How Do Cyproheptadine And Mirtazapine Induce Sleep And Increase Appetite?

[Logan-]

What are the main mechanisms for these effects? Is it the anti serotonin action, anti histamine, or both together? Or something else?

@DaveFoster could you explain, in detail?

 

[Murtaza]

they lower cortisol

 

[redsun]

What are the main mechanisms for these effects? Is it the anti serotonin action, anti histamine, or both together? Or something else?

@DaveFoster could you explain, in detail?

Mostly the anti-histamine effect increasing appetite and causing drowsiness.

 

[james2388]

Mostly the anti-histamine effect increasing appetite and causing drowsiness.

Second this. Caffeine and antihistamines seem like an interesting combination for this reason. I say caffeine and not necessarily coffee, to reduce any sort of gastritis from an interaction between coffee digestive and the medication.

 

[Estradiol]

5-HT2 antagonism results with a cortisol decrease.

 

[GutFeeling]

The H1 and HT antagonism/inverse agonism probably.

The most frequently
reported side effects of mirtazapine
are transient sedation and weight
gain associated with an increased
appetite, due to its effects on
5HT2C and histaminergic (H1)
receptors. Also, the drug can be
effective in the treatment of
anorexia nervosa and in cancer
patients with nausea symptoms

Since others H antagonists like buclizine increase appetite alot, i guess that H is the major player

 

[DaveFoster]

What are the main mechanisms for these effects? Is it the anti serotonin action, anti histamine, or both together? Or something else?

@DaveFoster could you explain, in detail?

Majorly, as echoed here, it's the anti-histamine effects in the central nervous system; cyproheptadine strongly blocks the H1 receptor in the brain in the same way as diphenhydramine or other OTC sleep-aids. It's not a hypnotic.

 

[ddjd]

cyproheptadine is a dopamine antagonist (high dopamine can cause insomnia)

but I think the interactions mentioned above have a bigger part to play in its effects