Gabriel
Member
- Joined
- May 7, 2013
- Messages
- 229
These studies indicate that overdosing on Vitamin E antagonizes Vitamin K by reducing its tissue levels. The reduction appears to be partly related to the phenomenon thatg Vitamin E and K share similar transporters/metabolizing enzymes. When high dose Vitamin E is given it may block the transporters/enzymes that are needed to integrate Vitamin K into the appropriate tissues.
So similar to Aspirin, one should consider supplementing Vitamin K when trying high dose Vitamin E. Otherwise he may risk Vitamin K deficiency which can cause downstream problems. This effects also appears to affect natural and not only synthetic vitamin E as seen in the study by Booth et al who used natural RRR alpha-tocopherol (fourth reference).
Randomized controlled trials on Vitamin E indicate that this effect may affect overall mortality. In these trials only lower-dose Vitamin E supplementation (<400IE/day) had beneficial effects on mortality, while no beneficial effect and partly deleterious effects were found for high dose Vitamin E supplements (>400IE/day). There are no trials that studied a combination of Vitamin E with Vitamin K.
Some people mentioned side effects when trying high dose Vitamin E. I wonder whether those side effects are also related to its direct Vitamin K antagonizing effect.
_____________________________
Coagulopathy Associated With Vitamin E Ingestion
http://www.ncbi.nlm.nih.gov/pubmed/4479598
Thirteen-week toxicity study of d-alpha-tocopheryl acetate (vitamin E) in Fischer 344 rats.
http://www.ncbi.nlm.nih.gov/pubmed/3804111
Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544331/
Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status.
http://www.ncbi.nlm.nih.gov/pubmed/15213041
Supplementation of rats with a lutein mixture preserved with vitamin E reduces tissue phylloquinone and menaquinone-4.
http://www.ncbi.nlm.nih.gov/pubmed/11276919
Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat.
http://www.ncbi.nlm.nih.gov/pubmed/7867999
Interaction of vitamins E and K: effect of high dietary vitamin E on phylloquinone activity in chicks.
http://www.ncbi.nlm.nih.gov/pubmed/9285253
Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.
http://www.ncbi.nlm.nih.gov/pubmed/22707266
So similar to Aspirin, one should consider supplementing Vitamin K when trying high dose Vitamin E. Otherwise he may risk Vitamin K deficiency which can cause downstream problems. This effects also appears to affect natural and not only synthetic vitamin E as seen in the study by Booth et al who used natural RRR alpha-tocopherol (fourth reference).
Randomized controlled trials on Vitamin E indicate that this effect may affect overall mortality. In these trials only lower-dose Vitamin E supplementation (<400IE/day) had beneficial effects on mortality, while no beneficial effect and partly deleterious effects were found for high dose Vitamin E supplements (>400IE/day). There are no trials that studied a combination of Vitamin E with Vitamin K.
Some people mentioned side effects when trying high dose Vitamin E. I wonder whether those side effects are also related to its direct Vitamin K antagonizing effect.
_____________________________
Coagulopathy Associated With Vitamin E Ingestion
http://www.ncbi.nlm.nih.gov/pubmed/4479598
Thirteen-week toxicity study of d-alpha-tocopheryl acetate (vitamin E) in Fischer 344 rats.
http://www.ncbi.nlm.nih.gov/pubmed/3804111
Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544331/
Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status.
http://www.ncbi.nlm.nih.gov/pubmed/15213041
Supplementation of rats with a lutein mixture preserved with vitamin E reduces tissue phylloquinone and menaquinone-4.
http://www.ncbi.nlm.nih.gov/pubmed/11276919
Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat.
http://www.ncbi.nlm.nih.gov/pubmed/7867999
Interaction of vitamins E and K: effect of high dietary vitamin E on phylloquinone activity in chicks.
http://www.ncbi.nlm.nih.gov/pubmed/9285253
Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.
http://www.ncbi.nlm.nih.gov/pubmed/22707266