1. Spring Sale 10% Off @ LifeGivingStore.com Till June 10th With Coupon Code: SPRING2020
    Click Here!
    Dismiss Notice
  2. LifeGivingStore.com New Products List:
    Natural Dessicated Thyroid

    Magnesium Hydroxide

    Dismiss Notice

Hot Flashes, Night Sweats, The Relationship To Stress, KMUD Herb Doctors , 2012

Discussion in 'Audio Interview Transcripts' started by burtlancast, Dec 14, 2014.

  1. burtlancast

    burtlancast Member

    Jan 1, 2013
  2. Giraffe

    Giraffe Member

    Jun 20, 2015
    Raymond Peat, Ph.D.

    Hot flashes, Night Sweats, the Relationship to Stress, Aging and Sugar Metabolism

    KMUD, 2012​

    (transcribed by Giraffe, Geneviève Devereaux and verified by Burtlancast)

    HD - Andrew Murray

    HD2 - Sarah Johanesson Murray

    RP - Ray Peat

    SE – Sound engineer

    HD: Good evening.Tonight’s subject is:hot flashes, night sweats and their relationship to stress, ageing and sugar metabolism. Dr Peat, for those who‘ve never heard of you before, could you please quickly introduce yourself ?

    RP: Between 1968 and 72, I studied biology at the University of Oregon, specializing in physiology, especially reproductive ageing and the related biochemistry.

    HD: The subject that I was gonna ask you this evening, especially for our female listeners, is the subject of hot flashes in menopause. Also, the night sweats, unrelated to menopause, but related to the system of body temperature control and the set point, and how that can be aberrantly fixed. And sweating can be the subsequent result of that. So, could you describe the set point; it’s not something I’ve really heard of before.

    RP: In mammals, the temperature is regulated by hormones and nerves, partly by causing vasoconstriction or vasodilation in the skin, and sweating. When you want to lower your temperature, you sweat and turn pink, so that your skin radiates, gets blood to the surface where it can, by convection, conduction and radiation release heat into the environment.

    Cold blood animals, like lizards, when they need to increase their temperature, [they] move into the sun, or exercise. Running raises their temperature. For example, to treat an infection, a reptile will sit in the sun and let it’s temperature produce the fever that’s needed to activate the immune system. Humans do that by tightening up the blood vessels in the skin, and reducing sweating. When we're producing a fever, we experience a chill. And in the case of reptiles, they probably feel chilly when they have an infection; and so they have to move into the sunlight, so they feel warm. And they don't feel comfortable until they have a fever.

    When a person is experiencing chills, that means their temperature is rising, because they're producing goose bumps, making the hairs on their skin stand up as the skin gets pale, cutting off circulation. Inside the body, the same adrenaline system is activating energy metabolism, burning sugar faster (or fat in some cases), producing heat faster and losing heat more slowly to raise the temperature.

    The opposite of that, to lower your temperature, you experience a heat surge. People very often confuse the sensation with the actual temperature. So lots of people think they're really getting hotter when they experience a hot flash. But if you measure the core temperature, it typically drops by close to one degree Fahrenheit just in the minutes surrounding a hot flash.

    HD2: Does that mean when a person is experiencing an infection, and their body is alternating chills with sweating, that their body is trying to raise it’s temperature in order to fight the infection, and then it gets too hot, it’s trying to lower it? So they’re actually getting warmer when they feel cold, and colder when they feel hot?

    RP: Yes. The sensation that you experience is closely related to the thermostat’s set point. No one knows exactly how that thermostat works in an animal; but the physical basis for it seems to be the protein, water, fat system in the cell. As the temperature rises, it needs to change its chemistry to maintain a steadiness. To increase the set point, you stabilize this cytoplasmic system, so that it becomes liquid, basically, at a higher temperature. And if you liquefy the structure, it has to decrease the temperature to achieve the normal amount of order. But the details of it just aren't known; but it’s equivalent to a mechanical thermostat.

    HD: How quickly do you think this is possible to achieve, this set point regulation throughout the organism?

