haidut

Member
Joined
Mar 18, 2013
Messages
17,787
Location
USA / Europe
I suspect the topic of endocrine disruptors is on many forum users' minds. We have had multiple discussions about them here, and the ability of chemicals like BPA / BPS to act as thyroid antagonists and estrogen agonists.
Bpa-free Plastic Just As Dangerous As One With Bpa
Plasticisers (bpa, Dehp) Boost Pufa, Estrogen, Cortisol & Block Glucose Oxidation
Chemicals Used In Packaging, Carpets And Utensils (Telfon) Are Endocrine Disruptors
Chelating BPA

Now this new study below shows that chemicals like BPA are highly vulnerable to reactive oxygen species (ROS). The authors used a type of "photodynamic therapy" to generate ROS and destroy more than 99% of the BPA in the sample after just 2 hours of exposure. Unfortunately, the mechanism they used would be toxic in people as they used titanium dioxide and UV light as catalysts for ROS generation. Fortunately, there are safer methods that have been shown to work in humans. For example, simply having higher metabolism means generating more ROS. As such, thyroid, progesterone and avoidance of PUFA may be able to achieve the same but likely over longer periods of time. This matches well with Peat's response when asked about endocrine disruptors - i.e. he said simply keeping metabolism high is probably the best protection. However, at some point of tissue saturation with the disruptors, another approach may be needed. Perhaps the safest approach to implement this in humans is with methylene blue (MB) and red light. Either one of these on its own has been shown to increase ROS generation. In the case of MB, this effect starts at tissue concentrations of about 1 uM/L, which for most people can be achieved with doses of 3mg-5mg. Red light has also been shown to increase strongly ROS levels after about 30min of exposure to a bulb of at least 250W power. Combining both has a strongly synergistic effect and has in fact been patented by pharma companies as therapy for a host of diseases from bacterial/viral infections to cancer.
Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells
Bacterial Photodynamic Inactivation Mediated by Methylene Blue and Red Light Is Enhanced by Synergistic Effect of Potassium Iodide
Blue Dye and Red Light, a Dynamic Combination for Prophylaxis and Treatment of Cutaneous Candida albicans Infections in Mice
Photodynamic Therapy for Cancer
EP3157337A2 - Induced photodynamic therapy using nanoparticle scintillators as transducers - Google Patents

Most of the patented formulations use LLLT as the light source in order to ensure easier patent review process since LLLT is by itself considered a medical device in many countries. However, the same beneficial results have been achieved combining MB and any red bulb with sufficient intensity. I think even a 100W red bulb would work but the most pronounced effects is usually seen using 150W bulbs or higher. So, a dose of 5mg MB combined with 30min red light exposure may be all that is needed to do a periodic cleanse of these endocrine disruptors. This concentration (1 uM/L) and red light exposure (several 115 W bulbs for 60min) are widely used in Europe for decontamination of blood plasma from donors, and is known to quickly kill viruses and other pathogens.
Virus inactivation of blood products by phenothiazine dyes and light. - PubMed - NCBI

Given that MB builds up in tissues over time, it may be even more effective (and convenient) to take some MB for a week and then do the red light exposure for 30min-60min on just one day of the weekend. Btw, higher doses riboflavin (20mg+ daily) and other quinones like emodin, vitamin K, tetracyclines, etc have a very similar effect and can be used in lieu of MB. If a person spends considerable time outside and there is sufficient sunlight then the red light regimen may not even be needed and simply taking the 5mg MB on a daily basis may be enough.

https://pubs.acs.org/doi/abs/10.1021/acs.est.8b04301?journalCode=esthag
New spheres trick, trap and terminate water contaminant

"...Micron-sized spheres created in the lab of Rice environmental engineer Pedro Alvarez are built to catch and destroy bisphenol A (BPA), a synthetic chemical used to make plastics. The research is detailed in the American Chemical Society journal Environmental Science & Technology. BPA is commonly used to coat the insides of food cans, bottle tops and water supply lines, and was once a component of baby bottles. While BPA that seeps into food and drink is considered safe in low doses, prolonged exposure is suspected of affecting the health of children and contributing to high blood pressure. The good news is that reactive oxygen species (ROS) – in this case, hydroxyl radicals – are bad news for BPA. Inexpensive titanium dioxide releases ROS when triggered by ultraviolet light. But because oxidating molecules fade quickly, BPA has to be close enough to attack."

"...Cyclodextrin is a benign sugar-based molecule often used in food and drugs. It has a two-faced structure, with a hydrophobic (water-avoiding) cavity and a hydrophilic (water-attracting) outer surface. BPA is also hydrophobic and naturally attracted to the cavity. Once trapped, ROS produced by the spheres degrades BPA into harmless chemicals. In the lab, the researchers determined that 200 milligrams of the spheres per liter of contaminated water degraded 90 percent of BPA in an hour, a process that would take more than twice as long with unenhanced titanium dioxide."
 
