Higher protein, sugar, and vitamin E consumption beneficial for health/aging

[haidut]

I would say right from the start that there are obviously a very large number of dietary components that can have beneficial effect on our health. The study below cannot possibly look at all of them, but from the ones it examined those three (3) variables the title mentions gave the most benefit when tweaked (in this case increased).

Multidimensional associations between nutrient intake and healthy ageing in humans - BMC Biology
Finally, a Nutrition Study That Recognizes Complexity

"...They used eight models with increasing complexity and interactions between micro and macronutrient intake. The different models not only noted the amount of these nutrients but their relationship to one another, a distinct difference from “univariable” dietary studies. They then correlated the dietary models, what people had eaten, with evidence of dysregulation, or biological aging among the study participants. Here are a few of their key qualitative findings. [1]

Even their most complex model, when considering micro- and macronutrients and other “potential” predictors of health status, “explain less than 5%” of the dysregulation.

• Above-average protein intake coupled with α-tocopherol (Vitamin E) was associated with the lowest levels of dysregulation.
• Above-average carbohydrate intake with average protein and lipid intake was associated with the lowest levels of “biological aging.”

...Their dysregulation score is only one means of measuring biological age; the components of optimum nutrition can vary significantly depending on what you seek to optimize."

 

[Rinse & rePeat]

I believe this study cause I’m living it.

 

[CLASH]

Wait so its not:

-caloric restriction
-protein restriction
-carbohydrate restriction
-fasting
-cold exposure
-resveratrol supplements
-rapamycin
-metformin
-NAD+ infusions

... that extend lifespan?

 

[Rinse & rePeat]

Wait so its not:

-caloric restriction
-protein restriction
-carbohydrate restriction
-fasting
-cold exposure
-resveratrol supplements
-rapamycin
-metformin
-NAD+ infusions

... that extend lifespan?

Don’t forget marathon running!

 

[abady]

i eat tons of carbs and i supplement with vit e daily, going to eat some liver soon yumms!

 

[-Luke-]

Wait so its not:

-caloric restriction
-protein restriction
-carbohydrate restriction
-fasting
-cold exposure
-resveratrol supplements
-rapamycin
-metformin
-NAD+ infusions

... that extend lifespan?

I'm shocked as well.

Next thing they'll tell us there's no real fighting in wrestling or what?

 

[Momma]

Ray Peat’s response as to why he was tweaking his diet as he aged.

I’m supporting the OP; not disagreeing.
Seemed relevant (this was a YouTube comment from TCA ? copied elsewhere).

 

[cs3000]

I would say right from the start that there are obviously a very large number of dietary components that can have beneficial effect on our health. The study below cannot possibly look at all of them, but from the ones it examined those three (3) variables the title mentions gave the most benefit when tweaked (in this case increased).

Even their most complex model, when considering micro- and macronutrients and other “potential” predictors of health status, “explain less than 5%” of the dysregulation.

• Above-average protein intake coupled with α-tocopherol (Vitamin E) was associated with the lowest levels of dysregulation.
• Above-average carbohydrate intake with average protein and lipid intake was associated with the lowest levels of “biological aging.”

...Their dysregulation score is only one means of measuring biological age; the components of optimum nutrition can vary significantly depending on what you seek to optimize."

Seems it concludes diet doesn't have much impact on (their definition of) aging, from what they tested, once already at high age. (but doesn't tell us about before that)
they're concluding (in an already aged population >67 years old) dietary changes account for ~4% of dysregulation on blood tests measuring some nutrients, immune cells, liver/kidney function indicators, and blood oxygen factors, (unless someone falls into extreme ends of diet)

but as you said they can't look at all of them - they're missing a bunch of stuff when they talk about "dysregulation" so this study is lacking big time

i.e theyre not testing heart function, brain function, many other nutrient levels, exercise capacity, etc etc. they did a questionnaire of some of these but what they define as "dysregulation" is more limited

and the test for biological ageing seems not very reliable
"The biological ageing process is no more tractable than nutrition. There is no clear consensus as to what ageing is [25], though most researchers now agree it is multi-factorial [26, 27]. Different methods for quantifying ageing correlate poorly with one another after chronological age adjustment [28], implying that ageing is a compound process. An emerging approach is to measure the effects of ageing via the breakdown in homeostatic regulation (i.e. dysregulation) across physiological systems [10, 29], an approach complementary to ‘biological age’. A statistical distance can be used to quantify how abnormal, or ‘dysregulated’, an individual’s biomarker profile is, either globally or within specific systems. In this way, it is possible to generate dysregulation scores that are predictive of a wide array of health outcomes during ageing, including mortality, frailty, and chronic diseases"



but as far the effect goes low dose vit E helps (but not high dose vitamin E, which can have negative effects
10mg of a-tocopherol. but >20mg+ is associated with harm).
all the vit e supplements are dosed way high

vit E outcome is improved if the population have regular vit C intake (is it the vit c itself, or because that indicates fruit intake with beneficial compounds?)
they found positive correlation to eating trans fats at average intakes (maybe because indicates dairy intake?)