    RP: When you administer estrogen to a person, or an animal, their temperature [will decrease] within probably minutes; but usually, it’s measured on an hour scale. It’s a very quick reaction when estrogen gets into the cell, so that they're being excited by it. To offset that excitation, the temperature has to decrease. Apparently, the sensation of being exposed to estrogen is one of warmth; and that very sensation is what lowers our set point.

    HD2: So in menopause, when women are experiencing hot flashes, it’s really down to an increased estrogen and a deficiency of progesterone, which is causing them to feel hot. But their actually body temperature is dropping. So their set point is at a lower temperature; therefore they sweat more easily, at a lower temperature.

    RP: Um, yah. All the symptoms of menopause (including the hot sweats) set in when progesterone fails to be produced. But the estrogen levels (even in the serum) are pretty much the same in women with and without hot flashes. It’s the absence of the anti-estrogens (progesterone and androgens) that cause the symptoms of hot flashes.

    HD2: Why are we told by the medical community that it's really a deficiency of estrogen, and you need to take estrogen to replace this deficient hormone, when in fact it's a deficiency in progesterone?

    RP: There are more and more people realizing that. Just in the last few months, two different people have published on that subject. But the evidence, really, is clearly on the side of the progesterone deficiency. It started back in the 30’s, when the drug companies wanted to sell, at first, a synthetic estrogen product (DES:Diethylstilbestrol). Then they did have a [semi-]synthetic estradiol (ethynyl estradiol), that became one of the staples. This ethynyl estradiol was, I think they say, 17 times more powerful than natural estrogen. To sell those products successfully, they had to create an ideology. Progesterone was known to be the main ovarian hormone. Already in the 1930’s, they saw that estrogen was an anti-fertility, abortion-producing hormone, whereas progesterone was the real female hormone that made pregnancy possible. But just to market the product, they created this whole ideology, calling estrogen “the female hormone”, and saying that “the ovaries fail: they simply run out of eggs at a certain age; and when they run out of eggs, they don't produce estrogen; and the failure of estrogen is the loss of femaleness.” And so, they said, "If you replace estrogen, you could maintain pregnancy, prevent miscarriage and prevent the loss of femininity with ageing." All of that was just an advertising; but lots of doctors fell for it.

    HD2: And lots of poor women suffered with deformed babies?

    RP: Millions, yah.

    HD: You mentioned in your newsletter that DES was first marketed for the prevention of abortions. And then it came out as the “morning after” contraception pill, or the abortion pill.

    RP: Yah, the drug companies got a husband-and-wife team connected with Harvard, and they lobbied the FDA to approve it for treating menopause. And so, they created a legal and public relations environment, based on that completely false idea that estrogen was the fertility hormone.

    HD: It takes such a long time for this sort of thing to come around, when research is coming out all the time. To a point where people finally get it that, actually, it’s completely wrong.

    HD2: Well they stopped those HRT trials (Hormone Replacement Therapy) because women were having strokes and heart attacks. And their bones were not becoming healthier. But now, back again, doctors are prescribing HRT to menopausal women.

    RP: And all of those events, the heart attacks, strokes, dementia, breast cancer and so on, all of that stuff was known on the basis not only of animal studies, going back fifty years, but even in human studies. They saw all of those things in very good studies. It was just that the government did such a big study, that no one could easily deny it. But now, they're running campaigns (these last ten years) to reverse the effects of Women's Health Initiatives study.

    HD2: Pharmaceutical representatives are some of the best paid salesmen/ saleswomen. They are convincing doctors of a very unsafe practice, unfortunately. Because they’re such good sales people.

    HD: The relationship between serotonin and body temperature regulation (or aberration in temperature), and the misconception about serotonin, or 5-HTP, or melatonin being good for you, which is completely bogus... Would you please bring the relationship between the night sweats and estrogen and serotonin?