Last edited:

Brother John

Member
Joined
Feb 10, 2016
Messages
101
I suspect the topic of endocrine disruptors is on many forum users' minds. We have had multiple discussions about them here, and the ability of chemicals like BPA / BPS to act as thyroid antagonists and estrogen agonists.
Bpa-free Plastic Just As Dangerous As One With Bpa
Plasticisers (bpa, Dehp) Boost Pufa, Estrogen, Cortisol & Block Glucose Oxidation
Chemicals Used In Packaging, Carpets And Utensils (Telfon) Are Endocrine Disruptors
Chelating BPA

Now this new study below shows that chemicals like BPA are highly vulnerable to reactive oxygen species (ROS). The authors used a type of "photodynamic therapy" to generate ROS and destroy more than 99% of the BPA in the sample after just 2 hours of exposure. Unfortunately, the mechanism they used would be toxic in people as they used titanium dioxide and UV light as catalysts for ROS generation. Fortunately, there are safer methods that have been shown to work in humans. For example, simply having higher metabolism means generating more ROS. As such, thyroid, progesterone and avoidance of PUFA may be able to achieve the same but likely over longer periods of time. This matches well with Peat's response when asked about endocrine disruptors - i.e. he said simply keeping metabolism high is probably the best protection. However, at some point of tissue saturation with the disruptors, another approach may be needed. Perhaps the safest approach to implement this in humans is with methylene blue (MB) and red light. Either one of these on its own has been shown to increase ROS generation. In the case of MB, this effect starts at tissue concentrations of about 1 uM/L, which for most people can be achieved with doses of 3mg-5mg. Red light has also been shown to increase strongly ROS levels after about 30min of exposure to a bulb of at least 250W power. Combining both has a strongly synergistic effect and has in fact been patented by pharma companies as therapy for a host of diseases from bacterial/viral infections to cancer.
Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells
Bacterial Photodynamic Inactivation Mediated by Methylene Blue and Red Light Is Enhanced by Synergistic Effect of Potassium Iodide
Blue Dye and Red Light, a Dynamic Combination for Prophylaxis and Treatment of Cutaneous Candida albicans Infections in Mice
Photodynamic Therapy for Cancer
EP3157337A2 - Induced photodynamic therapy using nanoparticle scintillators as transducers - Google Patents

Most of the patented formulations use LLLT as the light source in order to ensure easier patent review process since LLLT is by itself considered a medical device in many countries. However, the same beneficial results have been achieved combining MB and any red bulb with sufficient intensity. I think even a 100W red bulb would work but the most pronounced effects is usually seen using 150W bulbs or higher. So, a dose of 5mg MB combined with 30min red light exposure may be all that is needed to do a periodic cleanse of these endocrine disruptors. This concentration (1 uM/L) and red light exposure (several 115 W bulbs for 60min) are widely used in Europe for decontamination of blood plasma from donors, and is known to quickly kill viruses and other pathogens.
Virus inactivation of blood products by phenothiazine dyes and light. - PubMed - NCBI

Given that MB builds up in tissues over time, it may be even more effective (and convenient) to take some MB for a week and then do the red light exposure for 30min-60min on just one day of the weekend. Btw, higher doses riboflavin (20mg+ daily) and other quinones like emodin, vitamin K, tetracyclines, etc have a very similar effect and can be used in lieu of MB. If a person spends considerable time outside and there is sufficient sunlight then the red light regimen may not even be needed and simply taking the 5mg MB on a daily basis may be enough.

https://pubs.acs.org/doi/abs/10.1021/acs.est.8b04301?journalCode=esthag
New spheres trick, trap and terminate water contaminant

"...Micron-sized spheres created in the lab of Rice environmental engineer Pedro Alvarez are built to catch and destroy bisphenol A (BPA), a synthetic chemical used to make plastics. The research is detailed in the American Chemical Society journal Environmental Science & Technology. BPA is commonly used to coat the insides of food cans, bottle tops and water supply lines, and was once a component of baby bottles. While BPA that seeps into food and drink is considered safe in low doses, prolonged exposure is suspected of affecting the health of children and contributing to high blood pressure. The good news is that reactive oxygen species (ROS) – in this case, hydroxyl radicals – are bad news for BPA. Inexpensive titanium dioxide releases ROS when triggered by ultraviolet light. But because oxidating molecules fade quickly, BPA has to be close enough to attack."

