High-dose Methylene Blue For Treating Manic-depressive Psychosis

Dan W

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Jan 22, 2013
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A two-year double-blind crossover trial of the prophylactic effect of methylene blue in manic-depressive psychosis. - PubMed - NCBI
A 2-year prophylactic trial was carried out in 31 bipolar manic-depressive subjects, comparing 300 mg/day methylene blue on a double-blind crossover basis with 15 mg/day. All patients were also maintained on lithium. Seventeen patients completed the 2-year trial. During the year the patients were treated with methylene blue at 300 mg/day, they were significantly less depressed than during the year on 15 mg/day. No significant difference in the severity of manic symptoms was shown. The trial had obvious limitations, e.g., a small number of subjects, a relatively large number of dropouts, relatively simple rating scales, doubts about blindness, and uncertainty as to whether or not 15 mg methylene blue per day could be considered a placebo. However, the results suggest that methylene blue may be a useful addition to lithium in the long-term treatment of manic-depressive psychosis and warrants further investigation.

(referenced in this study on methylene blue and depression)
 

AnonSoIDontGetSued

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Jul 8, 2015
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Hello there. Can't open the link you posted and am wondering if there are any brands of methylene available over the counter. Anything in the states you've heard mentioned?

Forum member Haidut has a product that's methylene blue, caffeine, and benzoic acid:
Oxidal - Liquid Dietary Supplement For Oxidation Support

For straight methylene blue there's BlueBrainBoost, although it's officially meant only for research purposes:
BlueBrainBoost - Nootropics and more!

There are also plenty of inexpensive sources intended for labs/terrariums, although those also aren't meant for human consumption. You can find them by googling around, or looking at Nyles7 on ebay.

I haven't researched this part much, but it may be dangerous to combine MB with additional MAOIs.
 

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