    RP: Fifty years ago, a similar thing happened with the drug industry and government in relation to serotonin. The disease “carcinoid tumor”, an intestinal tumor that produces serotonin, was being studied just when serotonin was discovered to be both a brain and an intestinal hormone (but mostly the latter). The drug industry, with [it’s] psychoactive chemicals, wanted for various reasons (which my newsletters talked about) to create this idea that serotonin was the “hormone of bliss” (they called it). It was something to be raised to create well-being. But still, the carcinoid study was identifying it as a stress-related hormone that caused flushing.

    One of the basic signs of having that intestinal disease was frequent flushing, as well as psychiatric symptoms. One of the effects of serotonin is to activate the stress hormones, (the cortisol system) and to activate aromatase (the enzyme that makes estrogen). But estrogen also releases and activates the production of serotonin. And so, it can become a vicious circle: one of stress, flushing, tissue break down under the influence of cortisol, and so on.

    HD2: Cortisol is a back-up mechanism for survival when normal healthy metabolism fails to work. Cortisol is the stress hormone that keeps you alive but under an unhealthy metabolism.

    RP: Yah, that's where the sugar metabolism comes in. Estrogen's basic effect is to shift metabolism away from sugar to burning fat (as a basic defense mechanism). If you're starving, you don't want to eat up your body tissues converting protein to glucose. And so, under stress, you have to turn your metabolism towards oxidizing fats. But at the same time you turn off your thyroid, which is responsible for oxidizing sugar efficiently. (PS: starvation turns on flushing)

    HD2: So, this keeps you alive through times of famine?

    RP: Yes; it slows your metabolism down and makes you burn fat and spare your tissues by not turning protein to sugar.

    HD2: So, some listeners must think, "Oh great! It makes me burn fat. That must be a good thing." .

    RP: Except that it slows your metabolism so much.

    HD2: As a consequence, that little bit of fat burning doesn't account for much weight loss at all.

    RP: Very little.

    HD2: It probably accounts for weight gain.

    RP: And in most species, that kind of metabolism puts the animal into torpor, or into hibernation. And when an animal is getting ready to hibernate, it tends to stock up its tissues with lots of polyunsaturated fats. They found that they could bring on torpor or hibernation by either feeding them, or injecting them with polyunsaturated fats. And if you give them sugar, rather than unsaturated fats, you can keep them from going into torpor.

    HD2: And so, this is a survival mechanism for animals in cold climates; they eat a lot of the polyunsaturated fat rich foods, so they can slow their metabolism, and survive a cold winter, where there isn't much of a food supply. You were telling us about the flamingos in Africa…

    RP: Yah, Leslie Brown, a specialist in flamingos, wrote a book in the 1950’s; and he said that no one really has any idea how long they lived. But he suspected that 130 would be a good estimate. But they've seen that the annual mortality does not change with age. A 50-year-old animal is no more likely to die than a 3-year-old animal.

    HD2: So what's so different in this hot climate in Africa?

    RP: Well, they wade around in hot salty water eating algae that is living at this very, very warm water temperature. And basically, the flamingos live on the blue-green algae. At that high temperature, the algae itself couldn't live if it made polyunsaturated fats (because they would oxidize immediately), so they make saturated fats.

    HD2: And most of the blue-green algaes that are available here are grown in cold climates. And so therefore, their fats are very unsaturated and unstable.

    RP: Yah.

    HD: You mentioned also that that part of Africa has a high CO2 concentration.

    RP: Yah; some of the lakes that the flamingoes wade in, their water feels viscous because of the high sodium carbonate concentration. The carbon dioxide bubbles out of the volcanic rifts and makes the water both salty, alkaline, and very rich in carbon dioxide.

    HD: Would you have any idea of what percentage of CO2 might be present there?

    RP: No, I've heard that the air in some regions has a very high concentration, just seeping out of the volcanic rifts.

    HD: Do you know what makes the flamingos pink?

    RP: Yah, that's some kind of algae. (chuckles)

    HD2: So, we know that cold water fish are forced to have an unsaturated fat in order for it to remain liquid under their cold temperatures. But you were telling us about fish in the Amazon...