"...Cyclodextrin is a benign sugar-based molecule often used in food and drugs. It has a two-faced structure, with a hydrophobic (water-avoiding) cavity and a hydrophilic (water-attracting) outer surface. BPA is also hydrophobic and naturally attracted to the cavity. Once trapped, ROS produced by the spheres degrades BPA into harmless chemicals. In the lab, the researchers determined that 200 milligrams of the spheres per liter of contaminated water degraded 90 percent of BPA in an hour, a process that would take more than twice as long with unenhanced titanium dioxide."
Haidut,
You contribute the greatest articles!
Thanks Much,
Brother John
 

Regina

Member
Joined
Aug 17, 2016
Messages
3,549
Location
Chicago
I suspect the topic of endocrine disruptors is on many forum users' minds. We have had multiple discussions about them here, and the ability of chemicals like BPA / BPS to act as thyroid antagonists and estrogen agonists.
Bpa-free Plastic Just As Dangerous As One With Bpa
Plasticisers (bpa, Dehp) Boost Pufa, Estrogen, Cortisol & Block Glucose Oxidation
Chemicals Used In Packaging, Carpets And Utensils (Telfon) Are Endocrine Disruptors
Chelating BPA

Now this new study below shows that chemicals like BPA are highly vulnerable to reactive oxygen species (ROS). The authors used a type of "photodynamic therapy" to generate ROS and destroy more than 99% of the BPA in the sample after just 2 hours of exposure. Unfortunately, the mechanism they used would be toxic in people as they used titanium dioxide and UV light as catalysts for ROS generation. Fortunately, there are safer methods that have been shown to work in humans. For example, simply having higher metabolism means generating more ROS. As such, thyroid, progesterone and avoidance of PUFA may be able to achieve the same but likely over longer periods of time. This matches well with Peat's response when asked about endocrine disruptors - i.e. he said simply keeping metabolism high is probably the best protection. However, at some point of tissue saturation with the disruptors, another approach may be needed. Perhaps the safest approach to implement this in humans is with methylene blue (MB) and red light. Either one of these on its own has been shown to increase ROS generation. In the case of MB, this effect starts at tissue concentrations of about 1 uM/L, which for most people can be achieved with doses of 3mg-5mg. Red light has also been shown to increase strongly ROS levels after about 30min of exposure to a bulb of at least 250W power. Combining both has a strongly synergistic effect and has in fact been patented by pharma companies as therapy for a host of diseases from bacterial/viral infections to cancer.
Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells
Bacterial Photodynamic Inactivation Mediated by Methylene Blue and Red Light Is Enhanced by Synergistic Effect of Potassium Iodide
Blue Dye and Red Light, a Dynamic Combination for Prophylaxis and Treatment of Cutaneous Candida albicans Infections in Mice
Photodynamic Therapy for Cancer
EP3157337A2 - Induced photodynamic therapy using nanoparticle scintillators as transducers - Google Patents

Most of the patented formulations use LLLT as the light source in order to ensure easier patent review process since LLLT is by itself considered a medical device in many countries. However, the same beneficial results have been achieved combining MB and any red bulb with sufficient intensity. I think even a 100W red bulb would work but the most pronounced effects is usually seen using 150W bulbs or higher. So, a dose of 5mg MB combined with 30min red light exposure may be all that is needed to do a periodic cleanse of these endocrine disruptors. This concentration (1 uM/L) and red light exposure (several 115 W bulbs for 60min) are widely used in Europe for decontamination of blood plasma from donors, and is known to quickly kill viruses and other pathogens.
Virus inactivation of blood products by phenothiazine dyes and light. - PubMed - NCBI

Given that MB builds up in tissues over time, it may be even more effective (and convenient) to take some MB for a week and then do the red light exposure for 30min-60min on just one day of the weekend. Btw, higher doses riboflavin (20mg+ daily) and other quinones like emodin, vitamin K, tetracyclines, etc have a very similar effect and can be used in lieu of MB. If a person spends considerable time outside and there is sufficient sunlight then the red light regimen may not even be needed and simply taking the 5mg MB on a daily basis may be enough.

https://pubs.acs.org/doi/abs/10.1021/acs.est.8b04301?journalCode=esthag
New spheres trick, trap and terminate water contaminant

"...Micron-sized spheres created in the lab of Rice environmental engineer Pedro Alvarez are built to catch and destroy bisphenol A (BPA), a synthetic chemical used to make plastics. The research is detailed in the American Chemical Society journal Environmental Science & Technology. BPA is commonly used to coat the insides of food cans, bottle tops and water supply lines, and was once a component of baby bottles. While BPA that seeps into food and drink is considered safe in low doses, prolonged exposure is suspected of affecting the health of children and contributing to high blood pressure. The good news is that reactive oxygen species (ROS) – in this case, hydroxyl radicals – are bad news for BPA. Inexpensive titanium dioxide releases ROS when triggered by ultraviolet light. But because oxidating molecules fade quickly, BPA has to be close enough to attack."

