High RBC, WBC, Cystatin C, LDH

[X160]

Hello members,
I am 32 years old male, got a health checkup done recently and below are the abnormal values

Lymphocytes absolute count: 3.12 * 10^3/ul (range: 1.0 to 3.0)
LYMPHOCYTE PERCENTAGE : 49.8 % (range 20-40)
TOTAL RBC : 6.11 * 10^6/ul (range: 4.5 to 5.5)
MCV : 77.9 fL (range: 83-101)
MCH: 25.5 pq (range: 27-32)
RDW: 14.7% (range: 11.6-14)
PLATELET TO LARGE CELL RATIO(PLCR) : 17.9% (range: 19.7-42.4)

Netrophils, other blood cells, Hemoglobin, Hematocrit are in range
Homocysteine is in range, HsCRP is 0.3mg/L - in range, PSA is in range. All liver panel are normal. Serum Uric acid, Creatinine, BUN are in range. estimated GFR (based on CKD-EPI) is 110 mL/min/1.73 m2

CYSTATIN C : 1.32 mg/dl (range: <=1.30 mg/dl)
Vitamin D3: 17.59 ng/ml deficiency (range: 30-100 ng/dl)
Iron: 151 ug/dl (range: 65-175)
TOTAL IRON BINDING CAPACITY (TIBC) : 326 ug/dl (range: 225-535)
% TRANSFERRIN SATURATION : 46.32 % (range: 13-45)
FERRITIN : 204.6 ng/ml (range: 22-322)
TESTOSTERONE: 142.42 ng/dl (range: 164.94-753.38)
LACTATE DEHYDROGENASE: 257 u/L (range: 120-246)

Note: I am not living at an elevation and I don't use steroids.

Based on these there are many possibilities and I don't know where to start and hence request help
1. I could be having Hypoxia, driving RBC high which will push LDH high since RBCs use LDH but that cannot explain high Cystatin C which is maintained by Kidneys.
2. High Cystatin C could be coming from high Lymphocyte count which are nucleated cells but not sure why my kidneys are not able to filter it
3. I was down with fever about a month back and recoved with antibiotics so not sure if the Lymphocyte count will stay elevated even after a month
4. High LDH, Cystatin C, high %Transferrin saturation could point to tissue damage and coupled with high RBC, Lymphocyctes could mean Lymphoma
6. Possible kidney damage from high Lymphocyte count which could explain high Cystatin C

Regardless, this is what I am planning to do
1. Get retested after a month but this time with complete blood peripheral smear, Bicarbonate, Ammonia, Ceruloplasmin along with whole abdomen Ultrasound
2. Supplement with Vitamin D3, Methylene blue, Red light daily, Vitamin K2, Vitamin A. I have already been taking Vitamin E, Energin (Vitamin Bs) along with 100 mg doses of Thiamine/Niacinamide spread across the day to stimulate PDH and lower lactate.
3. Drinking Cranberry juice to lower Iron. Ordered IP6 as well. Avoiding foods fortified with Iron
4. Activated Charcoal once or twice a week to deal it from endotoxin angle
5. Antihistamines like Cyproheptadine.



Please help me interpret these results and future course of action.

 

[X160]

@yerrag : this is similar to your situation except that I did not take any enzymes to lyse any plaque that I may have (I am not sure if I have any plaque and my blood pressure is normal)
@haidut

 

[yerrag]

Hi X160 could you post the other markers' values that you deemed normal? Normal reference ranges aren't necessarily optimal.

 

[X160]

Hi X160 could you post the other markers' values that you deemed normal? Normal reference ranges aren't necessarily optimal.

Thank you, @yerrag
HbA1c - 5.3
TOTAL LEUCOCYTES COUNT - 6.27 *10^3 /ul (range - 4.0 to 10.0)
NEUTROPHILS - 43.5% (40-80)
MONOCYTES - 3.8% (0-10)
EOSINOPHILS - 2.4 % (0.0-6.0)
BASOPHILS - 0.2% (<2)
NEUTROPHILS - ABSOLUTE COUNT - 2.73 X 10³ / μL (2.0-7.0)
MONOCYTES - ABSOLUTE COUNT - 0.24 X 10³ / μL (0.2-1)
BASOPHILS - ABSOLUTE COUNT - 0.01 X 10³ / μL (0-0.1)
EOSINOPHILS - ABSOLUTE COUNT - 0.15 X 10³ / μL (0-0.5)
IMMATURE GRANULOCYTES(IG) - 0.02 X 10³ / μL (0-0.3)
NUCLEATED RED BLOOD CELLS - nil
NUCLEATED RED BLOOD CELLS % - nil
HEMOGLOBIN - 15.6 g/dL (13-17)
HEMATOCRIT(PCV) - 47.6 % (40-50)
MEAN CORPUSCULAR VOLUME(MCV) - 77.9 fL (83-101)
MEAN CORPUSCULAR HEMOGLOBIN(MCH) - 25.5 pq (27-32)
MEAN CORP.HEMO.CONC(MCHC) - 32.8 g/dL (31.5-34.5)
RED CELL DISTRIBUTION WIDTH - SD(RDW-SD) - 40.6 fL (39-46)
RED CELL DISTRIBUTION WIDTH (RDW-CV) - 14.7 % (11.6-14)
PLATELET DISTRIBUTION WIDTH(PDW) - 9.9 fL (9.6-15.2)
MEAN PLATELET VOLUME(MPV) - 9.1 fL (6.5-12)
PLATELET COUNT - 286 X 10³ / μL (150-400)
PLATELET TO LARGE CELL RATIO(PLCR) - 17.9 % (19.7-42.4)
PLATELETCRIT(PCT) - 0.26 % (0.19-0.39)