    RP: Yah, they've analyzed the fat in Amazon fish, where probably the average temperature is something like 75, or 80, or maybe 85 degrees, varying with season and rainfall, and so on. But very warm water. And their fat is similar to butter for saturation: about 97%.

    HD: Wow. We have a caller on the air.

    Caller: You were talking about night sweats and estrogen. Now, I have a friend [which means he talks about himself not...]: he’s a male kinda guy. He gets anxiety attacks and he gets night sweats, mostly right in the morning, just before he wakes up. I was wondering how that relates to testosterone, estrogen, or whatever.

    RP: When a man is under severe stress, which can be an infection, or trauma, or starvation, his estrogen multiplies and becomes equivalent to a women's estrogen. And anytime you’re under stress, you’re likely to waste your stored glucose, and have fluctuating episodes of hypoglycemia. And that triggers several things, but especially the release of cortisol, which breaks down your tissues and turns it to sugar. So, when your stress is very high, usually at the end of the night, your cortisol is at its highest for the day. And when you’re stressed by anything metabolic (or by an infection, for example), your cortisol and estrogen can go extremely high. And that brings your blood sugar up; and bringing the blood sugar up lowers the adrenaline system, letting your skin produce sweat and become pink and hot. So that the actual sweating and sense of heat goes with very high cortisol, which normally is the highest around dawn.

    HD2: So, this gentlemen is experiencing a stress during the night due to dropping blood sugar level. So, perhaps if he woke himself up around 2 or 3 and had a glass of orange juice, maybe with a little salt dissolved in it, that might help to lower his stress and keep his blood sugar up?

    RP: Yah, lots of people do that. I've known fat people who had a nightmare every thirty to sixty minutes during the night; and if they would wake themselves up after less time than was enough to cause the nightmare, and had a glass of orange juice or milk, they could lengthen the time between their nightmares in just three or four nights, by catching it in time using an alarm clock. And in just a week or so of preventing those surges of night sweats or nightmares, you could get your liver stocked up with enough glucose that you can sleep usually through the whole night.

    HD: So it's really just a failure of glucose storage. And people not consuming enough sugars. I know we have spoken at lengths about the need for fructose, fruit sugars, specifically. If people consume enough fruit sugars each day, their glycogen stores would be replenished in the liver, and then during the night, when typically we are fasting, there is enough stored sugar to enable the person to get through the night without getting into that anxiety state, using adrenaline as the next worst thing to keep things going.

    HD2: Another thing is when people are under stress, physical or mental they will use up their sugar stores much quicker. A lot of times when people are under stress, they tend not to eat properly; they eat less. And that just creates a viscous cycle of stress hormones raising blood sugar by breaking down fat, and that whole back-up metabolism that can lead to cancer and all sorts of destructive problems.

    RP: It lowers thyroid and progesterone, which are the basic energy producing, protective hormones. And in the absence of those, then you have to increase the acute emergency hormones; serotonin, estrogen and the various inflammatory things. In just the last five or six years there have been several studies showing that menopausal hot flashes can be prevented just with sugar. A big dose of carbohydrate at bedtime will work better than estrogen.

    HD2: And that's just because it's replenishing the liver's stores, so it doesn't have to rely on those stress hormones to get some sugar.

    RP: Yah. And the mechanism by which estrogen does have some effect in reducing hot flashes, it's a very unphysiological effect. When morphine withdrawal is being used as a model of hot flashes, they find that old animals can have such a low metabolism that they don't experience the hot flash. They can simply be already in a hibernating state and don't have the surges to cause the hot flashes. Estrogen lowers the metabolism and apparently can put a person into a state close to hibernation, that they don’t have the surges. Raising their metabolism enough to produce heat cause the flash.

    Another effect is that these high doses of estrogen block the sweating mechanisms. In animal studies, if you look at the actual details, they were stopping the hot flashes, but using a dose of estrogen 2,000 times the physiological amount. In some of the studies of humans showing that estrogen can stop the sweating and flushing, they were using 30 times the physiological amount of estrogen for a young woman, but giving it to menopausal women.