"...Cyclodextrin is a benign sugar-based molecule often used in food and drugs. It has a two-faced structure, with a hydrophobic (water-avoiding) cavity and a hydrophilic (water-attracting) outer surface. BPA is also hydrophobic and naturally attracted to the cavity. Once trapped, ROS produced by the spheres degrades BPA into harmless chemicals. In the lab, the researchers determined that 200 milligrams of the spheres per liter of contaminated water degraded 90 percent of BPA in an hour, a process that would take more than twice as long with unenhanced titanium dioxide."
Fantastic!!
 

Mufasa

Member
Joined
Jun 10, 2016
Messages
580
Would 4 drops of panquinone be enough to radically boost ROS with a lot of natural sunlight exposure?
 
Joined
Jan 4, 2017
Messages
248
I suspect the topic of endocrine disruptors is on many forum users' minds. We have had multiple discussions about them here, and the ability of chemicals like BPA / BPS to act as thyroid antagonists and estrogen agonists.
Bpa-free Plastic Just As Dangerous As One With Bpa
Plasticisers (bpa, Dehp) Boost Pufa, Estrogen, Cortisol & Block Glucose Oxidation
Chemicals Used In Packaging, Carpets And Utensils (Telfon) Are Endocrine Disruptors
Chelating BPA

Now this new study below shows that chemicals like BPA are highly vulnerable to reactive oxygen species (ROS). The authors used a type of "photodynamic therapy" to generate ROS and destroy more than 99% of the BPA in the sample after just 2 hours of exposure. Unfortunately, the mechanism they used would be toxic in people as they used titanium dioxide and UV light as catalysts for ROS generation. Fortunately, there are safer methods that have been shown to work in humans. For example, simply having higher metabolism means generating more ROS. As such, thyroid, progesterone and avoidance of PUFA may be able to achieve the same but likely over longer periods of time. This matches well with Peat's response when asked about endocrine disruptors - i.e. he said simply keeping metabolism high is probably the best protection. However, at some point of tissue saturation with the disruptors, another approach may be needed. Perhaps the safest approach to implement this in humans is with methylene blue (MB) and red light. Either one of these on its own has been shown to increase ROS generation. In the case of MB, this effect starts at tissue concentrations of about 1 uM/L, which for most people can be achieved with doses of 3mg-5mg. Red light has also been shown to increase strongly ROS levels after about 30min of exposure to a bulb of at least 250W power. Combining both has a strongly synergistic effect and has in fact been patented by pharma companies as therapy for a host of diseases from bacterial/viral infections to cancer.
Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells
Bacterial Photodynamic Inactivation Mediated by Methylene Blue and Red Light Is Enhanced by Synergistic Effect of Potassium Iodide
Blue Dye and Red Light, a Dynamic Combination for Prophylaxis and Treatment of Cutaneous Candida albicans Infections in Mice
Photodynamic Therapy for Cancer
EP3157337A2 - Induced photodynamic therapy using nanoparticle scintillators as transducers - Google Patents

Most of the patented formulations use LLLT as the light source in order to ensure easier patent review process since LLLT is by itself considered a medical device in many countries. However, the same beneficial results have been achieved combining MB and any red bulb with sufficient intensity. I think even a 100W red bulb would work but the most pronounced effects is usually seen using 150W bulbs or higher. So, a dose of 5mg MB combined with 30min red light exposure may be all that is needed to do a periodic cleanse of these endocrine disruptors. This concentration (1 uM/L) and red light exposure (several 115 W bulbs for 60min) are widely used in Europe for decontamination of blood plasma from donors, and is known to quickly kill viruses and other pathogens.
Virus inactivation of blood products by phenothiazine dyes and light. - PubMed - NCBI

Given that MB builds up in tissues over time, it may be even more effective (and convenient) to take some MB for a week and then do the red light exposure for 30min-60min on just one day of the weekend. Btw, higher doses riboflavin (20mg+ daily) and other quinones like emodin, vitamin K, tetracyclines, etc have a very similar effect and can be used in lieu of MB. If a person spends considerable time outside and there is sufficient sunlight then the red light regimen may not even be needed and simply taking the 5mg MB on a daily basis may be enough.

https://pubs.acs.org/doi/abs/10.1021/acs.est.8b04301?journalCode=esthag
New spheres trick, trap and terminate water contaminant

"...Micron-sized spheres created in the lab of Rice environmental engineer Pedro Alvarez are built to catch and destroy bisphenol A (BPA), a synthetic chemical used to make plastics. The research is detailed in the American Chemical Society journal Environmental Science & Technology. BPA is commonly used to coat the insides of food cans, bottle tops and water supply lines, and was once a component of baby bottles. While BPA that seeps into food and drink is considered safe in low doses, prolonged exposure is suspected of affecting the health of children and contributing to high blood pressure. The good news is that reactive oxygen species (ROS) – in this case, hydroxyl radicals – are bad news for BPA. Inexpensive titanium dioxide releases ROS when triggered by ultraviolet light. But because oxidating molecules fade quickly, BPA has to be close enough to attack."

