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High Metabolism Quickly Destroys / Chelates Endocrine Disruptors Like BPA

Discussion in 'Scientific Studies' started by haidut, Oct 9, 2018.

  1. haidut

    haidut Member

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    I suspect the topic of endocrine disruptors is on many forum users' minds. We have had multiple discussions about them here, and the ability of chemicals like BPA / BPS to act as thyroid antagonists and estrogen agonists.
    Bpa-free Plastic Just As Dangerous As One With Bpa
    Plasticisers (bpa, Dehp) Boost Pufa, Estrogen, Cortisol & Block Glucose Oxidation
    Chemicals Used In Packaging, Carpets And Utensils (Telfon) Are Endocrine Disruptors
    Chelating BPA

    Now this new study below shows that chemicals like BPA are highly vulnerable to reactive oxygen species (ROS). The authors used a type of "photodynamic therapy" to generate ROS and destroy more than 99% of the BPA in the sample after just 2 hours of exposure. Unfortunately, the mechanism they used would be toxic in people as they used titanium dioxide and UV light as catalysts for ROS generation. Fortunately, there are safer methods that have been shown to work in humans. For example, simply having higher metabolism means generating more ROS. As such, thyroid, progesterone and avoidance of PUFA may be able to achieve the same but likely over longer periods of time. This matches well with Peat's response when asked about endocrine disruptors - i.e. he said simply keeping metabolism high is probably the best protection. However, at some point of tissue saturation with the disruptors, another approach may be needed. Perhaps the safest approach to implement this in humans is with methylene blue (MB) and red light. Either one of these on its own has been shown to increase ROS generation. In the case of MB, this effect starts at tissue concentrations of about 1 uM/L, which for most people can be achieved with doses of 3mg-5mg. Red light has also been shown to increase strongly ROS levels after about 30min of exposure to a bulb of at least 250W power. Combining both has a strongly synergistic effect and has in fact been patented by pharma companies as therapy for a host of diseases from bacterial/viral infections to cancer.
    Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells
    Bacterial Photodynamic Inactivation Mediated by Methylene Blue and Red Light Is Enhanced by Synergistic Effect of Potassium Iodide
    Blue Dye and Red Light, a Dynamic Combination for Prophylaxis and Treatment of Cutaneous Candida albicans Infections in Mice
    Photodynamic Therapy for Cancer
    EP3157337A2 - Induced photodynamic therapy using nanoparticle scintillators as transducers - Google Patents

    Most of the patented formulations use LLLT as the light source in order to ensure easier patent review process since LLLT is by itself considered a medical device in many countries. However, the same beneficial results have been achieved combining MB and any red bulb with sufficient intensity. I think even a 100W red bulb would work but the most pronounced effects is usually seen using 150W bulbs or higher. So, a dose of 5mg MB combined with 30min red light exposure may be all that is needed to do a periodic cleanse of these endocrine disruptors. This concentration (1 uM/L) and red light exposure (several 115 W bulbs for 60min) are widely used in Europe for decontamination of blood plasma from donors, and is known to quickly kill viruses and other pathogens.
    Virus inactivation of blood products by phenothiazine dyes and light. - PubMed - NCBI

    Given that MB builds up in tissues over time, it may be even more effective (and convenient) to take some MB for a week and then do the red light exposure for 30min-60min on just one day of the weekend. Btw, higher doses riboflavin (20mg+ daily) and other quinones like emodin, vitamin K, tetracyclines, etc have a very similar effect and can be used in lieu of MB. If a person spends considerable time outside and there is sufficient sunlight then the red light regimen may not even be needed and simply taking the 5mg MB on a daily basis may be enough.

    https://pubs.acs.org/doi/abs/10.1021/acs.est.8b04301?journalCode=esthag
    New spheres trick, trap and terminate water contaminant

    "...Micron-sized spheres created in the lab of Rice environmental engineer Pedro Alvarez are built to catch and destroy bisphenol A (BPA), a synthetic chemical used to make plastics. The research is detailed in the American Chemical Society journal Environmental Science & Technology. BPA is commonly used to coat the insides of food cans, bottle tops and water supply lines, and was once a component of baby bottles. While BPA that seeps into food and drink is considered safe in low doses, prolonged exposure is suspected of affecting the health of children and contributing to high blood pressure. The good news is that reactive oxygen species (ROS) – in this case, hydroxyl radicals – are bad news for BPA. Inexpensive titanium dioxide releases ROS when triggered by ultraviolet light. But because oxidating molecules fade quickly, BPA has to be close enough to attack."

    "...Cyclodextrin is a benign sugar-based molecule often used in food and drugs. It has a two-faced structure, with a hydrophobic (water-avoiding) cavity and a hydrophilic (water-attracting) outer surface. BPA is also hydrophobic and naturally attracted to the cavity. Once trapped, ROS produced by the spheres degrades BPA into harmless chemicals. In the lab, the researchers determined that 200 milligrams of the spheres per liter of contaminated water degraded 90 percent of BPA in an hour, a process that would take more than twice as long with unenhanced titanium dioxide."
     
  2. Brother John

    Brother John Member

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    Haidut,
    You contribute the greatest articles!
    Thanks Much,
    Brother John
     
  3. Amazoniac

    Amazoniac Member

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  4. Tenacity

    Tenacity Member

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  5. Regina

    Regina Member

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    Fantastic!!
     
