How does one avoid cellular tissue hypoxia ?

[GorillaHead]

Reading about how hypoxia and cancers has got me interested in ways to avoid oxygen deprivation to the tissues. What are ways or nutrients that essential to avoiding lack of oxygen which in turn reprograms mitochondria ?

 

[LLight]

Lowering water retention?

 

[LLight]

The association of adrenaline and EPO with both edema elimination (Fig. 2) and improved cellular oxygenation raises the question of whether edema elimination and improved cellular oxygenation are causally linked. This question is apparently of paramount therapeutic importance.

Dry Fasting Physiology: Responses to Hypovolemia and Hypertonicity

Abstract. Objective: The aim of this study was to provide a deeper insight into dry fasting (DF) physiology. Design: Ten participants performed DF for 5 consecutive days. Methods: The following parameters were monitored daily: cortisol, aldosterone, high-sensitivity C-reactive protein (CRP)...

www.karger.com

 

[GorillaHead]

Dry Fasting Physiology: Responses to Hypovolemia and Hypertonicity

Abstract. Objective: The aim of this study was to provide a deeper insight into dry fasting (DF) physiology. Design: Ten participants performed DF for 5 consecutive days. Methods: The following parameters were monitored daily: cortisol, aldosterone, high-sensitivity C-reactive protein (CRP)...

www.karger.com

Interesting. very interesting. I know personally when I supplemented iron once I would get dehydrated easily

 

[LLight]

CFS is a disease of water homeostasis it seems. They have low vasopressin but tend to retain water (so cellular edema) if I remember correctly.

They also have low manganese in their tissues. Manganese is used by an enzyme (MnSOD) that detoxifies ROS in the mitochondria.

Water restriction/lowered edema might increase ROS.

Could water retention be a consequence of a lack of manganese? The body would retain water such that metabolism is not increased and ROS is not created (or not as much as with normal metabolism). Hypoxia would be a consequence more than a cause.

 

[LLight]

The dysfunction of metabolic controlling of cell hydration precedes Warburg phenomenon in carcinogenesis

"At present, cancer is one of the major causes of death worldwide. However, the detailed mechanism of carcinogenesis is not clear yet.

More than 80 years ago Nobel Prize laureate Warburg pointed out that in cancerous cell the loss of oxidative capacity of mitochondria and the glycolytic metabolism shift relative to oxidative phosphorylation as O2 could not reach to mitochondria [1]. However, the nature of the
primary mechanism leading to generation of Warburg phenomenon has not been elucidated yet.

In 1971 the second revolutionary discovery was made in cancer research by Raymond Damadian, who elucidated that cancerous cell is markedly overhydrated and can be much as 90% water while in norm it can be 70-73%. “Magnetic Resonance” method [2] of detection of cell over hydration suggested by him which serves as an early tumor detection diagnostic method at present has a worldwide clinical usage.
It is established that cell swelling triggers its proliferation, while cell shrinkage promotes its apoptosis [3-6]. Cell hydration causes not only the promotion of cell division and oncogene expression but also inactivates genes inducing cell apoptosis [7]. On the basis of these data cell over hydration was suggested as a primary messenger in carcinogenesis [3,7]. However, the nature of metabolic mechanism the dysfunction of which causes over hydration in cancer cells as well as the link between cell over hydration and Warburg phenomenon are also not elucidated yet. Therefore, it is suggested that the discovery of intracellular signaling pathway through which the correlation between cell hydration and mitochondrial function is realized could be one of the key problems of modern cancer research."

 

[Kram]

Parent Essential Oils (PEOS) - Improve Cellular Oxygenation

Parent Essential Oils (PEOs) are thin, oxygen attracting oils that come from seeds and other foods, and that incorporate into cell membranes and increase cellular oxygenation - leading to improved cellular function and health.

oxygen4cells.com

 

[Sila]

Increasing co2 retention by doing reduced breathing (buteyko) or using frolov device.