    HD2: And that's why so many women who take HRT tend to put on so much weight, because they are lowering their metabolism so much with all that high dose of estrogen. We do have a couple callers on the line…

    Caller: *** interminable diatribe about professional athlethes using female hormones to mask their corticosteroid use. Alludes to San Francisco Giants’ Melky Cabrera’s “Melky shakes” and to Manny Ramirez. Wants to know if this will shorten their life, or affect their hormonal balance once they quit sports ***

    RP: Progesterone will cover up and protect against many of the toxic steroids. Pregnenolone and progesterone protect against several toxic steroids.

    HD2: But why would athletes take steroids to begin with, if they take progesterone just to mask it?

    RP: I’m not sure what the hormone was they were taking…

    HD2: I think just corticosteroids; cortisone.

    RP: I don't know when an athlete would take the corticoids…

    HD2: Maybe after a game, as an anti-inflammatory. I’m not sure, I'm sorry, my knowledge isn't so great in this area of sport.

    SE: I think they are taking it as performance enhancers.

    HD: Then maybe are they taking the testosterone, or other hormones ? Okay so until we get some clarification, we will take the next caller…

    Caller: What do I tell my doctor when they want to put me on statins for having high cholesterol?

    HD: Tell them not to. Doctor Peat…

    RP: I could send you a lot of research reports on that. But basically, you have to remember they don't just don't inhibit cholesterol, they inhibit a whole system of related chemicals in the body, and impair energy production. They have not only the risk of muscle damage, but also toxic effects on the brain and liver.

    HD2: Tell them you'd like to try a supplement of thyroid first, to get your cholesterol down that way.

    Caller: I like animal fats too.

    HD: Good.

    HD2: Good, saturated animal fats don’t raise cholesterol.

    Caller: I've listened to you guys talk about that for a long time.

    HD2: Avoid pork, chicken and turkey and duck fat.

    Caller: Okay so grass fed beef is probably the best?

    HD2: Yea and lamb. And make sure your thyroid is working. Get your doctor to do a test and take your temperature; and if it’s below 98.6, you could have a thyroid problem. Ask your doctor for a supplement.

    SE: Could you please comment on Bisphenol A, and its use in plastic, and its estrogen mimicking characteristics, and how that might affect the whole estrogen milieu?

    RP: Yah, it’s disastrous early in life (prenatal or infancy exposure). It shapes the whole development of the organism. And an adult is less sensitive to it. But it still is very toxic as a strong estrogen, leading to all of these degenerative and inflammatory effects.

    HD2: So what do you think is the biggest causative factor that has increased Bisphenol A in our lives ?

    RP: Oh, I currently don't know. They have used it in a lot of food packaging things. But now it’s even getting into our water supply.

    HD2: So you mean water bottles, and plastics, and things that food is put in?

    RP: Yah. And even into some municipal water supplies; recycling.

    HD2: Recycling the water?

    RP: No: getting into the ground water and being pumped into water supply systems.

    HD2: And does Bisphenol A cross the placental barrier to the fetus?

    RP: Oh yah.

    HD: Let's get back to what you mentioned about the temperatures for fish. Just mentioning that the fish were consuming microorganisms in the water that was too warm, normally, and that their fat was saturated a lot more that you would normally find in fish. And that this was a beneficial thing for the fish, in terms of not having them to have a polyunsaturated oil in their bodies, because they didn’t need that cold protection.

    RP: There were even studies in salmon, who normally are cold water fish with very highly unsaturated fats. But they fed them diets with less polyunsaturated fats, and found that in some of their endurance tests, they had better performance than the ones on the pure algae [rich in] cold water polyunsaturated fats. So even though they talk about eating cold water fish as being good for people, even fish don’t do so well! (chuckles)

    HD2: Hahaha. And they would do better if they ate blue green algae that was high in saturated fats, because it grew in warm waters.