"...Cyclodextrin is a benign sugar-based molecule often used in food and drugs. It has a two-faced structure, with a hydrophobic (water-avoiding) cavity and a hydrophilic (water-attracting) outer surface. BPA is also hydrophobic and naturally attracted to the cavity. Once trapped, ROS produced by the spheres degrades BPA into harmless chemicals. In the lab, the researchers determined that 200 milligrams of the spheres per liter of contaminated water degraded 90 percent of BPA in an hour, a process that would take more than twice as long with unenhanced titanium dioxide."

Is sunlight still effective for ros if you are pretty well clothed? It's pretty cold as of late where I live and I tend to wear jeans and a sweater in the morning. I assume some of the infrared must penetrate the clothes but I'm not sure.
 

haidut

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Thread starter
Joined
Mar 18, 2013
Messages
17,787
Location
USA / Europe
Would 4 drops of panquinone be enough to radically boost ROS with a lot of natural sunlight exposure?

Yeah, that should work too.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,787
Location
USA / Europe
Is sunlight still effective for ros if you are pretty well clothed? It's pretty cold as of late where I live and I tend to wear jeans and a sweater in the morning. I assume some of the infrared must penetrate the clothes but I'm not sure.

I think skin exposure is needed for good penetration in tissues. A light T-shirt also allows a lot of light to get absorbed but thick clothing probably blocks most of it, so red light (or bright any light from incandescent bulb) would be better, especially if only wearing underwear so more skin exposure occurs. The more skin exposure the greater the ROS effect and the shorter the time of exposure needed.
 

Mufasa

Member
Joined
Jun 10, 2016
Messages
580
I suspect the topic of endocrine disruptors is on many forum users' minds. We have had multiple discussions about them here, and the ability of chemicals like BPA / BPS to act as thyroid antagonists and estrogen agonists.
Bpa-free Plastic Just As Dangerous As One With Bpa
Plasticisers (bpa, Dehp) Boost Pufa, Estrogen, Cortisol & Block Glucose Oxidation
Chemicals Used In Packaging, Carpets And Utensils (Telfon) Are Endocrine Disruptors
Chelating BPA

Now this new study below shows that chemicals like BPA are highly vulnerable to reactive oxygen species (ROS). The authors used a type of "photodynamic therapy" to generate ROS and destroy more than 99% of the BPA in the sample after just 2 hours of exposure. Unfortunately, the mechanism they used would be toxic in people as they used titanium dioxide and UV light as catalysts for ROS generation. Fortunately, there are safer methods that have been shown to work in humans. For example, simply having higher metabolism means generating more ROS. As such, thyroid, progesterone and avoidance of PUFA may be able to achieve the same but likely over longer periods of time. This matches well with Peat's response when asked about endocrine disruptors - i.e. he said simply keeping metabolism high is probably the best protection. However, at some point of tissue saturation with the disruptors, another approach may be needed. Perhaps the safest approach to implement this in humans is with methylene blue (MB) and red light. Either one of these on its own has been shown to increase ROS generation. In the case of MB, this effect starts at tissue concentrations of about 1 uM/L, which for most people can be achieved with doses of 3mg-5mg. Red light has also been shown to increase strongly ROS levels after about 30min of exposure to a bulb of at least 250W power. Combining both has a strongly synergistic effect and has in fact been patented by pharma companies as therapy for a host of diseases from bacterial/viral infections to cancer.
Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells
Bacterial Photodynamic Inactivation Mediated by Methylene Blue and Red Light Is Enhanced by Synergistic Effect of Potassium Iodide
Blue Dye and Red Light, a Dynamic Combination for Prophylaxis and Treatment of Cutaneous Candida albicans Infections in Mice
Photodynamic Therapy for Cancer
EP3157337A2 - Induced photodynamic therapy using nanoparticle scintillators as transducers - Google Patents

Most of the patented formulations use LLLT as the light source in order to ensure easier patent review process since LLLT is by itself considered a medical device in many countries. However, the same beneficial results have been achieved combining MB and any red bulb with sufficient intensity. I think even a 100W red bulb would work but the most pronounced effects is usually seen using 150W bulbs or higher. So, a dose of 5mg MB combined with 30min red light exposure may be all that is needed to do a periodic cleanse of these endocrine disruptors. This concentration (1 uM/L) and red light exposure (several 115 W bulbs for 60min) are widely used in Europe for decontamination of blood plasma from donors, and is known to quickly kill viruses and other pathogens.
Virus inactivation of blood products by phenothiazine dyes and light. - PubMed - NCBI