Bohr Effect Oxygen Release Explained in 5 Min : Healthy vs. Sick People

Bohr Effect Oxygen Release Explained: Healthy vs. Sick People : Oxygen release by hemoglobin in red blood cells is caused by CO2: graph-diagram for Bohr effect for dummies

www.normalbreathing.com

 

[Perry Staltic]

Habitual aerobic exercise induces vascular remodeling that promotes oxygenation of tissues. Doesn't have to be a lot, but it does have to be habitual. Increase as you feel benefit, but always do the baseline.

 

[mostlylurking]

Reading about how hypoxia and cancers has got me interested in ways to avoid oxygen deprivation to the tissues. What are ways or nutrients that essential to avoiding lack of oxygen which in turn reprograms mitochondria ?

For your consideration:

Quick Thoughts: Thiamine, Hypoxia, and Bowel Function - Hormones Matter

The same proteins that are upregulated with insufficient thiamine, also downregulate the very nutrient required to resolve the hypoxia.

www.hormonesmatter.com

Dysautonomia and Hypoxia - Hormones Matter

Is thiamine deficiency and the resultant hypoxia involved in the myriad of autonomically controlled systems currently labeled dysautonomia?

www.hormonesmatter.com

Thiamine and magnesium deficiencies: keys to disease - PubMed

Thiamine deficiency (TD) is accepted as the cause of beriberi because of its action in the metabolism of simple carbohydrates, mainly as the rate limiting cofactor for the dehydrogenases of pyruvate and alpha-ketoglutarate, both being critical to the action of the citric acid cycle...

pubmed.ncbi.nlm.nih.gov

"...mild to moderate TD results in pseudo hypoxia in the limbic system and brainstem...."

 

[Elast1c]

For your consideration:

Quick Thoughts: Thiamine, Hypoxia, and Bowel Function - Hormones Matter

The same proteins that are upregulated with insufficient thiamine, also downregulate the very nutrient required to resolve the hypoxia.

www.hormonesmatter.com

Dysautonomia and Hypoxia - Hormones Matter

Is thiamine deficiency and the resultant hypoxia involved in the myriad of autonomically controlled systems currently labeled dysautonomia?

www.hormonesmatter.com

Thiamine and magnesium deficiencies: keys to disease - PubMed

Thiamine deficiency (TD) is accepted as the cause of beriberi because of its action in the metabolism of simple carbohydrates, mainly as the rate limiting cofactor for the dehydrogenases of pyruvate and alpha-ketoglutarate, both being critical to the action of the citric acid cycle...

pubmed.ncbi.nlm.nih.gov

"...mild to moderate TD results in pseudo hypoxia in the limbic system and brainstem...."

Nice

 

[oxphoser]

Increasing co2 retention by doing reduced breathing (buteyko) or using frolov device.

Bohr Effect Oxygen Release Explained in 5 Min : Healthy vs. Sick People

Bohr Effect Oxygen Release Explained: Healthy vs. Sick People : Oxygen release by hemoglobin in red blood cells is caused by CO2: graph-diagram for Bohr effect for dummies

www.normalbreathing.com

Or bag breathing.

 

[mostlylurking]

On the basis of these data cell over hydration was suggested as a primary messenger in carcinogenesis [

Consider this possible connection:

Wernicke encephalopathy

CONTENTS Rapid Reference 🚀 Pathophysiology Signs & Symptoms Risk factors Epidemiology Laboratory studies Imaging Differential diagnosis & securing the diagnosis Prevention Treatment Prognosis Related topics Metronidazole induced encephalopathy (MIE) Podcast Questions & discussion Pitfalls...

emcrit.org

biochemistry​

• Thiamine is a co-factor in numerous enzymatic reactions involved in energy metabolism, as shown below. Thiamine deficiency has consequences including the following:
  • (1) Accumulation of lactate
  • (2) Excess production of glutamate, which may lead to excessive excitatory neurotransmission in the brain
• This can cause vasogenic and cytotoxic edema.