    RP: Yah. [But] it couldn't be too saturated, because if they went back to the cold ocean, they would harden like a cube of butter.

    HD2: Salmon butter! Maybe you could create a new product, encapsulate it and sell that to people! (chuckles)

    HD: Okay we have another caller on the line.

    Caller: Briefly, I went through a similar experience as the earlier caller who was talking about his physician, wanting to get him on statin drugs. I had that same conversation with my physician and I told her that I would prefer to see if I could figure out some way, any way to avoid taking statin drugs. She said, "Well, there is no rush. Your cholesterol is trending high, your blood pressure is trending high, but you’re not there yet, it’s borderline. So give it a go and get back to me in three months, and we will see how you’re doing."

    I didn’t have a clue what to do, but I knew that I didn’t wanna take statin drugs, so I got into a bunch of diet books, and basically I stayed away from greasy fatty foods, salt, sugar, and got into low bearing exercise. And in three weeks, and not three months, I turned it around: that was 8 years ago. I realize I’m not prescribing for anyone else. I was lucky, I think. But I thought you might have some comments on that. Thank you very much for this program.

    HD: Doctor Peat, I know you won't have too many good things to say about not consuming sugar. I think the biggest change made was not eating greasy foods. America eats too much greasy foods that's all fried in those toxic polyunsaturated fatty acids, wouldn't you agree, Dr Peat?

    RP: Yah. The way it works is that the polyunsaturated fats block your thyroid at all levels of function. In the 1930’s, people knew that removing the thyroid gland [in people]caused an immediate rise in cholesterol. [When] they gave these people a supplement of thyroid, [they observed] an immediate decrease in cholesterol. So, it’s a mirror image. Your thyroid function and metabolic rate going up, your cholesterol goes down. I've seen two people who had cholesterol of 450 or 500mg/dl get bound to normal in just a week by very intense supplementation with fast acting thyroid.

    HD: Okay let’s carry on about the sweats. Let’s go on about night sweats. I've always understood that night sweats was indicative of disease and it wasn't good. What do you think about night sweats and nocturnal temperature regulation ?

    RP: I think it’s the same thing. The body needs to be hot, but the night signal is to cool off the metabolism to permit sleep. And you have to mobilize the nervous system in a different way, shift from sympathetic to parasympathetic. And parasympathetic activation makes you sweat. And getting your blood sugar up is the other thing that shifts you away from the sympathetic dominance. The various things during the night trigger those nervous changes.

    Just lying down tends to shift you towards the parasympathetic dominance, making you sweat more easily. But then, prolonged darkness increases the production of cortisol, which raises your blood sugar and shifts you again away from sympathetic to parasympathetic. So, it's a combination of darkness, the day cycle, - whatever the stress is - , lowering your blood sugar, and then the compensating cortisol raising your blood sugar.

    HD2: So what are some things we can do to fix this?

    RP: One of the things that happens at night is that the shift of the nervous system tends to slow the digestive process. And it can allow bacteria to become more toxin producing during the night. And keeping your intestine clean during the night, as far as possible (eating a carrot in the afternoon, for example, to stimulate the intestine and suppress some of the bacterial growth).

    HD2: A raw grated carrot?

    RP: Yah.

    HD: Okay there is one more caller on the air.

    Caller: Are you saying the beef is the best, kinda of low cholesterol ?

    HD2: Well, yes I was saying to avoid the fats from pigs, chickens, turkeys and ducks: those animals are fed soy and corn, which means they will produce a bad fat. And I was saying if you were gonna eat meat , buy beef and lamb, they have the good saturated fat. It's a myth that it's a bad fat. It’s really the most natural fat. Grass-fed beef meat is of course ideal.

    Caller: Ideal for what reason?

    RP: The grass has a high content of vitamin E. And vitamin E is used primarily in the beef’s [rumens] to destroy the polyunsaturated fats. So, the more vitamin E in the diet, the lower the polyunsaturated fat content of the beef will be.

