1. Spring Sale 10% Off @ LifeGivingStore.com Till June 10th With Coupon Code: SPRING2020
    Click Here!
    Dismiss Notice
  2. LifeGivingStore.com New Products List:
    Natural Dessicated Thyroid

    Magnesium Hydroxide

    Dismiss Notice

High FIGLU And Low Folate Urine, But Blood Folate Ok

Discussion in 'Blood Work, Labs' started by Nick21, Oct 25, 2018.

  1. Nick21

    Nick21 Member

    Joined:
    Apr 11, 2018
    Messages:
    65
    Gender:
    Male
    Hi, I'm confused by recent results I obtained. I took a Genova urine test which indicates excess FIGLU and a folate deficiency. However, a blood test revealed the folate is ok and contradicted the urine result. Is the Genova urine folate result tied to the FIGLU measurement, or do they measure the folate directly. If that is the case, and the folate is fine according to the blood sample which would I suspect is a direct measurement, what does excess FIGLU indicate if reliably measured. Or can someone have a blood folate measure which is fine, and a urine one which is not.
     
  2. Mito

    Mito Member

    Joined:
    Dec 10, 2016
    Messages:
    1,509
    High FIGLU would indicate a probable deficiency of tetrahydrofolate. Blood tests for folate can be either serum or redblood cell (RBC). If you got a serum folate blood test, that measures 5-methyl tetrahydrofolate.
     

    Attached Files:

  3. OP
    Nick21

    Nick21 Member

    Joined:
    Apr 11, 2018
    Messages:
    65
    Gender:
    Male
    Hi Mito, interesting, I will call them Monday and inquire which blood test was performed. On the broader topic, do you think the Genova urine-based folate measurement is tied to their urine FIGLU measurement? Or are they separate measures. Also, in your experience, have the Genova based results been reliable?
     
  4. Mito

    Mito Member

    Joined:
    Dec 10, 2016
    Messages:
    1,509
    According to their guide yes the folate is tied to FIGLU https://www.gdx.net/core/interpretive-guides/ION-IG.pdf

    I don’t have any info on reliability of their testing.
     
  5. OP
    Nick21

    Nick21 Member

    Joined:
    Apr 11, 2018
    Messages:
    65
    Gender:
    Male
    Hi, thanks, but could you point out which page/section specifically indicates that their folate determination stems directly from FIGLU, and is not an independent measure. If the folate value they provide is scaled from FIGLU I could then maybe hypothesize that the blood test showing normal B9 is indeed correct, and not contradicting the urine result, and then the question becomes what else causes excess FIGLU.
     
  6. Mito

    Mito Member

    Joined:
    Dec 10, 2016
    Messages:
    1,509
    Page 4:
    Vitamin B12 and Folic Acid
    The most common dietary deficiency leading to homocysteine elevation and the associated increase in heart disease risk involves vitamin B12 and folic acid. You can have normal blood levels of these vitamins but still not have enough for your body’s enzymes to function properly. Dietary deficiency of vitamin B12 and folic acid are associated with increased
    risk of many diseases, including anemia and the associated chronic fatigue. Methylmalonate is a sensitive functional marker for vitamin B12; high levels of methylmalonate indicate vitamin B12 deficiency (Fig. 1). The odd numbered fatty acids containing 15, 17, 19, or 21 carbon atoms (heptadecanoic acid, nonadecanoic acid, tricosanoic acid, pentadecanoic acid) accumulate in vitamin B12 deficiency. Formiminoglutamate (abbreviated FIGLU) is a compound made from the amino acid histidine (Fig. 2). Insufficiency of folic acid leads to high urinary FIGLU. Folic acid is especially critical for prenatal and childhood development. It is important for lowering your risk of cardiovascular disease and cancer.
    B9ED0A23-FFC7-4187-B512-29CCE08BE017.jpeg
     
  7. OP
    Nick21

    Nick21 Member

    Joined:
    Apr 11, 2018
    Messages:
    65
    Gender:
    Male
    Hi Mito, thanks, but that does not imply that they did not make separate measurements of folate and FIGLU, or whether they determined the folate estimate using FIGLU as a proxy. My attempts to get an answer from the company has not yet been successful.
     
Loading...