HOMOCYSTEINE- 16.8 μmol/L (<30)
CYSTATIN C - 1.32 mg/L (<= 60 YEARS : <= 1.03 MG/L)
LIPOPROTEIN (A) [LP(A)] - 28 mg/dl (Adults : < 30.0 mg/dl)
25-OH VITAMIN D (TOTAL) - 17.59 ng/ml (DEFICIENCY : <20 ng/ml)
VITAMIN B-12 - 409 pg/ml (Normal : 211 - 911 pg/ml)
APOLIPOPROTEIN - A1 (APO-A1) - 141 mg/dL (Male : 86 - 152)
APOLIPOPROTEIN - B (APO-B) - 118 mg/dL (Male : 56 - 145)
APO B / APO A1 RATIO (APO B/A1) - 0.8 Ratio (Male : 0.40 - 1.26)
FOLATE - 12.9 ng/ml (> 5.38 ng/ml)
HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) : 0.3 mg/L (Adult : <=3.0 mg/L)
INSULIN - FASTING - 5.54 μU/ml (1.9 - 23.0 μU/ML)
AMYLASE - 64.9 U/L (Adults : 28-100 U/L)
LIPASE - 34.3 U/L (Adults : 5.6 - 51.3 U/L)
FRUCTOSAMINE - 275.2 μmol/L (<=286 μmol/L)
BLOOD KETONE (D3HB) - 0.24 mg/dL (0.21-2.81 mg/dL)
PROSTATE SPECIFIC ANTIGEN (PSA) - 1.1 ng/ml (Normal : Less than 4.00 ng/ml)
SERUM COPPER - 100.5 μg/dL (MALE : 63.5 - 150)
SERUM ZINC - 91.16 μg/dL (52 - 286)

TOTAL CHOLESTEROL : 244 mg/dl (125-200)
HDL CHOLESTEROL - DIRECT : 54 mg/dl (35-80)
LDL CHOLESTEROL - DIRECT : 150 mg/dl (85-130)
TRIGLYCERIDES - 175 mg/dl (25-200)
TC/ HDL CHOLESTEROL RATIO : 4.5 (3 - 5)
LDL / HDL RATIO : 2.8 Ratio (1.5-3.5)
VLDL CHOLESTEROL : 34.96 mg/dl (5 - 40)
NON-HDL CHOLESTEROL : 189.2 mg/dl (< 160)
TOTAL TRIIODOTHYRONINE (T3) : 114 ng/dl (60-200)
TOTAL THYROXINE (T4) : 7.5 μg/dl (4.5-12)
THYROID STIMULATING HORMONE (TSH) : 4.14 μIU/ml (0.3-5.5)
CALCIUM: 9.62 mg/dl (8.8-10.6)
URIC ACID : 5.72 mg/dl (4.2 - 7.3)
BLOOD UREA NITROGEN (BUN) : 11.97 mg/dl (7 - 25)
CREATININE - SERUM : 0.92 mg/dl (0.6-1.1)
BUN / SR.CREATININE RATIO : 13.01 Ratio (9:1-23:1)
SODIUM: 142 mmol/l (136 - 145)
CHLORIDE : 99.3 mmol/l (98 - 107)
EST. GLOMERULAR FILTRATION RATE (eGFR) : 110 mL/min/1.73 m2 (> = 90 : Normal)
FASTING BLOOD SUGAR: 88 mg/dL (70-99)

 

[X160]

I got whole abdomen ultrasound done today and it says :

1. Suspicious left renal non-obstructive calculus measuring 3.3mm in upper pole
2. Right kidney PCS fullness mid/distal ureteric calculus

This is very subjective of the person doing ultrasound but I likely have stone in my left kidney which is giving me slight abdominal pain, I am not sure if this is the cause of high Cystatin C.
Since my serum Vit D3 levels are low, my PTH is probably elevated which could be causing Kidney stones. I am consuming dairy and supplementing Vitamin D3/Vitamin K2