    Caller: One of the things that I notice when I shop and I look at grass-fed beef, or the commercial beef, is that the grass-fed has a higher fat content.

    RP: It's the ratio of saturated fat to unsaturated that is most important.

    HD2: So a grain-fed cut of beef will have more polyunsaturated oils? Or just less vitamin E?

    RP: Yes, less Vitamin E and more of the unsaturated fats. But it's mostly the low vitamin E that let’s the oil survive the rumen and get into the tissues. So it's the high percentage of polyunsaturated fat that’s the danger, not the quantity of it [on any given moment]. Because if you have lots and lots of perfectly saturated fat, that makes it relatively safe. Like normal beef is 98% saturated and about 2% polyunsaturated.

    Caller: I'm having a little trouble hearing you. I guess the bottom line is which one is better for you, the lower fat commercial one, or the grass-fed one?

    RP: The grass-fed.

    HD2: So, Dr. Peat, I wanna cover some things that we can recommend to people to decrease hot flashes, whether you’re a male or a female.

    RP: Sugar, carbohydrates in general, but especially fruit. Gelatin is the protein that’s best, because it doesn't make any serotonin. Salty foods help to stabilize your blood sugar and lower the stress systems.

    HD2: And there's also some herbs that can help to work on these different systems. Nettle root blocks aromatase enzymes that increase estrogen. Vitex blocks prolactin, which increases estrogen. Aspirin..

    RP: Aspirin and caffeine: aspirin blocks aromatase and caffeine stimulates progesterone production.

    HD: And Lobelia inflata (the Indian tobacco) was one of the other ones: it also has an effect. [HD2: because you were describing the nicotinic receptors having an effect on blocking the sweat.] You mentioned nicotine patches as being FDA approved?

    RP: Well a study is being done right now. I don't know who funded it. It's plausible since it lowers aromatase and lowers estrogen, it might protect against some of the symptoms of hot flashes and such.

    HD2: Lobelia occupies the nicotinic receptors and it's not nicotine, it's lobeline, and it's also effective for helping people stop smoking.

    HD: And that's all we got time for. Thank you….
  3. Giraffe

    Giraffe Member

    Jun 20, 2015
    I have checked the transcript. Changed a couple of things.
  4. OP

    burtlancast Member

    Jan 1, 2013
    Great ! :)
    I've edited the headpost to include your new version.
  5. OP

    burtlancast Member

    Jan 1, 2013
    It's interesting to know that estrogen causes hot flashes at physiological concentrations, but suppresses them at 30 times or more the norm.

    Also, there's a passage i didn't quite get:

    Ray first talks about increasing the set point (of the body temperature), then mentions it needs to be lowered for it to take effect ?
  6. Rafe

    Rafe Member

    Feb 26, 2016
    I like this statement a lot because to me it looks like Peat thinking like an inquisitive layman b/c the chemistry/physics isn't certain. In this I take him to be thinking conceptually and inferring a generality: that at whatever temperature the cytoplasm of the thermostat system loses its structure, it loses heat and it takes more energy to organize potential to regain structure. And, parenthetically, it's better to have that structure loss happen at a higher temperature rather than a lower temp.

    If so, then hot flashes happen more often in someone trying to make energy and support available to allow the set point [maintaining structure at increasing temps] to go up, but the cytoplasmic system for some reason fails to maintain structure. Until one day it doesn't. The stars align.

    With this in mind, I think a lot of people give up too early in trying to interpret Peat's papers. It does take a kind of attention surplus disorder. Me.
  7. PakPik

    PakPik Member

    Feb 24, 2016
    That's exactly how I thought about it. Well said! Better to maintain a little structure with lower temps than to destroy it for the sake of a high temperature reading.
  8. achillea

    achillea Member

    Feb 29, 2016

    I am no luck in downloading this file. I get error 404 Download of the MP3 file: http://uploadingit.com/file/nccm9coejzj ... ritalk.mp3
  9. OP

    burtlancast Member

    Jan 1, 2013
  10. Luann

    Luann Member

    Mar 10, 2016