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I thought you guys might enjoy this one.
"We found that blocking fatty acid oxidation (FAO) in the presence of glucose significantly decreased ATP production in various cancer cells. This suggests that cancer cells depend on fatty acids to produce ATP through FAO instead of glycolysis. We observed that cancer cell growth mainly relies on metabolic nutrients and oxygen systemically supplied through the bloodstream instead of metabolic reprogramming. In a spontaneous mouse tumor model (KrasG12D; Pdx1-cre), tumor growth was 2-fold higher in mice fed a high-fat diet (low-carbo diet) that caused obesity, whereas a calorie-balanced, low-fat diet (high-carbo diet) inhibited tumor growth by 3-fold compared with that in mice fed a control/normal diet. This 5-fold difference in tumor growth between mice fed low-fat and high-fat diets suggests that fat-induced obesity promotes cancer growth, and tumor growth depends on fatty acids as the primary source of energy."
Keep in mind that ketogenic diets in humans don't necessarily cause cancer and that ketones have great anti-cancer benefits. The high-fat rat diet likely accelerated cancer since it's a high PUFA diet.
Things that can enhance glucose oxidation and inhibit fat oxidation are aspirin, B1, niacinamide, pyruvate, meldonium, DCA, etc.
Cancer depends on fatty acids for ATP production: A possible link between cancer and obesity - PubMed
Several metabolic pathways for the supply of adenosine triphosphate (ATP) have been proposed; however, the major source of reducing power for ADP in cancer remains unclear. Although glycolysis is the source of ATP in tumors according to the Warburg effect, ATP levels do not differ between cancer...
pubmed.ncbi.nlm.nih.gov
Keep in mind that ketogenic diets in humans don't necessarily cause cancer and that ketones have great anti-cancer benefits. The high-fat rat diet likely accelerated cancer since it's a high PUFA diet.
Things that can enhance glucose oxidation and inhibit fat oxidation are aspirin, B1, niacinamide, pyruvate, meldonium, DCA, etc.