Given that MB builds up in tissues over time, it may be even more effective (and convenient) to take some MB for a week and then do the red light exposure for 30min-60min on just one day of the weekend. Btw, higher doses riboflavin (20mg+ daily) and other quinones like emodin, vitamin K, tetracyclines, etc have a very similar effect and can be used in lieu of MB. If a person spends considerable time outside and there is sufficient sunlight then the red light regimen may not even be needed and simply taking the 5mg MB on a daily basis may be enough.

https://pubs.acs.org/doi/abs/10.1021/acs.est.8b04301?journalCode=esthag
New spheres trick, trap and terminate water contaminant

"...Micron-sized spheres created in the lab of Rice environmental engineer Pedro Alvarez are built to catch and destroy bisphenol A (BPA), a synthetic chemical used to make plastics. The research is detailed in the American Chemical Society journal Environmental Science & Technology. BPA is commonly used to coat the insides of food cans, bottle tops and water supply lines, and was once a component of baby bottles. While BPA that seeps into food and drink is considered safe in low doses, prolonged exposure is suspected of affecting the health of children and contributing to high blood pressure. The good news is that reactive oxygen species (ROS) – in this case, hydroxyl radicals – are bad news for BPA. Inexpensive titanium dioxide releases ROS when triggered by ultraviolet light. But because oxidating molecules fade quickly, BPA has to be close enough to attack."

"...Cyclodextrin is a benign sugar-based molecule often used in food and drugs. It has a two-faced structure, with a hydrophobic (water-avoiding) cavity and a hydrophilic (water-attracting) outer surface. BPA is also hydrophobic and naturally attracted to the cavity. Once trapped, ROS produced by the spheres degrades BPA into harmless chemicals. In the lab, the researchers determined that 200 milligrams of the spheres per liter of contaminated water degraded 90 percent of BPA in an hour, a process that would take more than twice as long with unenhanced titanium dioxide."

I think that this strategy of increasing ROS so high may be dangerous if you have a lot of PUFA in your body.
I think you posted a study that ROS causes lipid peroxidation of cardiolipin if it contains PUFA.
It would make sense that the body lowers the metabolism if your body contains a lot of PUFA because it can not handle the stress ROS puts on PUFA.

What do you think @haidut?

Edit: Here is the study that you posted:
Not sure if this has been posted before, but a few emails from advocates of fish oil promoted my search. I found this study, which was promptly retracted upon publishing due to the author apparently not declaring conflict of interest and misstating his educational credentials. Note that the study was not retracted due to the findings of it being disputed, it's the author they attacked. Given that it is retracted, feel free to take the findings with a grain of salt. However, what is indisputable is that the study cites quite a few other sources which significantly back up its claims.
Overall, a must read for anyone having doubts about PUFA and especially fish oil. The study has references that I had not see so far and they implicate fish oil, and oxidized omega-6 in virtually all degenerative conditions seen today.

Why Fish Oil Fails: A Comprehensive 21st Century Lipids-Based Physiologic Analysis

"...With dietary marine/fish oil supplementation and its EPA/DHA modification of membrane fatty acid composition, which accelerates unnatural lipid peroxidation, significant effects of oxidative damage to many and varied cellular macromolecules occur. For example, peroxidized cardiolipin in the mitochondrial membrane can inactivate cytochrome oxidase by mechanisms similar to those of hydrogen peroxide as well as mechanisms unique to organic hydroperoxides. Dr. Hulbert warns, “Lipid peroxidation should not be perceived solely as ‘damage to lipids,' but should also be considered as a significant endogenous source of damage to other cellular macromolecules, such as proteins and DNA (including mutations)” [18].
Furthermore, the noncharged structure of aldehydes allows their migration with relative ease through hydrophobic membranes and hydrophilic cytosolic media, thereby extending the migration distance far from the production site. On the basis of these features alone, these carbonyl compounds can be more destructive than free radicals and may have far-reaching damaging effects on target sites both within and outside membranes.
Dr. Hulbert makes the importance of mitochondrial functionality clear with his statement, “The insight that the exceptionally long-living species, Homo sapiens, potentially provides for understanding the mechanisms determining animal longevity, is that the fatty acid composition of mitochondrial membranes may be much more important than the composition of other cellular membranes” [17]. A pharmacologic overdose of ALA metabolites exacerbates a shorter lifespan by altering the lipid (mitochondrial) membranes [23].
Mitochondrial cardiolipin molecules are targets of oxygen free radical attack, due to their high content of fatty acids—normally containing negligible long-chain omega-3 metabolites like DHA—unless pharmacologically overdosed as with marine/fish oil. Mitochondrial mediated ROS generation affects the activity of complex I, as well as complexes III and IV, via peroxidation of cardiolipin following oxyradical attack to its fatty acid constituents [18]."