"consuming around 2SD of α-tocopherol above the population mean, while consuming vitamin C and trans-fatty acids at the population mean results in low dysregulation across the four scores, suggesting a systemic benefit of high, but not excessive, α-tocopherol intake"

"We found that consuming α-tocopherol at 2SD above the population average is associated with benefits; in the subject population, this level corresponds to 10.21mg/day of α-tocopherol"
Highlighting the importance of considering non-linearity, more extreme intake patterns (e.g. >4 SDs above average) were associated with harm. This finding accords with the results of RCTs suggesting excessive vitamin E supplementation may increase all-cause mortality

(in model 1 before adjustments) high (> 6000 kJ/day) or low (< 3000 kJ/day) levels of carbohydrates typically had slightly elevated (around 0.25 SD above the population mean) dysregulation scores (Fig. 2A). Very high intakes of lipids (> 4000 kJ/day; note this is within 2SD above the mean lipid intake) had the highest liver/kidney function dysregulation
so the high carb was defined as >350g per day
low carb <175g a day


Analysis of the effects of dietary macronutrients on age-specific mortality in mice has shown that protein restriction when coupled with increased carbohydrate intake, extends median lifespan through reduced mortality in middle life, but that higher protein in late life may reduce mortality [21]. Given that our study population consisted entirely of older adults, our findings with regard to physiological dysregulation are consistent with this experimental literature. Our results are also concordant with numerous studies highlighting the need for increased protein intake in older people, in particular, to offset sarcopenia and decreased physical performance associated with ageing (reviewed in [22, 23]).
It is interesting to speculate, though, whether reapplying our methods to middle-aged cohorts would detect similar benefits of elevated protein intake; the experimental literature, and some data in humans, suggests perhaps not

Accordingly, homeostasis can be maintained across a wide array of nutritional states, with the caveat that when diet becomes too extreme dysregulation can increase very rapidly (‘falling off a dietary cliff’). The tolerance for different diets—the size of the plateau in this analogy—could of course vary as a function of genetic or environmental factors that predispose us to greater risk"

 

[Peatful]

Ray Peat’s response as to why he was tweaking his diet as he aged.

I’m supporting the OP; not disagreeing.
Seemed relevant (this was a YouTube comment from TCA ? copied elsewhere).



View attachment 46025

“However, everything has a context…”




So often overlooked when understanding Ray’s work.

 

[Rinse & rePeat]

Wait so its not:

-caloric restriction
-protein restriction
-carbohydrate restriction
-fasting
-cold exposure
-resveratrol supplements
-rapamycin
-metformin
-NAD+ infusions

... that extend lifespan?

Ha! Ha! Ha! I never heard of rapamycin until your list here and look what one of today’s new posts was about!

Rapamycin is Fantastic

There really has not been much talk of Rapamycin on this forum. When it was brought up in the past, its mTOR inhibition was often talked about as a negative. Many assumed this would lead to muscle wasting and catabolism. Well I am here to tell you, it is worth looking into. Alone it has given...

raypeatforum.com

 

[andrewlee224]

Ray Peat’s response as to why he was tweaking his diet as he aged.

I’m supporting the OP; not disagreeing.
Seemed relevant (this was a YouTube comment from TCA ? copied elsewhere).



View attachment 46025

This makes sense, but after increasing metabolism by skewing towards carbohydrates, it might possibly make sense to increase protein again? Potentially creating low frequency cycles of carbohydrate/protein dominance

 

[Mauritio]

Well, that is interesting. Do you have any idea as to why high doses of vitamin E could be harmful? Maybe because it can cause lower levels of Vitamin K...

 

[CLASH]

Well, that is interesting. Do you have any idea as to why high doses of vitamin E could be harmful? Maybe because it can cause lower levels of Vitamin K...

Excess alpha tocopherol can alter gamma tocopherol metabolism leading to unchecked reactive nitrogen species stress.