  6. Mufasa

    Mufasa Member

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    Would 4 drops of panquinone be enough to radically boost ROS with a lot of natural sunlight exposure?
     
  7. ImprovingDaily

    ImprovingDaily Member

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    Is sunlight still effective for ros if you are pretty well clothed? It's pretty cold as of late where I live and I tend to wear jeans and a sweater in the morning. I assume some of the infrared must penetrate the clothes but I'm not sure.
     
  8. Fractality

    Fractality Member

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    Does it matter how much skin is exposed to the red light?
     
  9. OP
    haidut

    haidut Member

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    Yeah, that should work too.
     
  10. OP
    haidut

    haidut Member

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    I think skin exposure is needed for good penetration in tissues. A light T-shirt also allows a lot of light to get absorbed but thick clothing probably blocks most of it, so red light (or bright any light from incandescent bulb) would be better, especially if only wearing underwear so more skin exposure occurs. The more skin exposure the greater the ROS effect and the shorter the time of exposure needed.
     
  11. Mufasa

    Mufasa Member

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    I think that this strategy of increasing ROS so high may be dangerous if you have a lot of PUFA in your body.
    I think you posted a study that ROS causes lipid peroxidation of cardiolipin if it contains PUFA.
    It would make sense that the body lowers the metabolism if your body contains a lot of PUFA because it can not handle the stress ROS puts on PUFA.

    What do you think @haidut?

    Edit: Here is the study that you posted:
    Edit2 In the past you also warned against too much ROS.
    Edit3 It is probably good when boosting ROS that much to have some niacinamide with it.
     
  12. griesburner

    griesburner Member

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    would this method of raising ROS be dimished when someone takes a lot of antioxidants like chaga tea or something?

    The natural increasing ROS during sun exposure and therefore killing viruses easier would be a better explanation for people getting more easily sick in winrer than the vitamin D theory i guess.
     
  13. Momado965

    Momado965 Member

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    @haidut Will I require 30 minutes of exposure even when using infrared light 830nm or do you think time exposure can be reduced since infrared light is highly penetrative?
     
  14. aguilaroja

    aguilaroja Member

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    Lots of intermediary steps between ROS degradation of BPA in a few hundred milliliters of water and wide application, in water treatment and in living humans. Hope the general point about increased metabolism being super-protective is true.

    If we followed the study guidance, we would be swallowing titanium dioxide, which acts by itself, though less than half as quickly as ROS with UV light added.
    "...200 milligrams of the spheres per liter of contaminated water degraded 90 percent of BPA in an hour, a process that would take more than twice as long with unenhanced titanium dioxide."
    @haidut specifically noted the danger of titanium dioxide
    Common Additive Titanium Dioxide Is Neurotoxic

    It is possible photocatalysis, say with MB and red light, works deeply. However, almost all studies cited used photocatalysis with light applied at close distance to the target.

    Bioremediation of BPA by laccase from oyster mushrooms is arguably farther along, minus dangers of titanium dioxide.
    A highly reusable MANAE-agarose-immobilized Pleurotus ostreatus laccase for degradation of bisphenol A. - PubMed - NCBI

    Edible fungus degrade bisphenol A with no harmful effect on its fatty acid composition. - PubMed - NCBI
     
  15. OP
    haidut

    haidut Member

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    I think red light in the 650nm range is much more penetrative than infrared. The longer the exposure to red light the more ROS would be produced. I don't know if 30min would be enough as in studies 30min is usually the minimum duration of exposure and most studies use 60min or more.
     
  16. Momado965

    Momado965 Member

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    Interesting. Didnt know regular red light is more penetrative than infrared light. How much sub light do you think is necessary daily for ROS production and bpa toxin elimination?
     
  17. Lokzo

    Lokzo Member

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    @haidut,
    You contribute the greatest articles!
    Thanks Much,
    Lucas.
     
  18. Lyall

    Lyall Member

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    Out of interest, hypothetically if one took 5mg of methylene blue and exposed themselves to sunlight would this increase lipofuscin formation?
     
  19. Mufasa

    Mufasa Member

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    I'm wondering the same. ROS seems such a double edged sword.
    It seems that ionizing radiation main toxic effect by raising ROS massively and so causing massive oxidative stress.
    Of course this stress is amplified if you have a lot of iron and PUFA, and your cells are drained of ATP and CO2 and are not in their protective gell like state.

    So MB + light bring this ROS, but different than ionizing radiation, it also brings a lot of ATP and CO2, which is protectful.
    But I would be catious overdoing it, especially if the organism is weak.
    It seems like this is some kind of hormesis that Ray Peat approves of.

    The ROS proabably causes apoptosis and autophagy of cells with damaged mitochrondia.
    It boost metabolism in non damaged but metabolic impaired cells.
    It helps kill cancer cells.
    But when overdoing, the ROS will probably also cause a lot of damage and apoptosis in healthy cells.
    Similar as with ionizing radiation, 500 mg niacinamide + 500 mg inosine may protect from damage from ROS.
     
  20. OP
    haidut

    haidut Member

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    Yes, if there is a lot of PUFA it may cause some issues but if you take vitamin E even once weekly it would greatly mitigate that risk.
    @Lyall
     
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