"...Alteration of mitochondrial structure by fish oil was known in 1990 and published at that time in an article in the Proceedings of the National Academy of Science, as follows: “Phospholipase A2 activity and mitochondrial damage are enhanced when mitochondrial membranes are enriched with n-3 fatty acids [from marine/fish oil].

"...Fish oil cannot work, based on human physiology and biochemistry. Humans do not live in frigid waters where an “anti-freeze” is required, that is, EPA/DHA. These so-called active components spontaneously oxidize (radical induced oxidation) at room temperature and are even more problematic at physiologic body temperatures, causing numerous deleterious aldehyde secondary/end products regardless of antioxidant levels. It has been clearly shown that the general population does not suffer impairment of delta-6/-5 desaturation enzyme impairments, as previously thought in the 20th century. Prostate and other cancers along with CVD are predicted to increase in patients consuming fish oil on purely theoretical grounds, utilizing known physiology and biochemistry—and they do—in particular, epithelial cancers and impaired arterial intima."

"...Marine/fish oil, in the supraphysiologic, prophylactic amounts often consumed, is harmful, possibly even more harmful than trans fats [3]. If proper physiologic amounts were utilized (<20 mg EPA/DHA), perhaps their furan acid content would be a significant positive factor; the concern of rampant oxidation is alleviated. Otherwise, given today's high quantities of fish oil recommendation, we see that their furan acid component is rendered ineffective. The medical profession needs to thoroughly review highly quantitative 21st century lipid physiology and biochemistry and offer the appropriate patient warnings. It is sincerely hoped that future researchers will approach the fish oil controversy with a more comprehensive grasp of the lipid biochemistry and physiology involved. Science must take precedence over “studies” which are often open to (mis)interpretation, leading to continual reversals and inconsistent results in clinical trials.
Using the most direct and effective physiologic measure, fish oil in the doses suggested is unequivocally shown to be an anti-antiaging substance, increasing vascular “biologic aging” by over a decade—causing “hardening of the arteries”—compared to PEO consumption. Compared to taking nothing, fish oil decreased subjects' arterial compliance (a bad outcome), by nearly four years [60]. Prophylactic marine oil consumption given its supraphysiologic EPA/DHA amounts—both theoretically and in clinical use—leads to increased inflammation, increased CVD, and increased cancer risk."

Edit2 In the past you also warned against too much ROS.
The effect is similar to the one from methylene blue. Ingesting either one of these and exposing yourself to bright red or sunlight generates too much ROS. Under some conditions (cancer) that is highly desirable but I think for most people it is not something you want to keep doing on a regular basis.
I think any strong oxidizing (i.e. metabolic booster) agent will have a tendency to increase ROS generation. The quinones are decent oxidizing agents but are not the strongest Koch worked with. The triquinoyl is really in a league of its own. Maybe taking some vitamin E with it would help balance the ROS but I have not asked Peat about that.

Edit3 It is probably good when boosting ROS that much to have some niacinamide with it.
Methylene blue (MB) in higher concetrations (5mmol and above) has been show to be cytotoxic and the mechanism is believed to be mainly through increases in lipid peroxidation. This study claims that niacinamide and some other anti-oxidants like vitamin E may mitigate those cytotoxic effects of MB.

Methylene blue plus light-induced lipid peroxidation in rat liver microsomes: inhibition by nicotinamide (vitamin B3) and other antioxidants. - PubMed - NCBI

"...Methylene blue plus visible light, in the presence of oxygen, induced lipid peroxidation in rat liver microsomes, as assessed by the formation of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides and the loss of membrane-bound enzymes. Peroxidation was enhanced by deuteration of the buffer and inhibited by scavengers of singlet oxygen (1O2) and superoxide (O2.-). The damage induced seemed to be mainly due to Type II involving 1O2 and to a lesser extent Type I reactions with O2.- and hydroxyl radical (.OH) as intermediates. Nicotinamide or vitamin B3, an endogenous metabolite occurring at high concentrations in tissues, had a relatively high rate constant of 1.8 x 108 M-1 s-1 with 102 and had a significant inhibitory effect on lipid peroxidation induced by photosensitization. This effect was both time- and concentration-dependent, high inhibition being associated with millimolar concentrations. Chemically related endogenous compounds like tryptophan and isonicotinic acid also had significant inhibitory properties. Similar protective effects were observed with natural antioxidants such as beta-carotene, canthaxanthin, lipoic acid, glutathione, alpha-tocopherol and to a lesser extent ascorbic acid. Nicotinamide was a more effective antioxidant than ascorbic acid. It also showed a similar inhibitory effect against NADPH-ADP-FE3(+)-induced lipid peroxidation. Our results suggest that nicotinamide had significant ability to protect against photosensitization-induced cytotoxicity and cell damage and that it may do so by its ability to react with 102 and other reactive oxygen species."
 