also there's a correlation between thiamine deficiency and cancer:

Thiamin deficiency: a possible major cause of some tumors? (review) - PubMed

Based solely on clinical clues from a malnourished population, thiamin alone was intentionally and successfully injected to human cases with some tumors or masses. Two cases of submandibular gland cyst and 13 out of 15 cases of Baker's cyst were cured without recurrence for several decades. In a...

pubmed.ncbi.nlm.nih.gov

There have been studies that show that low dose thiamine supplementation may increase cancer growth whereas high dose thiamine supplementation suppresses cancer.

High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate - PubMed

Our findings suggest that high-dose thiamine reduces cancer cell proliferation by a mechanism similar to that described for dichloroacetate.

pubmed.ncbi.nlm.nih.gov

The role of thiamine in cancer: possible genetic and cellular signaling mechanisms - PubMed

The relationship between supplemental vitamins and various types of cancer has been the focus of recent investigation, and supplemental vitamins have been reported to modulate cancer rates. A significant association has been demonstrated between cancer and low levels of thiamine in the serum...

pubmed.ncbi.nlm.nih.gov

 

[A.R]

Consider this possible connection:

Wernicke encephalopathy

CONTENTS Rapid Reference 🚀 Pathophysiology Signs & Symptoms Risk factors Epidemiology Laboratory studies Imaging Differential diagnosis & securing the diagnosis Prevention Treatment Prognosis Related topics Metronidazole induced encephalopathy (MIE) Podcast Questions & discussion Pitfalls...

emcrit.org

biochemistry​

• Thiamine is a co-factor in numerous enzymatic reactions involved in energy metabolism, as shown below. Thiamine deficiency has consequences including the following:
  • (1) Accumulation of lactate
  • (2) Excess production of glutamate, which may lead to excessive excitatory neurotransmission in the brain
• This can cause vasogenic and cytotoxic edema.

also there's a correlation between thiamine deficiency and cancer:

Thiamin deficiency: a possible major cause of some tumors? (review) - PubMed

Based solely on clinical clues from a malnourished population, thiamin alone was intentionally and successfully injected to human cases with some tumors or masses. Two cases of submandibular gland cyst and 13 out of 15 cases of Baker's cyst were cured without recurrence for several decades. In a...

pubmed.ncbi.nlm.nih.gov

There have been studies that show that low dose thiamine supplementation may increase cancer growth whereas high dose thiamine supplementation suppresses cancer.

High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate - PubMed

Our findings suggest that high-dose thiamine reduces cancer cell proliferation by a mechanism similar to that described for dichloroacetate.

pubmed.ncbi.nlm.nih.gov

The role of thiamine in cancer: possible genetic and cellular signaling mechanisms - PubMed

The relationship between supplemental vitamins and various types of cancer has been the focus of recent investigation, and supplemental vitamins have been reported to modulate cancer rates. A significant association has been demonstrated between cancer and low levels of thiamine in the serum...

pubmed.ncbi.nlm.nih.gov

Interesting. Would you know what was the actual low dose of thiamine which increases cancer growth ?

 

[mostlylurking]

Interesting. Would you know what was the actual low dose of thiamine which increases cancer growth ?

I can't find the study I was remembering, but I did find this article:

Thiamine may suppress cancer

Thiamine, vitamin B1, treats altitude sickness and even suppresses cancer tumors! There's a lot more to this B vitamin that we thought!

www.dailymedicaldiscoveries.com

I found the article finally:

Linking vitamin B1 with cancer cell metabolism - Cancer & Metabolism

The resurgence of interest in cancer metabolism has linked alterations in the regulation and exploitation of metabolic pathways with an anabolic phenotype that increases biomass production for the replication of new daughter cells. To support the increase in the metabolic rate of cancer cells, a...

