High Body Fat Percentage Breaks Down DHT To Less Potent Metabolite 3a-diol

[Ron J]

Is there anything else aside from optimal body fat percentage to block/decrease its break down?
This article linked me to the study.

 

[LeeLemonoil]

Good find, highly interesting data. Thanks!

Paragraph on relation between serum and local tissue action of androgens (always interesting to find info on that)

We observed no association between plasma steroid levels and 3α/β-HSD activity measurements with the exception of the 3α-reduced androgen metabolites androsterone-glucuronide and 3α-diol-glucuronide, and with D4-dione, which were positively associated with s.c. 3α/β-HSD activity. Om 3α/β-HSD activity was not related to circulating androgen metabolite levels. These data suggest that steroidogenesis taking place in s.c. adipose tissue may contribute to circulating steroid concentrations due to a mass action effect, whereas Om local steroid conversion may have little or no impact on circulating hormone levels given the relatively small size of this compartment. Quinkler et al.(2004) also suggested that s.c. adipose tissue may contribute significantly to systemic androgen production based on their observation that s.c. adipose tissue predominantly activated androgens, whereas Om adipose tissue predominantly inactivated androgens. However, other studies have shown that local steroid metabolism in adipose tissue may not necessarily reflect circulating steroid levels due to the fact that other tissues, including the liver, also express steroidogenic and/or steroid-inactivating enzymes (Dufort et al. 2001, Rask et al. 2002, Blouin et al. 2005).

 

[Ron J]

Good find, highly interesting data. Thanks!

Paragraph on relation between serum and local tissue action of androgens (always interesting to find info on that)

We observed no association between plasma steroid levels and 3α/β-HSD activity measurements with the exception of the 3α-reduced androgen metabolites androsterone-glucuronide and 3α-diol-glucuronide, and with D4-dione, which were positively associated with s.c. 3α/β-HSD activity. Om 3α/β-HSD activity was not related to circulating androgen metabolite levels. These data suggest that steroidogenesis taking place in s.c. adipose tissue may contribute to circulating steroid concentrations due to a mass action effect, whereas Om local steroid conversion may have little or no impact on circulating hormone levels given the relatively small size of this compartment. Quinkler et al.(2004) also suggested that s.c. adipose tissue may contribute significantly to systemic androgen production based on their observation that s.c. adipose tissue predominantly activated androgens, whereas Om adipose tissue predominantly inactivated androgens. However, other studies have shown that local steroid metabolism in adipose tissue may not necessarily reflect circulating steroid levels due to the fact that other tissues, including the liver, also express steroidogenic and/or steroid-inactivating enzymes (Dufort et al. 2001, Rask et al. 2002, Blouin et al. 2005).

Interesting. Thank you for the information.
What's your opinion about nicotine? In a thread that I read here, someone claimed that it may help keep higher levels of DHT. I think he may have stated to use it weekly.
Also, there seems to be some confusion about boron; some claim that it helps increase DHT, others claim that it raises estrogen/estradiol.