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griesburner

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would this method of raising ROS be dimished when someone takes a lot of antioxidants like chaga tea or something?

The natural increasing ROS during sun exposure and therefore killing viruses easier would be a better explanation for people getting more easily sick in winrer than the vitamin D theory i guess.
 

Momado965

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@haidut Will I require 30 minutes of exposure even when using infrared light 830nm or do you think time exposure can be reduced since infrared light is highly penetrative?
 

aguilaroja

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this new study below shows that chemicals like BPA are highly vulnerable to reactive oxygen species (ROS). The authors used a type of "photodynamic therapy" to generate ROS and destroy more than 99% of the BPA in the sample after just 2 hours of exposure. Unfortunately, the mechanism they used would be toxic in people as they used titanium dioxide and UV light as catalysts for ROS generation. Fortunately, there are safer methods that have been shown to work in humans. For example, simply having higher metabolism means generating more ROS.

Lots of intermediary steps between ROS degradation of BPA in a few hundred milliliters of water and wide application, in water treatment and in living humans. Hope the general point about increased metabolism being super-protective is true.

If we followed the study guidance, we would be swallowing titanium dioxide, which acts by itself, though less than half as quickly as ROS with UV light added.
"...200 milligrams of the spheres per liter of contaminated water degraded 90 percent of BPA in an hour, a process that would take more than twice as long with unenhanced titanium dioxide."
@haidut specifically noted the danger of titanium dioxide
Common Additive Titanium Dioxide Is Neurotoxic

It is possible photocatalysis, say with MB and red light, works deeply. However, almost all studies cited used photocatalysis with light applied at close distance to the target.

Bioremediation of BPA by laccase from oyster mushrooms is arguably farther along, minus dangers of titanium dioxide.
A highly reusable MANAE-agarose-immobilized Pleurotus ostreatus laccase for degradation of bisphenol A. - PubMed - NCBI

Edible fungus degrade bisphenol A with no harmful effect on its fatty acid composition. - PubMed - NCBI
 

haidut

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@haidut Will I require 30 minutes of exposure even when using infrared light 830nm or do you think time exposure can be reduced since infrared light is highly penetrative?

I think red light in the 650nm range is much more penetrative than infrared. The longer the exposure to red light the more ROS would be produced. I don't know if 30min would be enough as in studies 30min is usually the minimum duration of exposure and most studies use 60min or more.
 

Momado965

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I think red light in the 650nm range is much more penetrative than infrared. The longer the exposure to red light the more ROS would be produced. I don't know if 30min would be enough as in studies 30min is usually the minimum duration of exposure and most studies use 60min or more.

Interesting. Didnt know regular red light is more penetrative than infrared light. How much sub light do you think is necessary daily for ROS production and bpa toxin elimination?
 

Lyall

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Out of interest, hypothetically if one took 5mg of methylene blue and exposed themselves to sunlight would this increase lipofuscin formation?
 

Mufasa

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Out of interest, hypothetically if one took 5mg of methylene blue and exposed themselves to sunlight would this increase lipofuscin formation?

I'm wondering the same. ROS seems such a double edged sword.
It seems that ionizing radiation main toxic effect by raising ROS massively and so causing massive oxidative stress.
Of course this stress is amplified if you have a lot of iron and PUFA, and your cells are drained of ATP and CO2 and are not in their protective gell like state.

So MB + light bring this ROS, but different than ionizing radiation, it also brings a lot of ATP and CO2, which is protectful.
But I would be catious overdoing it, especially if the organism is weak.
It seems like this is some kind of hormesis that Ray Peat approves of.

The ROS proabably causes apoptosis and autophagy of cells with damaged mitochrondia.
It boost metabolism in non damaged but metabolic impaired cells.
It helps kill cancer cells.
But when overdoing, the ROS will probably also cause a lot of damage and apoptosis in healthy cells.
Similar as with ionizing radiation, 500 mg niacinamide + 500 mg inosine may protect from damage from ROS.
 

haidut

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I think that this strategy of increasing ROS so high may be dangerous if you have a lot of PUFA in your body.
I think you posted a study that ROS causes lipid peroxidation of cardiolipin if it contains PUFA.
It would make sense that the body lowers the metabolism if your body contains a lot of PUFA because it can not handle the stress ROS puts on PUFA.

What do you think @haidut?

Edit: Here is the study that you posted:


Edit2 In the past you also warned against too much ROS.



Edit3 It is probably good when boosting ROS that much to have some niacinamide with it.

Yes, if there is a lot of PUFA it may cause some issues but if you take vitamin E even once weekly it would greatly mitigate that risk.
@Lyall
 
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