How Did We Evolve To Live Longer?

Mito

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How did we evolve to live longer?

Research shows a collection of small adaptations in stress activated proteins, accumulated over millennia of human history, could help to explain our increased natural defences and longer lifespan.”

“In the study the authors were able to identify how a protein called p62 is activated to induce autophagy. They found that p62 can be activated by reactive oxygen species (ROS). ROS are by-products of our metabolism that can cause damage in the cell. This ability of p62 to sense ROS allows the cell to remove the damage and to survive this stress. In lower organisms, such as fruit flies, p62 is not able to do this.

The team identified the part of the human p62 protein which allows it to sense ROS and created genetically modified fruit flies with ‘humanised’ p62. These ‘humanised’ flies survived longer in conditions of stress. Dr Korolchuk adds: “This tells us that abilities like sensing stress and activating protective processes like autophagy may have evolved to allow better stress resistance and a longer lifespan.”


Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

We propose that the redox-sensitivity of p62 may have evolved in vertebrates as a mechanism that allows activation of autophagy in response to oxidative stress to maintain cellular homoeostasis and increase cell survival.”
 

Tenacity

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I guess Americans have undergone genetic mutations in the past two years...
 
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I’m not sure that we live longer than flies just by virtue of a few mutated proteins...
 

x-ray peat

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How did we evolve to live longer?
We propose that the redox-sensitivity of p62 may have evolved in vertebrates as a mechanism that allows activation of autophagy in response to oxidative stress to maintain cellular homoeostasis and increase cell survival.”
How to Increase Autophagy for Lifespan Extension - Rogue Health and Fitness
good article on how increasing autophagy can increase lifespan which is what the op's paper is pointing to. Has anyone looked into autophagy? IIRC Ray thinks that calorie restriction works because of methionine restriction or toxin reduction but it seems that all the longevity protocols involve increasing autophagy.

Essential role for autophagy in life span extension. - PubMed - NCBI
https://www.sciencedaily.com/releases/2017/07/170705133005.htm
Can autophagy promote longevity?
 
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Are you sure? Is there any evidence for this?

Bible-KJV-King-James-Version.jpg


That would have little to do with evolution though.

You're right. It's more like devolution
 
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That would be a matter of perspective, unlike the bare claim of shortened average lifespan. Should it be true, it would be an issue of lifestyle, not biological inheritance.

Lol if you think modern humans compare to the great men of yesteryear.

Hell we barely compare to the average man of 50 years ago.

Go back and watch idiocracy but replace IQ with every positive human trait.
 

Prosper

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Lol if you think modern humans compare to the great men of yesteryear.

Hell we barely compare to the average man of 50 years ago.

Go back and watch idiocracy but replace IQ with every positive human trait.
You misinterpret me. I am not saying you are wrong. I am saying you are right for wrong reasons. Which is perhaps even worse.
 

Herbie

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An Australian archaeologist may have debunked the myth that people in the Middle Ages did not live much past 40, by studying their teeth.

Her research suggests many more people lived to a ripe old age in medieval times than previously thought. She determined several were older than 75 when they died.

"For people living traditional lives, without modern medicine or markets, the most common age of death is about 70."

More people lived to ripe old age in Middle Ages than previously thought: archaeologist
 

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