High Cortisol In 5-year-old Children Causes Loss Of DNA Methylation In SINE Retrotransposons: A

[Drareg]

Whats interesting here is it's showing cortisol demethylating dna?
Lowering cortisol in certain circumstance might not be ideal?

High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases

"Childhood stress leads to increased risk of many adult diseases, such as major depression and cardiovascular disease. Studies show that adults with experienced childhood stress have specific epigenetic changes, but to understand the pathways that lead to disease, we also need to study the epigenetic link prospectively in children."
Here, we studied a homogenous group of 48 5-year-old children. By combining hair cortisol measurements (a well-documented biomarker for chronic stress), with whole-genome DNA-methylation sequencing, we show that high cortisol associates with a genome-wide decrease in DNA methylation and targets short interspersed nuclear elements (SINEs; a type of retrotransposon) and genes important for calcium transport: phenomena commonly affected in stress-related diseases and in biological aging. More importantly, we identify a zinc-finger transcription factor, ZNF263, whose binding sites where highly overrepresented in regions experiencing methylation loss. This type of zinc-finger protein has previously shown to be involved in the defense against retrotransposon

 

[Dante]

Whats interesting here is it's showing cortisol demethylating dna?
Lowering cortisol in certain circumstance might not be ideal?

High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases

"Childhood stress leads to increased risk of many adult diseases, such as major depression and cardiovascular disease. Studies show that adults with experienced childhood stress have specific epigenetic changes, but to understand the pathways that lead to disease, we also need to study the epigenetic link prospectively in children."
Here, we studied a homogenous group of 48 5-year-old children. By combining hair cortisol measurements (a well-documented biomarker for chronic stress), with whole-genome DNA-methylation sequencing, we show that high cortisol associates with a genome-wide decrease in DNA methylation and targets short interspersed nuclear elements (SINEs; a type of retrotransposon) and genes important for calcium transport: phenomena commonly affected in stress-related diseases and in biological aging. More importantly, we identify a zinc-finger transcription factor, ZNF263, whose binding sites where highly overrepresented in regions experiencing methylation loss. This type of zinc-finger protein has previously shown to be involved in the defense against retrotransposon

Both hyper-methylation plus hypo-methylation are seen in cancers.
DNA methylation - Wikipedia.
In animal models of atherosclerosis, vascular tissue as well as blood cells exhibit global hypomethylation with gene-specific areas of hypermethylation.
From Ray Peat's article -
Protective CO2 and aging - " I suggest that methylation stabilizes and protects cells when growth and regeneration aren't possible (and that it's likely to increase when CO2 isn't available). Hibernation (Morin and Storey, 2009) and sporulation (Ruiz-Herrera, 1994; Clancy, et al., 2002) appear to use methylation protectively. "
Methylation is a complex topic in my view. So, the assumption that since high cortisol causes loss of methylation and hence, it might be good in certain cases can be a hasty one.

 

[thyrulian]

Both hyper-methylation plus hypo-methylation are seen in cancers.
DNA methylation - Wikipedia.
In animal models of atherosclerosis, vascular tissue as well as blood cells exhibit global hypomethylation with gene-specific areas of hypermethylation.
From Ray Peat's article -
Protective CO2 and aging - " I suggest that methylation stabilizes and protects cells when growth and regeneration aren't possible (and that it's likely to increase when CO2 isn't available). Hibernation (Morin and Storey, 2009) and sporulation (Ruiz-Herrera, 1994; Clancy, et al., 2002) appear to use methylation protectively. "
Methylation is a complex topic in my view. So, the assumption that since high cortisol causes loss of methylation and hence, it might be good in certain cases can be a hasty one.

Like with nitric oxide & compensatory vasodilation!

 

[Drareg]

PUFA could be natures hibernating pill for when you need it,it lowers CO2 production.