cancerandmetabolism.biomedcentral.com

"In 2001, Comin-Anduix et al. evaluated the effect of increasing thiamine supplementation in multiples of the RDI on an Ehrlich ascites tumor-mouse model [58]. Their findings indicated a statistically significant stimulatory effect of thiamine supplementation on tumor growth compared to non-supplemented controls. Moderate doses of 12.5 to 37.5 times the RDI had the greatest stimulatory effect, peaking at approximately 250% greater tumor cell proliferation with 25 times the RDI. Interestingly, at values above 75 times the RDI, no change was found in tumor cell proliferation, and a slight decrease was found at 2,500 times the RDI. This observation suggests that there is a specific range in which thiamine supports proliferation."

RDI for thiamine: Vitamin B1 (Thiamine) - StatPearls - NCBI Bookshelf
"The recommended daily intake (RDI) for adults over age eighteen is 1.2 mg/day for men and 1.1 mg/day for women. For children, adequate intake levels are lower. Women of any age who are pregnant should increase their daily intake of thiamin to 1.4 mg/day."

 

[A.R]

I can't find the study I was remembering, but I did find this article:

Thiamine may suppress cancer

Thiamine, vitamin B1, treats altitude sickness and even suppresses cancer tumors! There's a lot more to this B vitamin that we thought!

www.dailymedicaldiscoveries.com

I found the article finally:

Linking vitamin B1 with cancer cell metabolism - Cancer & Metabolism

The resurgence of interest in cancer metabolism has linked alterations in the regulation and exploitation of metabolic pathways with an anabolic phenotype that increases biomass production for the replication of new daughter cells. To support the increase in the metabolic rate of cancer cells, a...

cancerandmetabolism.biomedcentral.com

"In 2001, Comin-Anduix et al. evaluated the effect of increasing thiamine supplementation in multiples of the RDI on an Ehrlich ascites tumor-mouse model [58]. Their findings indicated a statistically significant stimulatory effect of thiamine supplementation on tumor growth compared to non-supplemented controls. Moderate doses of 12.5 to 37.5 times the RDI had the greatest stimulatory effect, peaking at approximately 250% greater tumor cell proliferation with 25 times the RDI. Interestingly, at values above 75 times the RDI, no change was found in tumor cell proliferation, and a slight decrease was found at 2,500 times the RDI. This observation suggests that there is a specific range in which thiamine supports proliferation."

RDI for thiamine: Vitamin B1 (Thiamine) - StatPearls - NCBI Bookshelf
"The recommended daily intake (RDI) for adults over age eighteen is 1.2 mg/day for men and 1.1 mg/day for women. For children, adequate intake levels are lower. Women of any age who are pregnant should increase their daily intake of thiamin to 1.4 mg/day."

“Interestingly, at values above 75 times the RDI, no change was found in tumor cell proliferation”

“The recommended daily intake (RDI) for adults over age eighteen is 1.2 mg/day for men and 1.1 mg/day for women”

So 75 x 1.2 = 90

So by my calculations, if a person stays above 90mg thiamine, they are safe from the cancer effects. Did I work that out properly?

 

[GorillaHead]

doesn’t thiamine also reduce iron ?


here is what I am thinking is a good solution to keep oxygenation high. 5mg of a safe iron supplement daily. 2.5mg of Copper. 500mg of thiamine. 100mg of riboflsvin and 1 gram of myoinositol and vitamin E to counteract iron oxidation and overload

 

[mostlylurking]

“Interestingly, at values above 75 times the RDI, no change was found in tumor cell proliferation”

“The recommended daily intake (RDI) for adults over age eighteen is 1.2 mg/day for men and 1.1 mg/day for women”

So 75 x 1.2 = 90

So by my calculations, if a person stays above 90mg thiamine, they are safe from the cancer effects. Did I work that out properly?

yes. But that may not be enough for your needs, it could be though. Lots of variables.