, short term memory loss, etc…
• Low appetite (because of elevated serotonin)
• High prolactin
• Might increase dependence of stimulants

@Hans I know you post a lot about Dopamine on your forum. Do you have any knowledge with a detox to reset dopamine sensitivety?
You have written some things which make me think that we can control it with our brain. Thanks again

 

[Razvan]

This makes me feel like my ED is caused by dopamine imbalance.

For months I feel impulsive, I cant do anything other than look at my crypto portfolio every 30seconds. Havent been outside in weeks, but dont feel like going out either. My symptoms are exactly what you wrote, I literally cannot focus on anything for more than a few minutes.

• Lack of motivation, no goal setting or ambition, lack of self-grooming
• No creativity, brain fog, low problem solving ability
• Don’t want to explore, not curious, closed minded
• Anhedonia, lack of pleasure, don’t enjoy much, negativity (rarely happy), no humor, disconnected
• Diminished ability or just don’t want to connect with people
• Lack of content, no purpose or beauty in life
• Anti-social / social anxiety, fearful, nervous, anxious
• Attention deficit, short term memory loss, etc…
• Low appetite (because of elevated serotonin)
• High prolactin
• Might increase dependence of stimulants

@Hans I know you post a lot about Dopamine on your forum. Do you have any knowledge with a detox to reset dopamine sensitivety?
You have written some things which make me think that we can control it with our brain. Thanks again

You might want to lower prolactin to boost dopamine levels. Methylene blue ,vitamin E and tribulus terrestris are very good for doing it. Or the product from Haidut 5-dhp can lower prolactin very well in higher dosages.

 

[Hans]

This makes me feel like my ED is caused by dopamine imbalance.

For months I feel impulsive, I cant do anything other than look at my crypto portfolio every 30seconds. Havent been outside in weeks, but dont feel like going out either. My symptoms are exactly what you wrote, I literally cannot focus on anything for more than a few minutes.

• Lack of motivation, no goal setting or ambition, lack of self-grooming
• No creativity, brain fog, low problem solving ability
• Don’t want to explore, not curious, closed minded
• Anhedonia, lack of pleasure, don’t enjoy much, negativity (rarely happy), no humor, disconnected
• Diminished ability or just don’t want to connect with people
• Lack of content, no purpose or beauty in life
• Anti-social / social anxiety, fearful, nervous, anxious
• Attention deficit, short term memory loss, etc…
• Low appetite (because of elevated serotonin)
• High prolactin
• Might increase dependence of stimulants

@Hans I know you post a lot about Dopamine on your forum. Do you have any knowledge with a detox to reset dopamine sensitivety?
You have written some things which make me think that we can control it with our brain. Thanks again

It can also be a symptom of overmethylation or detoxing dopamine too fast. Meaning, dopamine and noradrenaline help with focus. If you break it down too fast, you can't enjoy anything for too long and can't stay focused for too long. So inhibiting COMT and MAO-B can help to increase dopamine and improve your focus. Niacinamide can lower methylation and hordenine can block MAO-B.
Perhaps you can try aspirin (to stop brain overexcitation), niacinamide, vitamin B1 and hordenine. Perhaps also theanine or theacrine for calming the brain.
Boosting glucose oxidation in the brain is key of focus, so niacinamide, vitamin B1, aspirin and Pyrucet work great for that in my experience.

 

[vetbusd]

It can also be a symptom of overmethylation or detoxing dopamine too fast. Meaning, dopamine and noradrenaline help with focus. If you break it down too fast, you can't enjoy anything for too long and can't stay focused for too long. So inhibiting COMT and MAO-B can help to increase dopamine and improve your focus. Niacinamide can lower methylation and hordenine can block MAO-B.
Perhaps you can try aspirin (to stop brain overexcitation), niacinamide, vitamin B1 and hordenine. Perhaps also theanine or theacrine for calming the brain.
Boosting glucose oxidation in the brain is key of focus, so niacinamide, vitamin B1, aspirin and Pyrucet work great for that in my experience.

Sorry I should have been more clear. I am asking about doing a detox, not saying that I did a detox previously.

I read all your posts about Dopamine and Serotonin. And this graph

If we look at an addiction model, each time we do something, the dopamine released has diminishing returns.

Could it be that I have sensitized myself so much by doing the same actions (eating,drinking,compulsive social media and crypto,and PMO) that completely abstaining from all my impulsions would be benifitial? The only way to restore everything is to do 1month of nothing.
Clean healthy foods, voluntary discomfort, no vices ect.

I really appreciate your suggestions for supplements but I am terrified of taking anything which could mess with me in the long run.

 

[Hans]

Sorry I should have been more clear. I am asking about doing a detox, not saying that I did a detox previously.

