How high-fat diets allow cancer cells to go unnoticed

[Mito]

Summary:
The immune system relies on cell surface tags to recognize cancer cells. Researchers discovered mice who ate high-fat diets produced less of these tags on their intestinal cells, suppressing the ability of immune cells to identify and eliminate intestinal tumors. The high-fat diet also reduced the presence of certain bacteria in the mice's gut, which normally helps maintain the production of these tags.

How high-fat diets allow cancer cells to go unnoticed

The immune system relies on cell surface tags to recognize cancer cells. Researchers discovered mice who ate high-fat diets produced less of these tags on their intestinal cells, suppressing the ability of immune cells to identify and eliminate intestinal tumors. The high-fat diet also reduced...

www.sciencedaily.com

 

[milkboi]

Very interesting find

 

[Jam]

FWIW, in the vast, vast majority of these studies, high fat diets are high PUFA diets, and I'm definitely not going to pay to find out what kind of chow they used.

 

[ecstatichamster]

FWIW, in the vast, vast majority of these studies, high fat diets are high PUFA diets, and I'm definitely not going to pay to find out what kind of chow they used.

yes true. Chow always contains high PUFAs unless specifically stated otherwise.

 

[lampofred]

This is extremely interesting. Thanks for posting.

 

[Lejeboca]

FWIW, in the vast, vast majority of these studies, high fat diets are high PUFA diets, and I'm definitely not going to pay to find out what kind of chow they used.

It´s research diet D12492: 60% fat, 20% C and 20% P. For the fat its 245g lard and 25g soybean oil. (D12492 Formula - Search Formulas - Research Diets, Inc.)
The controls were fed ad lib o a standard diet of 14% fat, 60% C, and 26% P.
Found a preprint of their paper in bioarXiv:
Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis

 

[Rasaari]

Damn that's insane amount of fat. The lard is probably 30% Pufa.

 

[Lollipop2]

Damn that's insane amount of fat. The lard is probably 30% Pufa.

Waaaaay more as pigs are all fed high PUFA grains.

 

[Rasaari]

Waaaaay more as pigs are all fed high PUFA grains.

No, the PUFA fed animals in USA are about 30% PUFA, regular pork here in northern europe is 10%. The hog genetics also matter, as the hog industry have bred these ultra-lean pigs so they are very bad at de novo lipogenesis, aka making MUFAs and SFAs from starch that they eat, so the only fat source for these hogs is the diet.

 

[Lollipop2]

No, the PUFA fed animals in USA are about 30% PUFA, regular pork here in northern europe is 10%. The hog genetics also matter, as the hog industry have bred these ultra-lean pigs so they are very bad at de novo lipogenesis, aka making MUFAs and SFAs from starch that they eat, so the only fat source for these hogs is the diet.

Have never heard this. Common knowledge on this forum is the high PUFA content of pigs today due to “vegetarian fed diet”. Pigs fed milk, table scraps are apparently low PUFA.

 

[MayaPapaya]

It´s research diet D12492: 60% fat, 20% C and 20% P. For the fat its 245g lard and 25g soybean oil. (D12492 Formula - Search Formulas - Research Diets, Inc.)
The controls were fed ad lib o a standard diet of 14% fat, 60% C, and 26% P.
Found a preprint of their paper in bioarXiv:
Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis

Thank you!