Nick Ireland
Member
- Joined
- Jul 15, 2014
- Messages
- 85
http://scholarworks.wmich.edu/honors_theses/168/
Ray suggests a number of poor health states can increase prostoglandins. It looks like over a certain level they suppress T production directly - in the leydig cells of the testes. We already know from Peat that prostoglandins increase aromotase and therefore lower T (via feedback) while increasing estradiol (E2). They also appear to lower leutenizing (LH) hormone indirectly.
I am wondering if a subset of males with primary hypogonadism are actually overloaded with prostoglandins? If this is the case, then aspirin could be used to turn around this situation, albeit over a few weeks or months, especially as a subset of these patients also have sub clinical hypothyroidism.
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http://aac.asm.org/content/48/1/41.short
Candida albicans is a producer of prostoglandins and increased prostoglandin response. This study shows that Aspirin can completely inhibit candida strains, acting on their bio films.
Personally I have found aspirin to completely abolish my persistent facial flushing whilst on a period of TRT. That may have been prostoglandin inhibition or E2 blockade or both. I did not persist with this experiment but am now trying it again wthout TRT. A short period of vitamin A at doses of 7500iu or above per day produced remarkable results for me - prolactin more than halved and estrogen cut by 40% - blood test confirmed. It did not increase T but I am wondering if aspirin could be the missing link in that equation?
Ray suggests a number of poor health states can increase prostoglandins. It looks like over a certain level they suppress T production directly - in the leydig cells of the testes. We already know from Peat that prostoglandins increase aromotase and therefore lower T (via feedback) while increasing estradiol (E2). They also appear to lower leutenizing (LH) hormone indirectly.
I am wondering if a subset of males with primary hypogonadism are actually overloaded with prostoglandins? If this is the case, then aspirin could be used to turn around this situation, albeit over a few weeks or months, especially as a subset of these patients also have sub clinical hypothyroidism.
-------------------
http://aac.asm.org/content/48/1/41.short
Candida albicans is a producer of prostoglandins and increased prostoglandin response. This study shows that Aspirin can completely inhibit candida strains, acting on their bio films.
Personally I have found aspirin to completely abolish my persistent facial flushing whilst on a period of TRT. That may have been prostoglandin inhibition or E2 blockade or both. I did not persist with this experiment but am now trying it again wthout TRT. A short period of vitamin A at doses of 7500iu or above per day produced remarkable results for me - prolactin more than halved and estrogen cut by 40% - blood test confirmed. It did not increase T but I am wondering if aspirin could be the missing link in that equation?