I read all your posts about Dopamine and Serotonin. And this graph
View attachment 21948
If we look at an addiction model, each time we do something, the dopamine released has diminishing returns.
View attachment 21949


Could it be that I have sensitized myself so much by doing the same actions (eating,drinking,compulsive social media and crypto,and PMO) that completely abstaining from all my impulsions would be benifitial? The only way to restore everything is to do 1month of nothing.
Clean healthy foods, voluntary discomfort, no vices ect.

I really appreciate your suggestions for supplements but I am terrified of taking anything which could mess with me in the long run.

Impulsiveness is just a sign that something else is wrong. So the impulsiveness is more likely a sign of dopamine dysregulation, so abstaining will not solve it. It might improve it, but not solve it, unless a solution is implemented during abstinence.
That's why I mentioned fixing the root that will solve the dopamine dysregulation and then the desire to be impulsive will also go away.
Radical mood changes are possible with things like aspirin, progesterone, cypro, Naloxone, clonidine, thyroid, etc. Some people might think that progesterone castrated them just because they don't have the desire to watch porn and masturbate 5 times a day. Like how is that normal?

 

[Razvan]

True ,go

Impulsiveness is just a sign that something else is wrong. So the impulsiveness is more likely a sign of dopamine dysregulation, so abstaining will not solve it. It might improve it, but not solve it, unless a solution is implemented during abstinence.
That's why I mentioned fixing the root that will solve the dopamine dysregulation and then the desire to be impulsive will also go away.
Radical mood changes are possible with things like aspirin, progesterone, cypro, Naloxone, clonidine, thyroid, etc. Some people might think that progesterone castrated them just because they don't have the desire to watch porn and masturbate 5 times a day. Like how is that normal?

True, got that feeling of "castration" with methylene blue , just thinking of porn will make me puke. And i took it as a positive.

 

[Cloudhands]

Lsd can certainly be life changing. Same with mushrooms. If you dont think they can, you probably havent been that deep in the trip. ***t can be crazy lol.

 

[Razvan]

Lsd can certainly be life changing. Same with mushrooms. If you dont think they can, you probably havent been that deep in the trip. ***t can be crazy lol.

***t's deep brah

 

[Cloudhands]

***t's deep brah

Yeah, ive had some crazy experiences and realizations that transcend space and time lol

 

[Razvan]

Yeah, ive had some crazy experiences and realizations that transcend space and time lol

Same bro I was hearing stuff 200xtimes better,changed my life ffs

 

[Mauritio]

About phenylpiracetam:

 

[Mauritio]

Hi all,

Not only can dopamine levels be an issue, but also dopamine sensitivity. Often times there can be a dopamine hypo-sensitivity, so I've written an article on how to increase dopamine receptors.

Dopamine receptors: 14 Best supplements and practices and to increase it » MenElite

Let me know your thoughts and what has worked for you for improving dopamine sensitivity or just general euphoria in life.

@Hans under phenylpiracetam you say :
"Increases the dopamine D1, D2 and D3 receptors"

Do you have a reference for that ?
I'm on day 8 of taking it and I actually have a reference stating that it decreases serotonin and dopamine receptors in the brain, so I just want to make sure I'm not damaging myself with long term administration.

 

[Hans]

N

@Hans under phenylpiracetam you say :
"Increases the dopamine D1, D2 and D3 receptors"

Do you have a reference for that ?
I'm on day 8 of taking it and I actually have a reference stating that it decreases serotonin and dopamine receptors in the brain, so I just want to make sure I'm not damaging myself with long term administration.

Not sure why I didn't include the study there. Here it is: The effects of scopolamine and the nootropic drug phenotropil on rat brain neurotransmitter receptors during testing of the conditioned passive avoidance task

 

[golder]

@Hans under phenylpiracetam you say :
"Increases the dopamine D1, D2 and D3 receptors"

Do you have a reference for that ?
I'm on day 8 of taking it and I actually have a reference stating that it decreases serotonin and dopamine receptors in the brain, so I just want to make sure I'm not damaging myself with long term administration.

Could you post your conflicting study so Hans and others can compare. Thanks!

 

[Mauritio]

Could you post your conflicting study so Hans and others can compare. Thanks!

" The affinity of phenylpiracetam to the nicotinitic acetylcholine (nACh) receptor, but not the glutamate NMDA subtype, was demonstrated in ligand-binding experiments in vitro. However, injection of this drug (100 mg/kg, intraperitoneally) to rats increases the numbers of both nACh and NMDA receptors, but decreases serotonin and dopamine
receptors in the brain tissue.[40]"
This quote is from the study I attached.

I tried to look for the cited study [40] but it's in Russian...